Diversity, Virulence, and Antimicrobial Profiles of Aeromonas spp. in Aquaculture Products: A Decade-Long Study in Eastern China (2012–2022)

Diversity, Virulence, and Antimicrobial Profiles of Aeromonas spp. in Aquaculture Products: A Decade-Long Study in Eastern China (2012–2022)

Wei Gao* | Xiaohua Gao | Wei An

Shanghai Fisheries Research Institute, Shanghai Fisheries Technical Extension Station, Shanghai 200433, China

Corresponding Author Email: 
gaowei10292024@126.com
Page: 
967-978
 |
DOI: 
https://doi.org/10.18280/ijdne.200502
Received: 
15 March 2025
|
Revised: 
17 May 2025
|
Accepted: 
22 May 2025
|
Available online: 
31 May 2025
| Citation

© 2025 The authors. This article is published by IIETA and is licensed under the CC BY 4.0 license (http://creativecommons.org/licenses/by/4.0/).

ijdne_20.05_02.pdf

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Abstract: 

Aeromonas, a foodborne zoonotic pathogen found in aquatic products, causes severe diarrhea in humans. We analyzed antibiotic susceptibility patterns to identify changes in the pathogenicity and resistance of Aeromonas spp. We assessed their prevalence in aquaculture products from 2012 to 2022 and characterized their virulence and antibiotic-resistance genes. Virulence and antibiotic-resistance genes were identified using PCR assays, and whole-genome sequencing was utilized to investigate antimicrobial resistance profiles and virulence factors. Antibiotic susceptibility testing was performed using the microdilution method. We identified eight Aeromonas species (68 strains) in Litopenaeus vannamei and eight fish species. Four types, encompassing 10 known virulence genes, were identified: Type I (exotoxins/enzymes/adhesion factors), Type II (exotoxins/enzymes), Type III (exotoxins/adhesion factors), and Type IV (enzymes). Types I and II were most common. From 2020 to 2022, nearly all strains contained three major classes of virulence genes: exotoxins, enzymes, and adhesion factors. Twelve resistance genes from five major classes were detected. Resistance phenotypes were evaluated using approved aquaculture antibiotics; resistance frequencies to chloramphenicol, sulfamonomethoxine, and sulfamethoxazole/trimethoprim were higher in 2020–2022 than in 2012–2018. This study highlights the evolving pathogenicity and resistance of Aeromonas spp. in aquaculture products over the past decade, emphasizing its importance for food safety.

Keywords: 

Aeromonas spp., antibiotic resistance, aquaculture, virulence genes, whole-genome sequencing

1. Introduction

The global aquaculture industry has experienced rapid growth in response to the increasing demand for high-protein aquatic products, presenting both opportunities and challenges [1]. Aquatic species, including fish and shrimp, are essential for food security [2, 3]. However, this expansion has raised concerns about the overuse of antibiotics and the spread of pathogenic bacteria [4, 5]. Aeromonas spp., a group of opportunistic pathogens, pose significant threats to farmed aquatic species and human health [6-8]. In fish, Aeromonas can cause infections such as septicemia and ulcers, while in humans, infections often arise from ingesting contaminated aquatic products or direct contact with infected aquatic environments, leading to conditions such as gastroenteritis, wound infections, and sepsis [6, 7]. Virulence genes are important indicators of pathogenicity, and the synergistic action of multiple virulence genes can enhance pathogenicity [8, 9].

Although awareness of antimicrobial resistance in agriculture is increasing, the One Health approach—which encompasses the interconnections between human, animal, and environmental health—has predominantly focused on terrestrial livestock, neglecting the substantial impact of aquaculture on antibiotic use and bacterial transmission [4, 5]. Given the extensive scale of aquaculture, this industry serves as a fertile environment for the adaptation and dissemination of bacterial pathogens [10].

In China, the incidence of infections related to Aeromonas has risen, underscoring the critical need for enhanced surveillance in aquaculture [11]. However, current efforts to monitor antibiotic resistance in aquaculture are inadequate, highlighting the need for more focused attention on these emerging risks [12]. A significant challenge in this area is the fragmented nature of available data. Most studies have concentrated on ready-to-eat aquatic products, whereas long-term datasets or those covering a broad spectrum of aquaculture species are notably lacking. Additionally, global data on freshwater aquaculture species are insufficient, particularly in developed countries such as the United States and European nations [13]. Among Asian countries, China notably lacks comprehensive datasets on this issue, despite its significant role in global aquaculture production. In contrast, countries such as Korea and Thailand have made more progress in this area [14, 15]. Shanghai, as a representative city in Eastern China, is characterized by its high population density and significant demand for high-protein aquatic products, making it an ideal location for investigating antimicrobial resistance in aquaculture products. Multilocus sequence typing (MLST) is a crucial tool in bacterial epidemiology, allowing for the tracking of genetic diversity in pathogens such as Aeromonas spp. by analyzing several housekeeping genes [16-18]. This technique facilitates tracing bacterial infections, identifying high-risk antimicrobial resistance genes, and monitoring emerging resistant strains [16, 19]. In this study, MLST was used to explore the distribution, variation, and resistance patterns of Aeromonas strains, thereby enhancing our understanding of their epidemiology.

This study focused on Aeromonas spp. isolated from commonly farmed aquatic species in Shanghai, characterizing their antimicrobial resistance profiles and assessing their public health implications. The findings are expected to inform and enhance monitoring and control strategies for pathogens in aquaculture systems. Ultimately, this study aimed to establish a comprehensive database to manage pathogenic and resistant Aeromonas strains in aquatic products, thereby ensuring the safety and sustainability of these resources.

2. Materials and Methods

2.1 Bacterial strains and culture conditions

A total of 68 Aeromonas strains were isolated from nine aquatic species: mandarin fish (Siniperca chuatsi), yellow catfish (Pelteobagrus fulvidraco), crucian carp (Carassius auratus), grass carp (Ctenopharyngodon idella), silver carp (Hypophthalmichthys molitrix), black carp (Mylopharyngodon piceus), perch (Perca fluviatilis), catfish (Ictalurus punctatus), and shrimp (Litopenaeus vannamei) in Shanghai from 2012 to 2022. These isolates were preserved in 20% glycerol at -80℃ for long-term storage. Working cultures were propagated in Luria-Bertani agar and broth. Details regarding the bacterial isolates used in this study are provided in Table S1. The animal study protocol was approved by the Institutional Review Board of the Shanghai Fisheries Research Institute (protocol code SFRI-202303).

2.2 Antimicrobial susceptibility testing

Antimicrobial susceptibility testing was conducted using the microdilution method, following the standards of the Clinical and Laboratory Standards Institute (CLSI). The susceptibility of the isolated strains to the drugs was assessed, with Escherichia coli ATCC25922 used as the quality control strain. Eight antibacterial agents from five classes were used: sulfamonomethoxine (SMM) and sulfamethoxazole/trimethoprim (SXT) from the sulfonamide class; doxycycline (DOX) from the tetracycline class; enrofloxacin (ENR) from the quinolone class; neomycin sulfate (NEO) from the aminoglycoside class; and florfenicol (FFC) and thiamphenicol (THI) from the chloramphenicol (CHL) class.

For quality control, a drug-free sterile negative control and a drug-free bacterial positive control were established. Each well was inoculated with 100 μL of bacterial suspension diluted to 1 × 106 colony-forming units/mL, followed by incubation at 30℃ for 24 h. Results were then observed, and strains were categorized as resistant (R), intermediate (I), or susceptible (S) based on the minimum inhibitory concentration breakpoints, according to CLSI guidelines.

2.3 Polymerase chain reaction analysis

2.3.1 Species identification

Bacterial genomic DNA extraction and purification were performed using a bacterial genomic DNA kit (Takara Bio Inc., Shiga, Japan), according to the manufacturer’s instructions. PCR amplification was performed using the primers gyrB3F (5′-TCCGGCGGTCTGCACGGCGT-3′) and gyrB14R (5′-TTGTCCGGGTTGTACTCGTC-3′), targeting an approximately 1,100 bp gyrB gene fragment [20]. The PCR reaction mixture included 12.5 µL of PCR mix, 1 µL each of 10 µM gyrB3F and 10 µM gyrB14R, and 50 ng of total DNA template, with a final volume of 25 µL of sterilized double-distilled water. PCR amplification was as follows: initial denaturation at 94℃ for 3 min, 30 cycles at 94℃ for 30 s, annealing at 52℃ for 30 s, and extension at 72℃ for 1 min, followed by a final extension at 72℃ for 5 min. PCR products were visualized using electrophoresis on a 1.5% agarose gel (Sangon Biotech, Shanghai, China) in 1 × TAE buffer.

2.3.2 Determination of virulence genes

To assess potential pathogenicity, PCR analysis of virulence genes, including the Aer (aer), heat-labile enterotoxin (alt), heat-stable enterotoxin (ast), cytotoxic enterotoxin (act), lipase (lip), deoxyribonuclease (exu), glycerophospholipid cholesterol acyltransferase (gcaT), elastase (ahyB), temperature-sensitive protease (eprCAI), and flagellin (fla) genes, was performed according to the methods described by Nawaz et al. [21]. The presence of virulence gene combinations was categorized into four types: Type I (exotoxins + enzymes + adhesion factors), Type II (exotoxins + enzymes), Type III (exotoxins + adhesion factors), and Type IV (enzymes).

2.3.3 Determination of antibiotic-resistance genes (ARGs)

PCR analysis was conducted to determine the presence or absence of 12 ARGs classified into five categories (Table S1). Previously published primer sequences were used for each target ARG. PCR fragments were sequenced by Sangon Biotech (Shanghai, China) and analyzed using the BLAST program (http://www.ncbi.nlm.nih.gov/BLAST).

2.4 Whole-genome sequencing (WGS) and comparative genomic analysis

Genomic DNA was extracted using the Wizard Genomic DNA Purification Kit (Promega, USA) as per the manufacturer’s protocol. Sequencing of qualified DNA was performed by Shanghai Winnerbio Technology Co., Ltd. (Shanghai, China) using the Illumina NovaSeq 6000 platform. To determine the presence of plasmids, the filtered Illumina reads were mapped using SOAP (https://soap.genomics.org.cn/) to the bacterial plasmid database based on GenBank. The rRNA and tRNA genes were identified using Barrnap (version 0.9, https://www.cbs.dtu.dk/services/RNAmmer/) and tRNAscan-SE (version 2.0.8, http://trna.ucsc.edu/software/) with default settings, respectively. Prodigal (version 2.6.3) was used to predict the open reading frame using default parameters. Predicted gene sequences were translated and searched against the National Center for Biotechnology Information (NCBI) non-redundant, UniProt/Swiss-Prot, Pfam, Clusters of Orthologous Groups, and Kyoto Encyclopedia of Genes and Genomes databases for annotation. Additional annotation was conducted using the Virulence Factors of Pathogenic Bacteria and the Comprehensive Antibiotic Resistance Database databases.

2.5 Phylogenetic analysis and average nucleotide identity analysis

Using the existing Aeromonas MLST scheme available at http://pubmlst.org/, six housekeeping genes (gyrB, groL, gltA, metG, ppsA, and recA) were retrieved from the pubMLST database (https://pubmlst.org/organisms/Aeromonas-spp) for MLST analysis. The genomes of Aeromonas strains were then subjected to average nucleotide identity (ANI) analysis to elucidate their phylogenetic relationships. The ANI values were computed using the ANI calculator (Rodriguez, Kostas Lab, Riverside, CA, USA) with default parameters, considering genomes with ANI values ≥ 95% as belonging to the same species, as defined by Colston et al. [16]. A total of 45 reference genomes used for ANI analysis are listed in Table S2. To examine the genetic relatedness among isolates, a phylogenetic tree was constructed using the ParSNP tool (https://github.com/marbl/parsnp) from the Harvest suite [19] based on all identified single-nucleotide polymorphisms in each isolate [22].

2.6 Prediction of virulence factor genes (VFGs) and ARGs

Candidate VFGs and ARGs were analyzed and selected using the Virulence Factors of Pathogenic Bacteria and the Comprehensive Antibiotic Resistance Database databases. All genes were filtered using a 70% similarity threshold. Heatmap visualization was used to present the evolutionary and predicted results of VFGs (Tables S3–S9) and ARGs (Tables S10–S16).

2.7 Data submission to NCBI

The genomic data of Aeromonas strains analyzed in this study were submitted to NCBI under the BioProject accession number PRJNA1219774. Sample data are accessible under SUBID SUB15067125. The NCBI accession numbers and corresponding organisms are provided in Table 1.

Table 1. NCBI accession numbers and corresponding organisms

BioSample

Accession

Organism

SAMN46657247

JBLNHL000000000000

Aeromonas veronii A15

SAMN46657246

JBLNHM000000000000

A. veronii A17

SAMN46657245

JBLNHN000000000000

A. veronii A16

SAMN46657244

JBLNH000000000000

A. hydrophila A12

SAMN46657243

JBLNHP000000000

Aeromonas sp. A04

SAMN46657242

JBLNHQ000000000000

A. veronii A03

SAMN46657241

JBLNHR000000000000

A. hydrophila A01

2.8 Data analysis

MS Excel 2021 (Microsoft, Redmond, WA, USA) was used to analyze the data and generate graphics. These graphics included the classification of VFGs and the number of VFGs carried by isolates in the periods 2012–2014, 2015–2018, and 2020–2022 (Figure 1); the ARGs; the number of ARGs in Aeromonas isolates during 2012–2014, 2015–2018, and 2020–2022 (Figure 2); information on the source, quantity, and name of the isolates (Table 2); prevalence of resistance to different antibiotics (Table 3); and prevalence of intermediate resistance to different antibiotics (Table 4). Data were considered significantly different when P < 0.05.

Figure 1. Classification of virulence genes. Number of VFGs carried by isolates in 2012–2014, 2015–2018, and 2020–2022

A.v = Aeromonas veronii, A.h = A. hydrophila, A.c = A. caviae, A.s = A. sobria, A.sa = A. salmonicida, A.e = A. enteropelogenes, A.j = A. jandaei

Figure 2. Antibiotic-resistance genes (ARGs). Number of ARGs in Aeromonas isolates in 2012–2014, 2015–2018, and 2020–2022

A.v = Aeromonas veronii, A.h = A. hydrophila, A.c = A. caviae, A.s = A. sobria, A.sa = A. salmonicida, A.e = A. enteropelogenes, A.j = A. jandaei

Table 2. Information on the source, quantity, and name of the isolates

Source

Number and Name of Isolates

Aeromonas veronii

A. sobria

A. hydrophila

A. enteropelogenes

A. salmonicida

A. caviae

A. jandaei

A. bestiarum

(n = 32)

(n = 14)

(n = 7)

(n = 6)

(n = 3)

(n = 3)

(n = 2)

(n = 1)

Mandarin fish

0

1

2

0

0

0

0

0

Yellow catfish

1

0

0

0

0

0

0

0

Crucian carp

9

6

2

3

1

2

2

0

Grass carp

2

5

1

1

0

0

0

1

Silver carp

2

0

0

0

0

0

0

0

Black carp

3

0

1

1

1

0

0

0

Perch

3

0

0

0

0

1

0

0

Catfish

1

0

0

0

0

0

0

0

Litopenaeus vannamei

11

2

1

1

1

0

0

0

Table 3. Prevalence of resistance to different antibiotics

Year Range

Strain

Number of Isolates with Antibiotic Resistance (n, %)

Tetracycline

Chloramphenicol

Quinolone

Aminoglycoside

Sulfonamide

DOX

FFC

THI

ENR

NEO

SMM

SXT

2012–2014

Aeromonas veronii (n = 8)

1 (12.5)

 

1 (12.5)

1 (12.5)

 

 

1 (12.5)

A. hydrophila (n = 3)

 

 

 

 

 

 

 

A. caviae (n = 1)

 

 

 

 

 

 

 

2015–2018

A. veronii (n = 5)

2 (40.0)

 

 

 

 

 

 

A. sobria (n = 2)

 

 

 

 

 

1 (50.0)

1 (50.0)

A. salmonicida (n = 1)

 

 

 

 

 

 

 

2020–2022

A. veronii (n = 19)

 

 

2 (10.5)

2 (10.5)

1 (5.3)

1 (5.3)

2 (10.5)

A. hydrophila (n = 4)

 

 

2 (50.0)

 

 

1 (25.0)

2 (50.0)

A. sobria (n = 12)

 

 

 

 

 

1 (8.3)

1 (8.3)

A. enteropelogenes (n = 6)

 

 

2 (33.3)

 

 

 

 

A. salmonicida (n = 2)

 

 

 

 

 

 

 

A. caviae (n = 2)

 

 

1 (50.0)

 

 

1 (50.0)

1 (50.0)

A. jandaei (n = 2)

 

 

 

 

 

1 (50.0)

1 (50.0)

A. bestiarum (n = 1)

 

 

 

 

 

 

 

DOX, doxycycline; FFC, florfenicol; THI, thiamphenicol; ENR, enrofloxacin; NEO, neomycin sulfate; SMM, sulfamonomethoxine; SXT, sulfamethoxazole/trimethoprim.

Table 4. Prevalence of intermediate resistance to different antibiotics

Year Range

Strain

Number of Isolates with Antibiotic Resistance (n, %)

Tetracycline

Chloramphenicol

Quinolone

Aminoglycoside

Sulfonamide

DOX

FFC

THI

ENR

NEO

SMM

SXT

2012–2014

Aeromonas veronii (n = 8)

1 (12.5)

1 (12.5)

 

 

 

 

 

A. hydrophila (n = 3)

1 (33.3)

1 (33.3)

 

 

 

 

 

A. caviae (n = 1)

 

 

 

1 (100)

 

 

 

2015–2018

A. veronii (n = 5)

 

2 (40.0)

 

1 (20.0)

 

 

 

A. sobria (n = 2)

 

 

 

 

 

 

 

A. salmonicida (n = 1)

 

1 (100)

 

 

 

 

 

2020–2022

A. veronii (n = 19)

1 (5.3)

1 (5.3)

 

5 (26.3)

 

 

 

A. hydrophila (n = 4)

1 (25.0)

1 (25.0)

 

 

 

 

 

A. sobria (n = 12)

 

3 (25.0)

 

 

 

 

 

A. enteropelogenes (n = 6)

 

 

 

2 (33.3)

1 (16.7)

 

 

A. salmonicida (n = 2)

 

 

 

1 (50)

 

 

 

A. caviae (n = 2)

 

 

 

 

1 (50)

 

 

A. jandaei (n = 2)

 

 

 

1 (50)

 

 

 

A. bestiarum (n = 1)

 

 

 

 

 

 

 

DOX, doxycycline; FFC, florfenicol; THI, thiamphenicol; ENR, enrofloxacin; NEO, neomycin sulfate; SMM, sulfamonomethoxine; SXT, sulfamethoxazole/trimethoprim

3. Results

3.1 Strains and genotype diversity

From 2012 to 2022, we isolated and purified 68 strains of Aeromonas from aquaculture products originating from nine sources (Table 2). Molecular identification revealed the presence of eight distinct species: A. veronii, A. sobria, A. hydrophila, A. enteropelogenes, A. salmonicida, A. caviae, A. jandaei, and A. bestiarum. To assess temporal changes, the 68 strains were classified into three time periods. From 2012 to 2014, aquaculture products predominantly carried three species: A. veronii, A. hydrophila, and A. caviae. Between 2015 and 2018, the dominant species were A. veronii, A. sobria, and A. salmonicida. Between 2020 and 2022, all eight species mentioned above were present, indicating the highest level of diversity.

Aeromonas exhibited wide distribution across various host species, with L. vannamei primarily hosting five types of bacteria, predominantly A. veronii, whereas fish species primarily hosted eight types of bacteria, dominated by A. veronii, A. sobria, and A. hydrophila.

3.2 Temporal variation in virulence gene distribution

The distribution of virulence genes in the 68 Aeromonas strains across different time intervals revealed dynamic changes in their genetic makeup (Figure 1). Between 2012 and 2014, all ten known VFGs were detected, with aer (11/12, 91.67%), lip (11/12, 91.67%), and exu (12/12, 100%) exhibiting relatively high detection rates. In 2015–2018, the ast gene was not detected. The occurrence of alt (12/12, 100%) was relatively high among the detected genes. Other genes with high detection rates were aer (8/8, 100%), lip (7/8, 87.50%), and exu (8/8, 100%). Similarly, in 2020–2022, nine known virulence genes, not including gcaT, were identified. The detection rates of aer (46/48, 95.83%), lip (44/48, 91.67%), and exu (36/48, 75%) remained high, while that of alt (34/48, 70.83%), which encodes an exotoxin, increased.

The analysis of virulence gene combinations revealed dynamic patterns in Aeromonas strains over the 10-year period. The aer, lip, and exu genes showed consistently high detection rates across all three intervals, indicating their importance in the virulence profile of Aeromonas. Virulence gene combinations were categorized into four types, with Type I combinations being prevalent across seven Aeromonas species: A. veronii, A. hydrophila, A. salmonicida, A. sobria, A. caviae, A. enteropelogenes, and A. jandaei. A. veronii strains consistently carried Types I and II virulence gene combinations across all three intervals, indicating a stable virulence profile over time. Similar trends were observed in A. hydrophila and A. caviae strains in 2012–2014 and 2020–2022. Additionally, A. sobria and A. salmonicida strains exhibited Types I and II combinations in 2015–2018 and 2020–2022. In 2020–2022, A. enteropelogenes carried Types I, II, and III combinations, indicating a broader virulence profile than the other species. A. jandaei predominantly carried Type I combinations, whereas A. bestiarum primarily carried Type II combinations. Overall, Aeromonas strains predominantly carried Types I and II virulence gene combinations throughout the decade, suggesting a stable polymorphism in the carriage of VFGs. Despite fluctuations in the prevalence of specific genes, the overall composition of virulence gene combinations remained consistent over time.

In A. veronii, the types and numbers of virulence and resistance genes showed a consistent trend over the decade, with a decrease observed in 2015–2018, followed by an increase in 2020–2022. In contrast, A. hydrophila strains maintained the same types of virulence genes across intervals but exhibited a significant increase in the carriage of resistance genes in 2020–2022 compared to 2012–2014 (Figures 1 and 2).

3.3 Significant enrichment of ARG types across different periods

Initially, six types of ARGs belonging to four classes of antibiotics were detected from 2012 to 2014, namely tetA, tetB, tetE, CHL (catF), qnrS, and Sul2. This expanded to six types corresponding to five antibiotic classes in 2015–2018 and significantly increased to 14 types covering five antibiotic classes in 2020–2022 (Figure 2).

Across all time intervals, the catF gene consistently showed the highest detection rate among Aeromonas strains, except for A. enteropelogenes, where it was 66.67%. Tetracycline resistance genes (tet) also showed high detection rates across all intervals.

In A. veronii isolates, there was a significant overall increase in the diversity of ARGs over time, with an expansion from four classes and six types of ARGs in 2012–2014 to five classes and 13 genes in 2020–2022. A similar trend was observed in A. hydrophila and A. caviae isolates.

A. sobria and A. salmonicida isolates displayed varying patterns of ARG distribution over time, with an increase in the number of detected genes and classes in 2015–2018 and 2020–2022.

A. bestiarum, A. enteropelogenes, and A. jandaei consistently showed the presence of catF, tet, and qnrS genes in 2020–2022, with a detection rate of 50%–100%. Other ARGs, such as tetA, tetB, strA-strB, and aac(6')-Ib, were also detected in these species to varying extents.

3.4 Temporal variations in antibiotic-resistance profile

Antimicrobial susceptibility tests were conducted on all 68 Aeromonas strains (Table 3). Between 2012 and 2014, only A. veronii showed resistance to four types of antibiotics: DOX, THI, ENR, and SXT, with a resistance rate of 12.5%. Other isolates, such as A. hydrophila and A. caviae, exhibited sensitivity to all tested antibiotics. In 2015–2018, A. veronii showed resistance solely to DOX (33.3%), whereas A. sobria showed resistance to SMM (50%) and SXT (50%). A more diverse pattern of resistance emerged during 2020–2022. Isolates of A. veronii, A. hydrophila, and A. sobria showed varying degrees of resistance to SMM and SXT. Furthermore, A. veronii showed resistance to THI, ENR, and NEO. An escalation in resistance to CHL and sulfonamide drugs was observed among strains during this timeframe. The resistance frequency of all isolates to THI, SMM, and SXT was significantly higher than that observed in 2012–2018. Intermediate resistance, indicative of potentially reduced susceptibility, was also observed across the strains (Table 4). In 2012–2014, A. veronii and A. hydrophila displayed intermediate resistance to DOX and FFC. Similarly, in the subsequent intervals, A. veronii exhibited intermediate resistance to FFC and ENR. A. veronii and A. hydrophila maintained a consistent pattern of intermediate resistance to DOX and FFC throughout 2012–2022. Overall, intermediate resistance across all strains predominantly centered on FFC and ENR.

Figure 3. Heatmap of average nucleotide identity values among the seven isolates and 45 reference genome assemblies

3.5 Genomic characterization and phylogenetic relationships

The genetic characterization of seven sequenced Aeromonas isolates and their phylogenetic relationship with other published isolates (human, AS1) was elucidated through core genome similarity analysis (Figure 3). This revealed that these isolates belonged to three distinct species: A. veronii (A15, A03, A16, A17), A. hydrophila (A01, A12), and a novel species designated as Aeromonas sp. (A04). Genome-wide ANI values were above 95%, indicating close relatedness among the isolates (Table S2).

This species pattern was supported by the maximum likelihood phylogenetic tree, which was constructed based on a gene-by-gene core alignment of genes present in more than 95% of all isolates. The phylogenetic tree revealed the clustering of genomes broadly according to sequence type (ST) (Figure 4). The seven Aeromonas isolates were assigned to six known STs. Specifically, A. hydrophila isolates A01 and A12, obtained from mandarin fish and crucian carp, respectively, clustered together within ST-1826. The four A. veronii isolates formed a distinct cluster, and each was assigned to a different ST: ST-2386 (A15), ST-1113 (A03), ST-903 (A16), and ST-1114 (A17). Three of these isolates originated from L. vannamei, and the remaining isolate was obtained from crucian carp.

Figure 4. Distribution of antibiotic-resistance genes (ARGs) in the seven isolates

Figure 5. Distribution of virulence genes in the seven isolates

Isolate A15 also exhibited a close phylogenetic relationship with an A. veronii reference strain AS1 (NCBI Reference Sequence: NZ_CP114182.1), a clinical isolate from a patient with Crohn’s disease.

3.6 Distribution of VFGs

Analysis of VFGs among the Aeromonas population (n = 7) revealed variations in gene content among different species (Figure 5). The number of VFGs ranged from 118 to 213 over the study period, with A. hydrophila isolates exhibiting more genes (199–213) than Aeromonas sp. isolates (168 genes) and A. veronii isolates (118–132 genes; Tables S3-S9). Aeromonas isolates were categorized into three groups—species classification, ANI, and phylogeny—based on gene presence and absence.

Shared virulence genes among all isolates included those responsible for traits associated with flagella (flgC), lipooligosaccharide synthesis (waaF), and chemotaxis (cheA, cheB, cheR, cheV, cheW, cheY, cheZ). Additionally, unique genes specific to certain strains were identified. For example, the motility accessory factor gene pseB was exclusively detected in A. veronii strains, whereas genes such as ToxA and tviB were found only in the Aeromonas sp. strain (A04).

The proportion of A. veronii and A. hydrophila strains carrying the same virulence genes remained consistently high (> 90%) across different years, indicating stability in the distribution of these genes within these species.

3.7 Distribution of antimicrobial resistance

The presence of horizontally acquired genes encoding resistance to various classes of antibiotics among the seven sequenced Aeromonas isolates was investigated (Tables S10–S16). WGS analysis confirmed the presence of multiple ARGs within the genomes of all seven Aeromonas strains and revealed the presence of different classes of β-lactamases. Among the isolates, A. hydrophila strains A01 and A12 exhibited a shared set of eight unique ARGs, spanning five major classes of antibiotics. These included β-lactamases (blaOXA-724, CepS, and AQU-2), tetracycline (tetE), polymyxin (mcr-7.1), carbapenem (cphA4), cephalosporin (Ceps), and peptide antibiotic (pmrF). In contrast, Aeromonas sp. strain A04 exhibited seven unique ARGs, representing three distinct major classes of antibiotics, namely β-lactamases (blaOXA-427 and FOX-2), polymyxins (arnA and bacA), and carbapenems (cphA4).

In the A. veronii population, 13 unique ARGs were identified, covering five different major classes of antibiotics, namely β-lactamases, tetracycline, diaminopyrimidine, streptogramin, and polypeptide (Figure 4). All four A. veronii isolates carried four horizontally acquired resistance genes, namely CRP, mcr-7.1, MexB, and blaOXA-12, with a gene coverage ranging from 96% to 99%. The presence of tetE was observed in 50% (2/4) of these A. veronii isolates; however, it was absent in the Crohn’s disease isolate AS1. Each of the analyzed bacterial strains contained MexB, a crucial multidrug efflux transporter protein.

4. Discussion

Aeromonas, an emerging foodborne pathogen, poses a significant threat to food safety, particularly in aquatic products, by contributing to contamination and increasing the risk of foodborne illness [23]. The emergence of antibiotic-resistant strains of Aeromonas further heightens these concerns, increases food insecurity, and presents formidable challenges in clinical treatment [6]. Despite these risks, research on pathogenic and antibiotic-resistant strains of Aeromonas in the aquaculture products of Eastern China has been limited. This study fills a critical gap by offering the most comprehensive report on antibiotic-resistant Aeromonas in aquaculture products from Shanghai, a key city in Eastern China. The report provides a decade-long dataset on virulence genes, antimicrobial resistance, and characteristic resistance genes.

In our study, we examined 68 dominant strains of Aeromonas isolated from nine different types of aquaculture products in Shanghai from 2012 to 2022. We systematically selected these strains based on the respective years for species identification, followed by sensitivity testing to eight antibiotics. Our findings align with a previous study by Sadique et al. [24], which showed Aeromonas as the predominant strain, exhibiting diversity within cultured ponds. Our results revealed A. veronii as the most prevalent strain, followed by A. hydrophila. Additionally, we identified other species, such as A. sobria, A. salmonicida, A. jandaei, A. enteropelogenes, A. caviae, and A. sp. These observations are consistent with those of previous studies. For example, a study conducted on farmed Nile tilapia (Oreochromis niloticus) in the Philippines also highlighted A. veronii as the dominant strain, followed by A. jandaei and A. caviae [25]. Similarly, research on Aeromonas diversity in Thailand, using sequencing and phylogenetic analysis of the gyrB gene, confirmed the presence of six Aeromonas species, with A. veronii comprising the majority (72.1%), followed by A. jandaei (11.6%) [14]. These findings demonstrate the global importance of Aeromonas as a pathogen in aquatic products.

Aeromonas spp., including A. veronii, A. caviae, and A. hydrophila, are widely recognized pathogens linked to infectious diarrhea [26-29], with a study by the Chinese CDC highlighting the presence of a consistent strain species among adult patients with diarrhea in Beijing [11]. The pathogenesis of Aeromonas-induced diarrhea is complex, with no single virulence factor definitively identified as the sole cause [30]. It is generally believed that the carriage of multiple virulence genes contributes to the pathogenicity of these bacteria [8, 9]. For instance, Aslani et al. [31] reported that various genotypes carrying virulence genes, such as aerA, hlyA, alt, ast, and act, are associated with diarrheal illnesses. In Malaysia, 50% of isolates from cultured freshwater fish carry virulence genes, including aer, alt, hly, lip, fla, and act [32]. Similarly, in Southeast China, Aeromonas strains causing bacteremia exhibit a high prevalence of virulence genes such as aer, lip, hlyA, alt, ast, and act [33]. Albert et al. [34] found that 56% of diarrheal isolates from children in Bangladesh contain the alt and ast genes.

From 2012 to 2022, the genes aer, lip, and exu were consistently detected at high rates. A prevalent combination of Type I virulence genes was observed in seven Aeromonas species; these genes encode exotoxins (such as alt, act, ast, and aer), enzymes (including exu, lip, gcaT, eprCAI, and ahyB), and adhesion factors (such as fla). In comparison to the findings of other research, the virulence genes we found in Aeromonas strains show regional differences and polymorphisms, indicating genetic diversity [14, 24]. However, these genes remained stable over the studied decade, suggesting a consistent genetic profile of Aeromonas in Shanghai's aquaculture environment. The similarity between the virulence patterns of the strains in our study and those from strains isolated from clinical settings underscores the pathogenic potential of these bacteria. Therefore, heightened awareness is crucial for identifying Aeromonas as a possible foodborne pathogen that poses a risk to human health. Additional research is necessary to elucidate the role of these genes in the pathogenicity of these bacteria.

In addition to the identified virulence genes, WGS analysis revealed previously unreported potential pathogenic genes, such as chemotaxis genes (cheA, cheB, cheR, cheV, cheW, cheY, and cheZ). Chemotaxis genes are closely related to flagella and are recognized as important virulence factors in enteric pathogens. They play crucial roles in pathogenesis and host colonization [35, 36], thereby affecting the virulence and infection potential of pathogenic bacteria [37], which ultimately impacts human health. Our study demonstrated that all seven Aeromonas strains carried chemotaxis genes, suggesting that chemotaxis represents a novel potential pathogenic factor in Aeromonas. These genes have been implicated in colistin resistance in A. hydrophila [38].

Many studies have focused on well-known virulence genes, such as act, aer, hylA, and ast, which are typically detected using PCR. However, this study has revealed the presence of additional virulence determinants, such as waa and che genes, which have received less attention. This demonstrates the ability of WGS to predict the pathogenic genes in seven strains of Aeromonas and provides a novel perspective on understanding the pathogenicity of this bacterium.

The resistance phenotype analysis revealed a significant shift in trends. From 2012 to 2018, all bacterial strains exhibited decreased resistance rates. Nonetheless, a notable surge in resistance was observed in all strains between 2020 and 2022, indicating evolving resistance patterns. Notably, sulfonamide resistance rates steadily increased over the years, indicating that this class of antibiotics should not be overlooked. Moreover, during the 2020–2022 period, all isolates showed higher resistance to CHL and sulfonamides (SMM/SXT) compared to the 2012–2018 period, suggesting a rise in the usage or environmental exposure to these antibiotics over the last few years. A study by Liu et al. [39] detected high concentrations of sulfonamides in fish from the Hangbu-Fengle River, highlighting significant environmental exposure. This exposure may be contributing to the increasing resistance observed in Aeromonas species. It is crucial to raise awareness of Aeromonas as a potential foodborne pathogen threatening human health, as our findings imply a possible increase in the use or exposure to these drugs in the last part of the studied period.

By comparing ARGs carried by different Aeromonas strains over the three time intervals, we observed that the CHL catF gene exhibited the highest and most sustained detection rate. Specifically, this gene was present in 100% of all strains examined, except for A. enteropelogenes, where its detection rate was 66.67%. This finding aligns with the consistently high detection rates of CHL resistance phenotypes observed across the strains. Although China has prohibited the use of CHL in aquaculture since 1999, many studies have indicated that historically, residual CHL resistance genes have persisted and transferred among diverse microbes in aquatic and food environments without significant selective pressure [40, 41]. After CHL, the next highest detection rate was observed for tet resistance genes, which were distributed among all strains in 2012–2022. Various studies have consistently reported the prevalence of different types of tet family genes in water environments, fresh vegetables, and aquatic products [42]. Our study also revealed an increase in the diversity of antibiotic-resistant types and genes over time. Given the widespread use of sulfonamides, quinolones, tetracyclines, and other antibiotics in Chinese aquaculture [43], these changes were possibly affected by changes in the types and habits of drug usage. Although there is diversity in resistance genes, not all resistance phenotypes are expressed, indicating that the presence of various resistance genes does not necessarily correlate with the occurrence of all corresponding resistances.

The study showed no correlation between the antimicrobial resistance phenotypes and genotypes of all strains, suggesting that potential factors contributing to this discrepancy include the limited sample size or insufficient expression of resistance genes. WGS analysis showed that all seven bacterial strains contained multiple resistance genes, including four types of β-lactamase extended-spectrum β-lactamases, labeled A, B, C, and D. This suggests that β-lactamases are prevalent in A. veronii and A. hydrophila. However, CphA is exclusive to A. hydrophila and absent in A. veronii, which was consistent with a previous study [25]. Additionally, the types of resistance genes carried by two strains of A. hydrophila remained consistent over at least two years, indicating stability in their resistance gene profile. Similarly, four strains of A. veronii isolated from different hosts in 2014–2022 consistently carried CRP, mcr-7.1, MexB, and OXA-427, demonstrating a persistent ability to carry resistance genes. Despite the ban on β-lactamase antibiotics in Chinese aquaculture, our WGS results reveal the continued presence of these resistance factors, suggesting the need for further research to assess their potential harm to human health.

China has not officially approved the use of colistin, which can contaminate the aquatic environment through runoff carrying animal excreta containing residual colistin in aquaculture [44, 45]. Additionally, antibiotic environments facilitate horizontal gene transfer among bacteria, amplifying bacterial resistance [46]. Fish and seafood may serve as reservoirs for antibiotic-resistant bacteria, contributing to the spread of ARGs [47-49], particularly since resistant Aeromonas poses a significant public health risk to humans [28].

The primary limitations of this study include the inconsistent number of fish across groups and the varying duration of sample collection. Furthermore, we did not statistically analyze the distribution of Aeromonas spp. in this study. In the future, pathogenicity testing and genomic studies should be conducted to validate A. veronii and A. hydrophila as the principal pathogens.

5. Conclusions

This decade-long study provides critical insights into the diversity, virulence, and antimicrobial resistance profiles of Aeromonas spp. in aquaculture products from Eastern China. The consistent presence of key virulence genes (e.g., aer, lip, and exu) and the increasing prevalence of ARGs (e.g., CHL and sulfonamide resistance genes) highlight the evolving pathogenic potential and environmental adaptability of these bacteria. These findings underscore the importance of continuous surveillance and the need for stringent antibiotic stewardship in aquaculture to mitigate the risk of foodborne infections and preserve the efficacy of existing antimicrobials. The potential for cross-species transmission of high-risk Aeromonas strains further supports the necessity of a One Health approach, integrating efforts across human, animal, and environmental health sectors. Our findings emphasize the urgent need for coordinated, multi-sectoral strategies to address antimicrobial resistance, ensuring the sustainability of aquaculture resources and safeguarding public health.

Institutional Review Board Statement

The animal study protocol was approved by the Institutional Review Board of the Shanghai Fisheries Research Institute (protocol code SFRI-202303).

Acknowledgment

We thank Professor Yonghai Shi, Shanghai Fisheries Research Institute, for support in Aeromonas spp. epidemiology.

Nomenclature

MLST

Multilocus sequence typing

ARG

Antibiotic-resistance gene

WGS

Whole-genome sequencing

ANI

Average nucleotide identity
Appendix

Supplementary Materials: Table S1: All strain species, years, types of virulence genes, and resistance genes; Table S2: ANI details; Table S3: Genome annotation by VFDB(A01); Table S4: Genome annotation by VFDB(A03); Table S5: Genome annotation by VFDB(A04); Table S6: Genome annotation by VFDB(A12); Table S7: Genome annotation by VFDB(A15); Table S8: Genome annotation by VFDB(A16); Table S9: Genome annotation by VFDB(A17); Table S10: Genome annotation by CARD(A01); Table S11: Genome annotation by CARD(A03); Table S12: Genome annotation by CARD(A04); Table S13: Genome annotation by CARD(A12); Table S14: Genome annotation by CARD(A15); Table S15: Genome annotation by CARD(A16); Table S16: Genome annotation by CARD(A17).

Table S1. All strain species, years, the types of virulence genes and resistance genes

Number

Species

Year

Sources

Virulence Genes

Virulence Types

Number

1

Aeromonas veronii

2013

Yellow Catfish

aer,ast,lip,act,gcaT,eprCAI,ahyB,exu,alt

II

A02

2

Aeromonas veronii

2014

Litopenaeus Vannamei

aer,lip,act,exu

II

A03(ST1113)

3

Aeromonas veronii

2013

Silver Carp

aer,lip,act,exu,alt

II

A05

4

Aeromonas veronii

2013

Black Carp

aer,lip,act,exu

II

A06

5

Aeromonas veronii

2021

Grass Carp

aer,lip,act,exu

II

A07

6

Aeromonas veronii

2014

Perch

aer,lip,act,exu

II

A10

7

Aeromonas veronii

2013

Silver Carp

aer,lip,act,ahyB,exu

II

A13

8

Aeromonas veronii

2013

Crucian Carp

lip,exu

IV

A70

9

Aeromonas veronii

2015

Litopenaeus Vannamei

aer,lip,act,exu,alt

II

A18

10

Aeromonas veronii

2014

Litopenaeus Vannamei

aer,lip,act,fla,exu,alt

I

A15(ST2386)

11

Aeromonas veronii

2015

Litopenaeus Vannamei

aer,lip,act,gcaT,fla,ahyB,exu,alt

I

A16(ST903)

12

Aeromonas veronii

2016

Perch

aer,ast,lip,eprCAI,gcaT,fla,ahyB,exu,alt

I

A20

13

Aeromonas veronii

2021

Grass Carp

aer,ast,lip,act,eprCAI,fla,ahyB,exu,alt

I

A22

14

Aeromonas veronii

2018

Black Carp

aer,ast,lip,ahyB,exu,alt

II

A23

15

Aeromonas veronii

2018

Catfish

aer,lip,eprCAI,fla,exu,alt

I

A25

16

Aeromonas veronii

2020

Litopenaeus Vannamei

aer,lip,fla,exu,alt

I

A26

17

Aeromonas veronii

2021

Litopenaeus Vannamei

aer,lip,eprCAI,fla,ahyB,exu,alt

I

A33

18

Aeromonas veronii

2021

Litopenaeus Vannamei

aer,lip,eprCAI,fla,ahyB,exu,alt

I

A34

19

Aeromonas veronii

2022

Crucian Carp

aer,lip,eprCAI,fla,exu,alt

I

A41

20

Aeromonas veronii

2022

Crucian Carp

aer,lip,fla,exu

I

A43

21

Aeromonas veronii

2022

Crucian Carp

aer,lip,eprCAI,gcaT,fla,ahyB,exu,alt

I

A17(ST1114)

22

Aeromonas veronii

2022

Crucian Carp

aer,lip,fla,exu,alt

I

A47

23

Aeromonas veronii

2022

Litopenaeus Vannamei

aer,lip,fla,exu,alt

I

A48

24

Aeromonas veronii

2022

Litopenaeus Vannamei

aer,lip,fla,ahyB,exu,alt

I

A49

25

Aeromonas veronii

2022

Litopenaeus Vannamei

aer,lip,act,eprCAI,fla,ahyB,exu,alt

I

A50

26

Aeromonas veronii

2022

Crucian Carp

aer,lip,eprCAI,fla

I

A51

27

Aeromonas veronii

2022

Litopenaeus Vannamei

aer,lip,fla

I

A55

28

Aeromonas veronii

2022

Crucian Carp

aer,lip,act,eprCAI,fla,exu,alt

I

A59

29

Aeromonas veronii

2022

Crucian Carp

aer,lip,act,eprCAI,fla,exu,alt

I

A60

30

Aeromonas veronii

2022

Crucian Carp

aer,lip,act,eprCAI,fla,exu,alt

I

A61

31

Aeromonas veronii

2022

Perch

aer,lip,fla,alt

I

A62

32

Aeromonas veronii

2022

Black Carp

aer,lip,act,eprCAI,fla,exu,alt

I

A69

1

Aeromonas sobria

2021

Grass Carp

aer,fla,exu,alt

I

A09

2

Aeromonas sobria

2016

Mandarin Fish

aer,eprCAI,fla,exu,alt

I

A19

3

Aeromonas sobria

2018

Crucian Carp

aer,lip,eprCAI,fla,exu,alt

I

A24

4

Aeromonas sobria

2020

Crucian Carp

aer,lip,eprCAI,fla,exu,alt

I

A27

5

Aeromonas sobria

2020

Grass Carp

aer,lip,eprCAI,fla,exu,alt

I

A28

6

Aeromonas sobria

2021

Grass Carp

aer,lip,fla

I

A29

7

Aeromonas sobria

2021

Grass Carp

aer,lip,fla,ahyB,exu,alt

I

A30

8

Aeromonas sobria

2021

Grass Carp

aer,lip,fla,ahyB

I

A31

9

Aeromonas sobria

2022

Crucian Carp

aer,lip,fla,ahyB,exu,alt

I

A39

10

Aeromonas sobria

2022

Crucian Carp

aer,lip,fla,ahyB,exu,alt

I

A53

11

Aeromonas sobria

2022

Crucian Carp

lip,fla,ahyB,exu,alt

I

A58

12

Aeromonas sobria

2022

Crucian Carp

aer,lip,exu,alt

II

A64

13

Aeromonas sobria

2022

Litopenaeus Vannamei

lip,fla,ahyB,exu,alt

I

A67

14

Aeromonas sobria

2022

Litopenaeus Vannamei

aer,lip,ahyB,exu,alt

I

A68

1

Aeromonas hydrophila

2012

Mandarin Fish

aer,lip,fla,exu,alt

I

A1(ST1826)

2

Aeromonas hydrophila

2013

Crucian Carp

aer,lip,fla,exu,alt

I

A12(ST1826)

3

Aeromonas hydrophila

2013

Black Carp

aer,fla,exu,alt

I

A14

4

Aeromonas hydrophila

2021

Grass Carp

aer,lip,fla,exu,alt

I

A4(ST1124)

5

Aeromonas hydrophila

2022

Mandarin Fish

aer,lip,fla,ahyB

I

A54

6

Aeromonas hydrophila

2022

Litopenaeus Vannamei

aer,ahyB

II

A56

7

Aeromonas hydrophila

2022

Crucian Carp

aer,fla,exu,alt

I

A63

1

Aeromonas enteropelogenes

2021

Grass Carp

aer,fla

III

A35

2

Aeromonas enteropelogenes

2022

Black Carp

aer,lip,fla,exu,alt

I

A36

3

Aeromonas enteropelogenes

2022

Litopenaeus Vannamei

aer,lip,act

II

A37

4

Aeromonas enteropelogenes

2022

Crucian Carp

aer,lip,fla,ahyB,exu,alt

I

A38

5

Aeromonas enteropelogenes

2022

Crucian Carp

aer,lip,fla,ahyB,exu,alt

I

A40

6

Aeromonas enteropelogenes

2022

Crucian Carp

aer,lip,act

II

A45

1

Aeromonas salmonicida

2018

Black Carp

aer,lip,exu,alt

II

A21

2

Aeromonas salmonicida

2022

Crucian Carp

aer,lip

II

A57

3

Aeromonas salmonicida

2022

Litopenaeus Vannamei

aer,ast,lip,fla,ahyB,exu,alt

I

A65

1

Aeromonas jandaei

2022

Crucian Carp

aer,lip,act,fla,exu,alt

I

A42

2

Aeromonas jandaei

2022

Crucian Carp

aer,lip,fla,exu,alt

I

A52

1

Aeromonas caviae

2014

Perch

aer,lip,act,fla,exu,alt

I

A08

2

Aeromonas caviae

2022

Crucian Carp

aer,lip

II

A44

3

Aeromonas caviae

2022

Crucian Carp

aer,lip,fla,exu,alt

I

A46

1

Aeromonas bestiarum

2021

Grass Carp

aer,lip,act,exu

II

A32

Table S2. ANI details

Strain

Species

GenBank

RefSeq

Aeromonas allosaccharophila strain K520 chromosome, complete genome

Aeromonas allosaccharophila

CP118988.1

GCF_029024985.1

Aeromonas caviae KAM643 DNA, complete genome

Aeromonas caviae

AP026403.1

GCF_024347775.1

Aeromonas caviae KAM497 DNA, complete genome

Aeromonas caviae

AP026375.1

GCF_024347715.1

Aeromonas caviae KAM471 DNA, complete genome

Aeromonas caviae

AP026370.1

GCF_024347695.1

Aeromonas caviae strain 1605-27183 chromosome, complete genome

Aeromonas caviae

CP047983.1

GCF_013488005.1

Aeromonas caviae strain NCTC12244 genome assembly, chromosome: 1

Aeromonas caviae

LS483441.1

GCF_900476005.1

Aeromonas encheleia strain NCTC12917 genome assembly, chromosome: 1

Aeromonas encheleia

LR134376.1

GCF_900637545.1

Aeromonas encheleia strain SOD01 chromosome, complete genome

Aeromonas encheleia

CP099717.1

GCF_024112375.1

Aeromonas hydrophila strain 516 chromosome, complete genome

Aeromonas hydrophila

CP119764.1

GCF_029320915.1

Aeromonas hydrophila strain K533 chromosome, complete genome

Aeromonas hydrophila

CP118942.1

GCF_029025785.1

Aeromonas hydrophila strain K522 chromosome, complete genome

Aeromonas hydrophila

CP118699.1

GCF_028994095.1

Aeromonas hydrophila strain BC19 chromosome, complete genome

Aeromonas hydrophila

CP102370.1

GCF_026651545.1

Aeromonas hydrophila strain BC16 chromosome, complete genome

Aeromonas hydrophila

CP102366.1

GCF_026651505.1

Aeromonas hydrophila strain BC13 chromosome, complete genome

Aeromonas hydrophila

CP102364.1

GCF_026651445.1

Aeromonas hydrophila strain NEB724 chromosome, complete genome

Aeromonas hydrophila

CP050994.1

  

Aeromonas hydrophila strain 23-C-23 chromosome, complete genome

Aeromonas hydrophila

CP038465.1

GCF_004684325.1

Aeromonas hydrophila strain WCX23 chromosome, complete genome

Aeromonas hydrophila

CP038463.1

GCF_004684305.1

Aeromonas hydrophila strain WCX23 chromosome, complete genome

Aeromonas hydrophila

CP028418.1

  

Aeromonas hydrophila strain Til1 16S ribosomal RNA gene, partial sequence

Aeromonas hydrophila

MT384379.1

  

Aeromonas hydrophila strain LHW39 chromosome, complete genome

Aeromonas hydrophila

CP050012.1

  

Aeromonas hydrophila strain HX-3 chromosome, complete genome

Aeromonas hydrophila

CP046954.1

  

Aeromonas hydrophila strain TL7 16S ribosomal RNA gene, partial sequence

Aeromonas hydrophila

MN493074.1

  

Aeromonas hydrophila strain ZYAH72 chromosome, complete genome

Aeromonas hydrophila

CP016989.1

  

Aeromonas hydrophila GSH8-2 DNA, complete genome

Aeromonas hydrophila

AP019193.1

  

Aeromonas jandaei strain BC17 chromosome, complete genome

Aeromonas jandaei

CP102367.1

GCF_026651485.1

Aeromonas media strain R50-22 chromosome, complete genome

Aeromonas media

CP038448.1

GCF_013085785.1

Aeromonas media strain R25-3 chromosome, complete genome

Aeromonas media

CP038445.1

GCF_013085765.1

Aeromonas media strain K521 chromosome, complete genome

Aeromonas media

CP118993.1

GCF_029025005.1

Aeromonas media strain T5-8 chromosome, complete genome

Aeromonas media

CP038444.1

GCF_013085745.1

Aeromonas media strain R1-18 chromosome, complete genome

Aeromonas media

CP038443.1

  

Aeromonas media strain MC64 16S ribosomal RNA gene, partial sequence

Aeromonas media

MT103436.1

  

Aeromonas media strain MC64 chromosome, complete genome

Aeromonas media

CP047962.1

GCF_009931135.1

Aeromonas media strain T0.1-19 chromosome, complete genome

Aeromonas media

CP038441.1

GCF_013085485.1

Aeromonas media strain T5-1 chromosome, complete genome

Aeromonas media

CP061477.1

  

Aeromonas media WS, complete genome

Aeromonas media WS

CP007567.1

GCF_000287215.2

Aeromonas rivipollensis strain KN-Mc-11N1 chromosome, complete genome

Aeromonas rivipollensis

CP027856.1

GCF_003015165.1

Aeromonas salmonicida strain ZAS chromosome, complete genome

Aeromonas salmonicida

CP110647.1

GCF_028355815.1

Aeromonas salmonicida strain A527 chromosome, complete genome

Aeromonas salmonicida

CP022550.1

GCF_002764135.1

Aeromonas salmonicida strain S68, complete genome

Aeromonas salmonicida

CP022186.1

GCF_002214265.1

Aeromonas salmonicida strain S44, complete genome

Aeromonas salmonicida

CP022181.1

GCF_002214305.1

Aeromonas salmonicida subsp. masoucida strain RFAS1 chromosome, complete genome

Aeromonas salmonicida subsp. masoucida

CP017143.1

GCF_002313065.1

Aeromonas salmonicida subsp. pectinolytica 34mel chromosome, complete genome

Aeromonas salmonicida subsp. pectinolytica 34mel

CP022426.1

GCF_002735225.1

Aeromonas salmonicida subsp. salmonicida strain J411 chromosome, complete genome

Aeromonas salmonicida subsp. salmonicida

CP052034.1

GCA_012933685.1

Aeromonas salmonicida subsp. salmonicida strain J223 chromosome, complete genome

Aeromonas salmonicida subsp. salmonicida

CP048223.1

GCF_001643275.2

Aeromonas salmonicida subsp. salmonicida strain J410 chromosome, complete genome

Aeromonas salmonicida subsp. salmonicida

CP047376.1

GCF_009858135.1

Aeromonas salmonicida subsp. salmonicida strain J409 chromosome, complete genome

Aeromonas salmonicida subsp. salmonicida

CP047374.1

  

Aeromonas salmonicida subsp. salmonicida 01-B526 chromosome, complete genome

Aeromonas salmonicida subsp. salmonicida 01-B526

CP027000.1

  

Aeromonas veronii strain AV066 chromosome, complete genome

Aeromonas veronii

CP126578.1

GCF_030178455.1

Aeromonas veronii strain C4 chromosome, complete genome

Aeromonas veronii

CP110364.1

GCF_026016025.1

Aeromonas veronii strain ZfB1 chromosome, complete genome

Aeromonas veronii

CP034967.1

GCF_011045495.1

Aeromonas veronii strain AVNIH1 chromosome, complete genome

Aeromonas veronii

CP047155.1

GCF_009834065.1

Aeromonas veronii strain HX3 chromosome, complete genome

Aeromonas veronii

CP040717.1

GCF_009755745.1

Aeromonas veronii strain FDAARGOS_632 chromosome, complete genome

Aeromonas veronii

CP044060.1

GCF_008693705.1

Aeromonas veronii strain MS-18-37 chromosome, complete genome

Aeromonas veronii

CP033604.1

GCF_003722175.1

Aeromonas veronii strain FC951 chromosome, complete genome

Aeromonas veronii

CP032839.1

GCF_002866885.2

Aeromonas veronii strain Colony108 chromosome

Aeromonas veronii

CP070210.1

GCF_016902815.1

Aeromonas veronii strain AS1 chromosome, complete genome

Aeromonas veronii

CP114182.1

GCF_030609635.1

Aeromonas veronii strain YOR 16989 chromosome, complete genome

Aeromonas veronii

CP121810.1

  

Aeromonas veronii strain 71506 chromosome, complete genome

Aeromonas veronii

CP085465.1

GCF_020640955.1

Aeromonas veronii strain HS1906 chromosome, complete genome

Aeromonas veronii

CP133079.1

  

Aeromonas veronii strain ANYA 18197 chromosome, complete genome

Aeromonas veronii

CP121840.1

  

Aeromonas veronii strain A8-AHP chromosome, complete genome

Aeromonas veronii

CP046407.1

  

Aeromonas veronii strain 17ISAe chromosome, complete genome

Aeromonas veronii

CP028133.1

  

Aeromonas veronii strain X12 chromosome, complete genome

Aeromonas veronii

CP024933.1

  

Aeromonas veronii strain X11 chromosome, complete genome

Aeromonas veronii

CP024930.1

  

Aeromonas veronii strain BIM B-1812 chromosome, complete genome

Aeromonas veronii

CP136589.1

  

Aeromonas veronii strain AVNIH1, complete genome

Aeromonas veronii

CP014774.1

  

Aeromonas sp. CA23 chromosome, complete genome

Aeromonas sp.

CP023818.1

GCF_002587065.1

Table S3. Genome annotation by VFDB(A01)

Query-Name Hit-Name Description
gene45 VFG038908(gb|YP_857708) (AHA_3217) thermostable hemolysin [Thermostable hemolysin (TH) (CVF794)] [Aeromonas hydrophila subsp. hydrophila ATCC 7966]
gene68 VFG038443(gb|YP_857685) (tapM) type IV pilus assembly protein PilM [Tap type IV pili (CVF783)] [Aeromonas hydrophila subsp. hydrophila ATCC 7966]
gene69 VFG038447(gb|YP_857684) (tapN) type IV pilus biogenesis protein PilN [Tap type IV pili (CVF783)] [Aeromonas hydrophila subsp. hydrophila ATCC 7966]
gene70 VFG038451(gb|YP_857683) (tapO) type IV pilus biogenesis protein PilO [Tap type IV pili (CVF783)] [Aeromonas hydrophila subsp. hydrophila ATCC 7966]
gene71 VFG038455(gb|YP_857682) (tapP) type IV pilus biogenesis protein PilP [Tap type IV pili (CVF783)] [Aeromonas hydrophila subsp. hydrophila ATCC 7966]
gene72 VFG038459(gb|YP_857681) (tapQ) type IV pilus secretin PilQ [Tap type IV pili (CVF783)] [Aeromonas hydrophila subsp. hydrophila ATCC 7966]
gene109 VFG013465(gb|NP_439706) (kdsA) 2-dehydro-3-deoxyphosphooctonate aldolase [LOS (CVF494)] [Haemophilus influenzae Rd KW20]
gene364 VFG007659(gi:59710773) (rmlB) dTDP-glucose 4,6-dehydratase [Capsular polysaccharide (CVF282)] [Vibrio fischeri ES114]
gene366 VFG018664(gi:157151373) (rfbA-1) glucose-1-phosphate thymidylyltransferase [Capsule (CVF186)] [Streptococcus gordonii str. Challis substr. CH1]
gene420 VFG038827(gb|YP_857351) (flgN) flagellar protein FlgN [ND (AI144)] [Aeromonas hydrophila subsp. hydrophila ATCC 7966]
gene421 VFG038823(gb|YP_857350) (flgM) anti-sigma-D factor [ND (AI144)] [Aeromonas hydrophila subsp. hydrophila ATCC 7966]
gene422 VFG038819(gb|YP_857349) (flgA) flagella basal body P-ring formation protein FlgA [ND (AI144)] [Aeromonas hydrophila subsp. hydrophila ATCC 7966]
gene423 VFG038815(gb|YP_857348) (cheV) CheV [ND (AI144)] [Aeromonas hydrophila subsp. hydrophila ATCC 7966]
gene424 VFG038811(gb|YP_857347) (cheR-3) chemotaxis protein CheR [ND (AI144)] [Aeromonas hydrophila subsp. hydrophila ATCC 7966]
gene425 VFG038807(gb|YP_857346) (flgB) flagellar basal-body rod protein FlgB [ND (AI144)] [Aeromonas hydrophila subsp. hydrophila ATCC 7966]
gene426 VFG038803(gb|YP_857345) (flgC) flagellar basal body rod protein FlgC [ND (AI144)] [Aeromonas hydrophila subsp. hydrophila ATCC 7966]
gene427 VFG038799(gb|YP_857344) (flgD) flagellar hook capping protein [ND (AI144)] [Aeromonas hydrophila subsp. hydrophila ATCC 7966]
gene428 VFG038796(gi:507522559) (flgE) flagellar hook protein FlgE [Polar flagella (VF0473)] [Aeromonas hydrophila ML09-119]
gene430 VFG038791(gb|YP_857342) (flgF) flagellar basal-body rod protein FlgF [ND (AI144)] [Aeromonas hydrophila subsp. hydrophila ATCC 7966]
gene431 VFG038787(gb|YP_857341) (flgG) flagellar basal body rod protein FlgG [ND (AI144)] [Aeromonas hydrophila subsp. hydrophila ATCC 7966]
gene432 VFG038783(gb|YP_857340) (flgH) flagellar basal body L-ring protein [ND (AI144)] [Aeromonas hydrophila subsp. hydrophila ATCC 7966]
gene433 VFG038779(gb|YP_857339) (flgI) flagellar basal body P-ring protein [ND (AI144)] [Aeromonas hydrophila subsp. hydrophila ATCC 7966]
gene434 VFG038776(gi:507522554) (flgJ) flagellar rod assembly protein/muramidase FlgJ [Polar flagella (VF0473)] [Aeromonas hydrophila ML09-119]
gene435 VFG038771(gb|YP_857337) (flgK) flagellar hook-associated protein FlgK [ND (AI144)] [Aeromonas hydrophila subsp. hydrophila ATCC 7966]
gene436 VFG038768(gi:507522552) (flgL) flagellar hook-associated protein FlgL [Polar flagella (VF0473)] [Aeromonas hydrophila ML09-119]
gene442 VFG038763(gb|YP_857330) (fleQ/flrC) FleQ protein [ND (AI144)] [Aeromonas hydrophila subsp. hydrophila ATCC 7966]
gene443 VFG038759(gb|YP_857329) (fleS/flrB) two-component sensor kinase [ND (AI144)] [Aeromonas hydrophila subsp. hydrophila ATCC 7966]
gene444 VFG038755(gb|YP_857328) (fleR/flrC) transcriptional activator [ND (AI144)] [Aeromonas hydrophila subsp. hydrophila ATCC 7966]
gene459 VFG038900(gb|YP_857314) (hlyA) Hemolysin A [Hemolysin HlyA (CVF792)] [Aeromonas hydrophila subsp. hydrophila ATCC 7966]
gene493 VFG038845(gi:507522470) (nueA) flagellar-related 3-deoxy-D-manno-octulosonate cytidylyltransferase [Polar flagella (VF0473)] [Aeromonas hydrophila ML09-119]
gene543 VFG038615(gi:507519898) (mshI) MSHA biogenesis protein MshI [MSHA type IV pili (VF0477)] [Aeromonas hydrophila ML09-119]
gene544 VFG038610(gb|YP_854916) (mshI1) MSHA (mannose-sensitive hemagglutinin) pili biogenesis protein MshI1, bitopic inner membrane protein [Mannose-sensitive hemagglutinin (Msh) pilus, type IV pili (CVF785)] [Aeromonas hydrophila subsp. hydrophila ATCC 7966]
gene545 VFG038606(gb|YP_854917) (mshJ) MSHA (mannose-sensitive hemagglutinin) pili biogenesis protein MshJ, bitopic inner membrane protein, GspM-like [Mannose-sensitive hemagglutinin (Msh) pilus, type IV pili (CVF785)] [Aeromonas hydrophila subsp. hydrophila ATCC 7966]
gene546 VFG038603(gb|YP_008041515) (mshK) MSHA (mannose-sensitive hemagglutinin) pili biogenesis protein MshK, periplasmic protein, GspC-like [MSHA type IV pili (VF0477)] [Aeromonas hydrophila ML09-119]
gene547 VFG038599(gb|YP_854918) (mshL) MSHA (mannose-sensitive hemagglutinin) pili biogenesis protein MshL, outer membrane secretin, GspD-like [Mannose-sensitive hemagglutinin (Msh) pilus, type IV pili (CVF785)] [Aeromonas hydrophila subsp. hydrophila ATCC 7966]
gene548 VFG038595(gb|YP_854919) (mshM) membrane protein with ATPase domain, GspA-like [Mannose-sensitive hemagglutinin (Msh) pilus, type IV pili (CVF785)] [Aeromonas hydrophila subsp. hydrophila ATCC 7966]
gene549 VFG038593(gi:507519904) (mshN) hypothetical protein [MSHA type IV pili (VF0477)] [Aeromonas hydrophila ML09-119]
gene550 VFG038589(gb|YP_854921) (mshE) ATPase protein MshE, GspE-like [Mannose-sensitive hemagglutinin (Msh) pilus, type IV pili (CVF785)] [Aeromonas hydrophila subsp. hydrophila ATCC 7966]
gene551 VFG038586(gb|YP_854922) (mshG) MSHA (mannose-sensitive hemagglutinin) pili biogenesis protein MshG, GspF-like [Mannose-sensitive hemagglutinin (Msh) pilus, type IV pili (CVF785)] [Aeromonas hydrophila subsp. hydrophila ATCC 7966]
gene552 VFG038583(gi:117619824) (mshF) hypothetical protein [Mannose-sensitive hemagglutinin (Msh) pilus, type IV pili (CVF785)] [Aeromonas hydrophila subsp. hydrophila ATCC 7966]
gene553 VFG038580(gb|YP_854924) (mshB) MSHA (mannose-sensitive hemagglutinin) pili minor prepilin protein MshB [Mannose-sensitive hemagglutinin (Msh) pilus, type IV pili (CVF785)] [Aeromonas hydrophila subsp. hydrophila ATCC 7966]
gene555 VFG038575(gb|YP_854925) (mshC) MSHA (mannose-sensitive hemagglutinin) pili minor prepilin protein MshC [Mannose-sensitive hemagglutinin (Msh) pilus, type IV pili (CVF785)] [Aeromonas hydrophila subsp. hydrophila ATCC 7966]
gene594 VFG038891(gb|YP_854967) (aerA/act) Aerolysin A [aerolysin (TX450)] [Aeromonas hydrophila subsp. hydrophila ATCC 7966]
gene595 VFG038892(gi:507519971) (aerA/act) aerolysin [Aerolysin (VF0481)] [Aeromonas hydrophila ML09-119]
gene596 VFG038892(gi:507519971) (aerA/act) aerolysin [Aerolysin (VF0481)] [Aeromonas hydrophila ML09-119]
gene681 VFG038409(gi:507520051) (fimA) fimbrial protein [Type I pili (VF0486)] [Aeromonas hydrophila ML09-119]
gene683 VFG038412(gb|YP_855054) (fimC) outer membrane usher protein [Type I fimbriae (CVF796)] [Aeromonas hydrophila subsp. hydrophila ATCC 7966]
gene684 VFG038417(gi:507520054) (fimD) fimbrial chaperone protein [Type I pili (VF0486)] [Aeromonas hydrophila ML09-119]
gene685 VFG038423(gi:330828179) (fimE) type I pilus assembly protein FimE [Type I fimbriae (CVF796)] [Aeromonas veronii B565]
gene686 VFG038424(gb|YP_855057) (fimF) fimbrial protein [Type I fimbriae (CVF796)] [Aeromonas hydrophila subsp. hydrophila ATCC 7966]
gene730 VFG038268(gb|YP_855101) (exeC) general secretion pathway protein C [exe (SS209)] [Aeromonas hydrophila subsp. hydrophila ATCC 7966]
gene731 VFG038272(gb|YP_855102) (exeD) general secretion pathway protein D [exe (SS209)] [Aeromonas hydrophila subsp. hydrophila ATCC 7966]
gene732 VFG038277(gi:507520101) (exeE) general secretory pathway protein E [Exe T2SS (VF0478)] [Aeromonas hydrophila ML09-119]
gene733 VFG038280(gb|YP_855104) (exeF) general secretion pathway protein F [exe (SS209)] [Aeromonas hydrophila subsp. hydrophila ATCC 7966]
gene734 VFG038284(gb|YP_855105) (exeG) general secretion pathway protein G [exe (SS209)] [Aeromonas hydrophila subsp. hydrophila ATCC 7966]
gene735 VFG038289(gi:507520105) (exeH) general secretion pathway protein H [Exe T2SS (VF0478)] [Aeromonas hydrophila ML09-119]
gene736 VFG038293(gi:507520106) (exeI) general secretion pathway protein I [Exe T2SS (VF0478)] [Aeromonas hydrophila ML09-119]
gene737 VFG038296(gb|YP_855108) (exeJ) general secretion pathway protein J [exe (SS209)] [Aeromonas hydrophila subsp. hydrophila ATCC 7966]
gene738 VFG038300(gb|YP_855109) (exeK) general secretion pathway protein K [exe (SS209)] [Aeromonas hydrophila subsp. hydrophila ATCC 7966]
gene739 VFG038304(gb|YP_855110) (exeL) general secretion pathway protein L [exe (SS209)] [Aeromonas hydrophila subsp. hydrophila ATCC 7966]
gene740 VFG038309(gi:507520110) (exeM) general secretion pathway protein M [Exe T2SS (VF0478)] [Aeromonas hydrophila ML09-119]
gene741 VFG038312(gb|YP_855112) (exeN) general secretion pathway protein N [exe (SS209)] [Aeromonas hydrophila subsp. hydrophila ATCC 7966]
gene824 VFG038618(gb|YP_855202) (motX) sodium-type flagellar motor component [Polar flagella (CVF786)] [Aeromonas hydrophila subsp. hydrophila ATCC 7966]
gene851 VFG038492(gb|YP_855228) (tppE) type IV pilus pseudopilin [Tap type IV pili (CVF783)] [Aeromonas hydrophila subsp. hydrophila ATCC 7966]
gene852 VFG038480(gi:507520223) (tppB) type IV pilus modification protein [Tap type IV pili (VF0475)] [Aeromonas hydrophila ML09-119]
gene855 VFG038488(gi:507520226) (tapY) type IV pilus biogenesis protein [Tap type IV pili (VF0475)] [Aeromonas hydrophila ML09-119]
gene856 VFG038476(gi:507520227) (tppA) type IV pilus related protein [Tap type IV pili (VF0475)] [Aeromonas hydrophila ML09-119]
gene865 VFG018241(gb|NP_230208) (luxS) S-ribosylhomocysteinase [AI-2 (VF0406)] [Vibrio cholerae O1 biovar El Tor str. N16961]
gene954 VFG038622(gb|YP_855903) (fliE) flagellar hook-basal body complex protein FliE [ND (AI144)] [Aeromonas hydrophila subsp. hydrophila ATCC 7966]
gene955 VFG038627(gi:507520997) (fliF) flagellar MS-ring protein [Polar flagella (VF0473)] [Aeromonas hydrophila ML09-119]
gene956 VFG038630(gb|YP_855905) (fliG) flagellar motor switch protein G [ND (AI144)] [Aeromonas hydrophila subsp. hydrophila ATCC 7966]
gene957 VFG038635(gi:507520999) (fliH) flagellar assembly protein FliH [Polar flagella (VF0473)] [Aeromonas hydrophila ML09-119]
gene958 VFG038638(gb|YP_855907) (fliI) flagellum-specific ATP synthase [ND (AI144)] [Aeromonas hydrophila subsp. hydrophila ATCC 7966]
gene959 VFG038642(gb|YP_855908) (fliJ) flagellar export protein FliJ [ND (AI144)] [Aeromonas hydrophila subsp. hydrophila ATCC 7966]
gene960 VFG038647(gi:507521002) (fliK) flagellar hook-length control protein FliK [Polar flagella (VF0473)] [Aeromonas hydrophila ML09-119]
gene961 VFG038650(gb|YP_855910) (fliL) flagellar basal body-associated protein FliL [ND (AI144)] [Aeromonas hydrophila subsp. hydrophila ATCC 7966]
gene962 VFG038654(gb|YP_855911) (fliM) flagellar motor switch protein FliM [ND (AI144)] [Aeromonas hydrophila subsp. hydrophila ATCC 7966]
gene963 VFG038658(gb|YP_855912) (fliN) flagellar motor switch protein FliN [ND (AI144)] [Aeromonas hydrophila subsp. hydrophila ATCC 7966]
gene964 VFG038662(gb|YP_855913) (fliO) flagellar biosynthesis protein, FliO [ND (AI144)] [Aeromonas hydrophila subsp. hydrophila ATCC 7966]
gene965 VFG038667(gi:507521007) (fliP) flagellar biosynthesis protein FliP [Polar flagella (VF0473)] [Aeromonas hydrophila ML09-119]
gene966 VFG038670(gb|YP_855915) (fliQ) flagellar biosynthetic protein FliQ [ND (AI144)] [Aeromonas hydrophila subsp. hydrophila ATCC 7966]
gene967 VFG038674(gb|YP_855916) (fliR) flagellar biosynthesis protein FliR [ND (AI144)] [Aeromonas hydrophila subsp. hydrophila ATCC 7966]
gene968 VFG038679(gi:507521010) (flhB) flagellar biosynthetic protein FlhB [Polar flagella (VF0473)] [Aeromonas hydrophila ML09-119]
gene969 VFG038683(gi:507521011) (flhA) flagellar biosynthesis protein FlhA [Polar flagella (VF0473)] [Aeromonas hydrophila ML09-119]
gene970 VFG038687(gi:507521012) (flhF) flagellar biosynthesis protein FlhF [Polar flagella (VF0473)] [Aeromonas hydrophila ML09-119]
gene971 VFG038691(gi:507521013) (flhG) flagellar-related protein [Polar flagella (VF0473)] [Aeromonas hydrophila ML09-119]
gene972 VFG038694(gb|YP_855921) (fliA) flagellar biosynthesis sigma factor [ND (AI144)] [Aeromonas hydrophila subsp. hydrophila ATCC 7966]
gene973 VFG038698(gb|YP_855922) (cheY) chemotaxis protein CheY [ND (AI144)] [Aeromonas hydrophila subsp. hydrophila ATCC 7966]
gene974 VFG038702(gb|YP_855923) (cheZ) chemotaxis protein CheZ [ND (AI144)] [Aeromonas hydrophila subsp. hydrophila ATCC 7966]
gene975 VFG038707(gi:507521017) (cheA) flagellar-related chemotaxis protein CheA [Polar flagella (VF0473)] [Aeromonas hydrophila ML09-119]
gene976 VFG038710(gb|YP_855925) (cheB-2) chemotaxis-specific methylesterase [ND (AI144)] [Aeromonas hydrophila subsp. hydrophila ATCC 7966]
gene977 VFG038714(gb|YP_855926) (motA) chemotaxis protein MotA [ND (AI144)] [Aeromonas hydrophila subsp. hydrophila ATCC 7966]
gene978 VFG038719(gi:507521020) (pomB) flagellar-related chemotaxis protein [Polar flagella (VF0473)] [Aeromonas hydrophila ML09-119]
gene979 VFG038722(gb|YP_855928) (AHA_1389) CobQ/CobB/MinD/ParA family protein [Polar flagella (CVF786)] [Aeromonas hydrophila subsp. hydrophila ATCC 7966]
gene980 VFG038726(gb|YP_855929) (cheW) chemotaxis protein CheW [Polar flagella (CVF786)] [Aeromonas hydrophila subsp. hydrophila ATCC 7966]
gene981 VFG043204(gb|YP_855930) (cheW-2) chemotaxis protein CheW [ND (AI144)] [Aeromonas hydrophila subsp. hydrophila ATCC 7966]
gene1101 VFG038898(gi:507521195) (ahh1) hemolysin [Extracellular hemolysin AHH1 (CVF791)] [Aeromonas hydrophila ML09-119]
gene1120 VFG000478(gi:16764063) (fur) transcriptional repressor of iron-responsive genes (Fur family) (ferric uptake regulator) [Fur (VF0113)] [Salmonella enterica subsp. enterica serovar Typhimurium str. LT2]
gene1163 VFG013171(gi:170719013) (gmhA/lpcA) phosphoheptose isomerase [LOS (CVF494)] [Haemophilus somnus 2336]
gene1250 VFG045727(gi:289165404) (csrA) global regulator CsrA [Carbon storage regulator A (CVF362)] [Legionella longbeachae NSW150]
gene1320 VFG038261(gi:507523517) (exeA) general secretion pathway protein A [Exe T2SS (VF0478)] [Aeromonas hydrophila ML09-119]
gene1321 VFG038265(gi:507523518) (exeB) general secretion pathway protein B [Exe T2SS (VF0478)] [Aeromonas hydrophila ML09-119]
gene1397 VFG038432(gi:507523593) (tapB) type IV pilus assembly ATPase [Tap type IV pili (VF0475)] [Aeromonas hydrophila ML09-119]
gene1398 VFG038435(gb|YP_858309) (tapC) type IV fimbrial assembly protein, PilC-like [Tap type IV pili (CVF783)] [Aeromonas hydrophila subsp. hydrophila ATCC 7966]
gene1399 VFG038317(gi:507523595) (tapD) prepilin peptidase [Exe T2SS (VF0478)] [Aeromonas hydrophila ML09-119]
gene1425 VFG038890(gb|YP_001140314) (lafU) LafU, chemotaxis protein [Lateral flagella (VF0474)] [Aeromonas salmonicida subsp. salmonicida A449]
gene1426 VFG038889(gb|YP_001140313) (lafT) LafT, flagella motor stator protein [Lateral flagella (VF0474)] [Aeromonas salmonicida subsp. salmonicida A449]
gene1427 VFG043201(gi:13446369) (lafS) RNA polymerase sigma factor [ND (AI143)] [Aeromonas hydrophila str. AH-3]
gene1428 VFG038887(gb|YP_001140311) (lafF) LafF [Lateral flagella (VF0474)] [Aeromonas salmonicida subsp. salmonicida A449]
gene1430 VFG038885(gb|YP_001140309) (lafX) LafX [Lateral flagella (VF0474)] [Aeromonas salmonicida subsp. salmonicida A449]
gene1431 VFG043197(gi:13446365) (lafC) LafC [ND (AI143)] [Aeromonas hydrophila str. AH-3]
gene1432 VFG038883(gb|YP_001140307) (lafB) flagellar hook associated protein LafB [Lateral flagella (VF0474)] [Aeromonas salmonicida subsp. salmonicida A449]
gene1433 VFG043195(gb|AAK20919) (lafA) lateral flagellin LafA [ND (AI143)] [Aeromonas hydrophila str. AH-3]
gene1434 VFG043195(gb|AAK20919) (lafA) lateral flagellin LafA [ND (AI143)] [Aeromonas hydrophila str. AH-3]
gene1436 VFG038882(gb|YP_001140303) (maf-5) modification accessory factor [Lateral flagella (VF0474)] [Aeromonas salmonicida subsp. salmonicida A449]
gene1437 VFG038881(gb|YP_001140302) (lfgL) lateral flagellar hook-associated protein, LfgL [Lateral flagella (VF0474)] [Aeromonas salmonicida subsp. salmonicida A449]
gene1438 VFG038880(gb|YP_001140301) (lfgK) lateral flagellar hook-associated protein [Lateral flagella (VF0474)] [Aeromonas salmonicida subsp. salmonicida A449]
gene1439 VFG043191(gi:74101663) (flgJ) FlgJL [ND (AI143)] [Aeromonas hydrophila str. AH-3]
gene1440 VFG038878(gb|YP_001140299) (flgI) flagellar basal body P-ring protein [Lateral flagella (VF0474)] [Aeromonas salmonicida subsp. salmonicida A449]
gene1441 VFG038877(gb|YP_001140298) (lfgH) lateral flagellar L-ring protein, LfgH [Lateral flagella (VF0474)] [Aeromonas salmonicida subsp. salmonicida A449]
gene1442 VFG043188(gi:74101660) (flgG) FlgGL [ND (AI143)] [Aeromonas hydrophila str. AH-3]
gene1443 VFG043187(gi:74101659) (flgF) FlgFL [ND (AI143)] [Aeromonas hydrophila str. AH-3]
gene1444 VFG043186(gi:74101658) (flgE) FlgEL [ND (AI143)] [Aeromonas hydrophila str. AH-3]
gene1445 VFG043185(gi:74101657) (flgD) FlgDL [ND (AI143)] [Aeromonas hydrophila str. AH-3]
gene1446 VFG043184(gi:74101656) (flgC) FlgCL [ND (AI143)] [Aeromonas hydrophila str. AH-3]
gene1447 VFG043183(gi:74101655) (flgB) FlgBL [ND (AI143)] [Aeromonas hydrophila str. AH-3]
gene1448 VFG043182(gi:74101654) (flgA) FlgAL [ND (AI143)] [Aeromonas hydrophila str. AH-3]
gene1449 VFG038870(gb|YP_001140291) (lfgM) lateral flagella anti-sigma-28 factor, LfgM [Lateral flagella (VF0474)] [Aeromonas salmonicida subsp. salmonicida A449]
gene1450 VFG043180(gi:74101652) (flgN) FlgNL [ND (AI143)] [Aeromonas hydrophila str. AH-3]
gene1451 VFG043179(gi:74101651) (fliJ) FliJL [ND (AI143)] [Aeromonas hydrophila str. AH-3]
gene1452 VFG043178(gi:74101650) (fliI) FliIL [ND (AI143)] [Aeromonas hydrophila str. AH-3]
gene1453 VFG043177(gi:74101649) (fliH) FliHL [ND (AI143)] [Aeromonas hydrophila str. AH-3]
gene1454 VFG043176(gi:74101648) (fliG) FliGL [ND (AI143)] [Aeromonas hydrophila str. AH-3]
gene1455 VFG038864(gb|YP_001140285) (fliF) flagellar MS-ring protein [Lateral flagella (VF0474)] [Aeromonas salmonicida subsp. salmonicida A449]
gene1456 VFG043174(gi:74101646) (fliE) FliEL [ND (AI143)] [Aeromonas hydrophila str. AH-3]
gene1457 VFG038862(gb|YP_001140283) (lafK) two-component system lateral flagellar response regulator [Lateral flagella (VF0474)] [Aeromonas salmonicida subsp. salmonicida A449]
gene1458 VFG043172(gi:74101644) (flhA) FlhAL [ND (AI143)] [Aeromonas hydrophila str. AH-3]
gene1459 VFG043171(gi:74101643) (flhB) FlhBL [ND (AI143)] [Aeromonas hydrophila str. AH-3]
gene1460 VFG038859(gb|YP_001140280) (lfiR) lateral flagellar biosynthetic protein LfiR [Lateral flagella (VF0474)] [Aeromonas salmonicida subsp. salmonicida A449]
gene1461 VFG038858(gb|YP_001140279) (lfiQ) lateral flagellar biosynthetic protein, LfiQ [Lateral flagella (VF0474)] [Aeromonas salmonicida subsp. salmonicida A449]
gene1462 VFG038857(gb|YP_001140278) (fliP) flagellar biosynthesis protein FliP [Lateral flagella (VF0474)] [Aeromonas salmonicida subsp. salmonicida A449]
gene1463 VFG043167(gi:74101639) (fliN) FliNL [ND (AI143)] [Aeromonas hydrophila str. AH-3]
gene1464 VFG043166(gi:74101638) (fliM) FliML [ND (AI143)] [Aeromonas hydrophila str. AH-3]
gene1561 VFG038733(gi:330829152) (flaA) flagellin-like protein [Polar flagella (CVF786)] [Aeromonas veronii B565]
gene1562 VFG038730(gb|YP_856234) (flaA) flagellin [ND (AI144)] [Aeromonas hydrophila subsp. hydrophila ATCC 7966]
gene1564 VFG038731(gi:507521385) (flaA) flagellin [Polar flagella (VF0473)] [Aeromonas hydrophila ML09-119]
gene1570 VFG038851(gi:507521397) (nueB) flagellar-related pseudaminic acid synthase [Polar flagella (VF0473)] [Aeromonas hydrophila ML09-119]
gene1571 VFG038848(gi:507521398) (flmD) flagellar-related pseudaminic acid biosynthesis-associated protein [Polar flagella (VF0473)] [Aeromonas hydrophila ML09-119]
gene1631 VFG038504(gb|YP_856293) (tapF) type IV pilus biogenesis/stability protein, pilW-like [Tap type IV pili (CVF783)] [Aeromonas hydrophila subsp. hydrophila ATCC 7966]
gene1654 VFG038833(gi:145298724) (pomB2) flagellar motor protein MotB [Polar flagella (CVF786)] [Aeromonas salmonicida subsp. salmonicida A449]
gene1989 VFG044250(gi:145300223) (hutD) ABC-type hemin transporter, ATP-binding protein [direct heme uptake system (IA062)] [Aeromonas salmonicida subsp. salmonicida A449]
gene1990 VFG044249(gi:145300222) (hutC) ABC-type hemin transporter, permease protein [direct heme uptake system (IA062)] [Aeromonas salmonicida subsp. salmonicida A449]
gene1991 VFG044248(gi:145300221) (hutB) ABC-type hemin transporter, periplasmic component [direct heme uptake system (IA062)] [Aeromonas salmonicida subsp. salmonicida A449]
gene1992 VFG044247(gi:145300220) (hutX) heme iron utilization protein [direct heme uptake system (IA062)] [Aeromonas salmonicida subsp. salmonicida A449]
gene1993 VFG044246(gi:145300219) (hutZ) heme iron utilization protein [direct heme uptake system (IA062)] [Aeromonas salmonicida subsp. salmonicida A449]
gene1994 VFG044245(gi:145300218) (ASA_3331) hypothetical protein [direct heme uptake system (IA062)] [Aeromonas salmonicida subsp. salmonicida A449]
gene1995 VFG044244(gi:145300217) (ASA_3330) isochorismatase family protein [direct heme uptake system (IA062)] [Aeromonas salmonicida subsp. salmonicida A449]
gene1996 VFG044243(gi:145300216) (ASA_3329) iron-regulated protein [direct heme uptake system (IA062)] [Aeromonas salmonicida subsp. salmonicida A449]
gene1997 VFG044242(gi:145300215) (hutA) outer-membrane heme receptor [direct heme uptake system (IA062)] [Aeromonas salmonicida subsp. salmonicida A449]
gene2088 VFG038370(gi:507521520) (hcp) HcpA-like protein [T6SS (VF0480)] [Aeromonas hydrophila ML09-119]
gene2099 VFG038377(gi:145297534) (ASA_0454) lipoprotein [T6SS (CVF782)] [Aeromonas salmonicida subsp. salmonicida A449]
gene2102 VFG038355(gb|YP_001144305) (ascU) Type III secretion system inner membrane export apparatus protein AscU [T3SS (VF0479)] [Aeromonas salmonicida subsp. salmonicida A449]
gene2103 VFG042259(gi:46398250) (ascT) AscT [T3SS (SS032)] [Aeromonas hydrophila str. AH3]
gene2104 VFG042260(gi:46398251) (ascS) AscS [T3SS (SS032)] [Aeromonas hydrophila str. AH3]
gene2105 VFG038352(gb|YP_001144302) (ascR) Type III secretion system inner membrane export apparatus protein AscR [T3SS (VF0479)] [Aeromonas salmonicida subsp. salmonicida A449]
gene2106 VFG038351(gb|YP_001144301) (ascQ) type III secretion system protein AscQ [T3SS (VF0479)] [Aeromonas salmonicida subsp. salmonicida A449]
gene2108 VFG038349(gb|YP_001144299) (ascO) Type III secretion system protein AscO [T3SS (VF0479)] [Aeromonas salmonicida subsp. salmonicida A449]
gene2109 VFG042265(gi:46398256) (ascN) AscN [T3SS (SS032)] [Aeromonas hydrophila str. AH3]
gene2110 VFG038347(gb|YP_001144297) (aopN) AopN, secretion control of translocators and immune suppressor [T3SS (VF0479)] [Aeromonas salmonicida subsp. salmonicida A449]
gene2111 VFG038346(gb|YP_001144296) (acr1) Type III secretion system gatekeeper subunit  [T3SS (VF0479)] [Aeromonas salmonicida subsp. salmonicida A449]
gene2112 VFG042268(gi:46398259) (acr2) Acr2 [T3SS (SS032)] [Aeromonas hydrophila str. AH3]
gene2113 VFG042269(gi:46398260) (ascX) AscX [T3SS (SS032)] [Aeromonas hydrophila str. AH3]
gene2114 VFG038343(gb|YP_001144293) (ascY) chaperone protein [T3SS (VF0479)] [Aeromonas salmonicida subsp. salmonicida A449]
gene2115 VFG038342(gb|YP_001144292) (ascV) Type III secretion system inner membrane export apparatus protein AscV [T3SS (VF0479)] [Aeromonas salmonicida subsp. salmonicida A449]
gene2121 VFG042278(gi:46398269) (exsC) ExsC [T3SS (SS032)] [Aeromonas hydrophila str. AH3]
gene2124 VFG038332(gb|YP_001144282) (exsA) Type III secretion system transcriptional regulator [T3SS (VF0479)] [Aeromonas salmonicida subsp. salmonicida A449]
gene2126 VFG038330(gb|YP_001144280) (ascB) chaperone protein [T3SS (VF0479)] [Aeromonas salmonicida subsp. salmonicida A449]
gene2127 VFG038329(gb|YP_001144279) (ascC) Type III secretion system OM ring protein AscC [T3SS (VF0479)] [Aeromonas salmonicida subsp. salmonicida A449]
gene2128 VFG042284(gi:46398275) (ascD) AscD [T3SS (SS032)] [Aeromonas hydrophila str. AH3]
gene2129 VFG042285(gi:46398276) (ascE) AscE [T3SS (SS032)] [Aeromonas hydrophila str. AH3]
gene2130 VFG038326(gb|YP_001144276) (ascF) Type III secretion system needle complex subunit AscF [T3SS (VF0479)] [Aeromonas salmonicida subsp. salmonicida A449]
gene2131 VFG042287(gi:46398278) (ascG) AscG [T3SS (SS032)] [Aeromonas hydrophila str. AH3]
gene2133 VFG038323(gb|YP_001144273) (ascI) Type III secretion system inner rod protein AscI [T3SS (VF0479)] [Aeromonas salmonicida subsp. salmonicida A449]
gene2134 VFG042290(gi:46398281) (ascJ) AscJ [T3SS (SS032)] [Aeromonas hydrophila str. AH3]
gene2135 VFG042291(gi:46398282) (ascK) AscK [T3SS (SS032)] [Aeromonas hydrophila str. AH3]
gene2136 VFG042292(gi:46398283) (ascL) AscL [T3SS (SS032)] [Aeromonas hydrophila str. AH3]
gene2167 VFG038752(gb|YP_857151) (motY) sodium-type flagellar protein MotY [Polar flagella (CVF786)] [Aeromonas hydrophila subsp. hydrophila ATCC 7966]
gene2323 VFG013517(gi:113460873) (mrsA/glmM) phosphoglucosamine mutase [Exopolysaccharide (CVF495)] [Haemophilus somnus 129PT]
gene2330 VFG038831(gb|YP_857806) (pomB2) flagellar motor protein MotB [Polar flagella (CVF786)] [Aeromonas hydrophila subsp. hydrophila ATCC 7966]
gene2331 VFG038835(gb|YP_857807) (pomA2) chemotaxis protein PomA [Polar flagella (CVF786)] [Aeromonas hydrophila subsp. hydrophila ATCC 7966]
gene2522 VFG044235(gb|YP_856993) (amoA) isochorismate synthases [amonabactin (IA020)] [Aeromonas hydrophila subsp. hydrophila ATCC 7966]
gene2610 VFG046467 (FN3523_1640) translation elongation factor Tu [EF-Tu (CVF827)] [Francisella cf. tularensis subsp. novicida 3523]
gene2644 VFG049190 (KOX_00005) protein disaggregation chaperone [T6SS-II (CVF861)] [Klebsiella oxytoca KCTC 1686]
gene3142 VFG038496(gb|YP_858148) (tppF) type IV pilus pseudopilin [Tap type IV pili (CVF783)] [Aeromonas hydrophila subsp. hydrophila ATCC 7966]
gene3154 VFG042801(gi:145300516) (tapZ) type IV pilus assembly TapZ [Tap pili (AI103)] [Aeromonas salmonicida subsp. salmonicida A449]
gene3170 VFG038467(gb|YP_858122) (tapU) twitching ATPase [Tap type IV pili (CVF783)] [Aeromonas hydrophila subsp. hydrophila ATCC 7966]
gene3171 VFG038463(gb|YP_858121) (tapT) twitching ATPase [Tap type IV pili (CVF783)] [Aeromonas hydrophila subsp. hydrophila ATCC 7966]
gene3359 VFG038367(gb|YP_855660) (vgrG1) Type VI secretion system effector VgrG1, ADP-ribosyltransferase  [VgrG1 (TX001)] [Aeromonas hydrophila subsp. hydrophila ATCC 7966]
gene3360 VFG038407(gb|YP_856382) (vgrG) VgrG protein [T6SS (SS194)] [Aeromonas hydrophila subsp. hydrophila ATCC 7966]
gene3361 VFG038405(gi:117619593) (AHA_1847) PAAR motif-containing protein [T6SS (SS194)] [Aeromonas hydrophila subsp. hydrophila ATCC 7966]
gene3362 VFG038370(gi:507521520) (hcp) HcpA-like protein [T6SS (VF0480)] [Aeromonas hydrophila ML09-119]
gene3365 VFG038377(gi:145297534) (ASA_0454) lipoprotein [T6SS (CVF782)] [Aeromonas salmonicida subsp. salmonicida A449]
gene3370 VFG038367(gb|YP_855660) (vgrG1) Type VI secretion system effector VgrG1, ADP-ribosyltransferase  [VgrG1 (TX001)] [Aeromonas hydrophila subsp. hydrophila ATCC 7966]
gene3384 VFG038471(gb|YP_857247) (tapW) twitching ATPase [Tap type IV pili (CVF783)] [Aeromonas hydrophila subsp. hydrophila ATCC 7966]
gene3446 VFG038500(gb|YP_857189) (tapV) type IV pilus assembly protein TapV [Tap type IV pili (CVF783)] [Aeromonas hydrophila subsp. hydrophila ATCC 7966]
gene3684 VFG000477(gi:16766230) (rpoS) sigma S (sigma 38) factor of RNA polymerase, major sigmafactor during stationary phase [RpoS (VF0112)] [Salmonella enterica subsp. enterica serovar Typhimurium str. LT2]
gene3710 VFG038895(gb|YP_855347) (ast) thermostable cytotonic enterotoxin [Heat-stable cytotonic enterotoxin, Ast (CVF789)] [Aeromonas hydrophila subsp. hydrophila ATCC 7966]
gene3736 VFG013612(gi:113461676) (hemE) uroporphyrinogen decarboxylase [Heme biosynthesis (CVF506)] [Haemophilus somnus 129PT]
gene3805 VFG013288(gi:148825365) (galE) UDP-glucose 4-epimerase [LOS (CVF494)] [Haemophilus influenzae PittEE]
gene3812 VFG015388(gi:28870056) (ppkA) ppkA-related protein [Hcp secretion island-1 encoded type VI secretion system (H-T6SS) (CVF535)] [Pseudomonas syringae pv. tomato str. DC3000]
gene3849 VFG038370(gi:507521520) (hcp) HcpA-like protein [T6SS (VF0480)] [Aeromonas hydrophila ML09-119]
gene3850 VFG038405(gi:117619593) (AHA_1847) PAAR motif-containing protein [T6SS (SS194)] [Aeromonas hydrophila subsp. hydrophila ATCC 7966]
gene3852 VFG038370(gi:507521520) (hcp) HcpA-like protein [T6SS (VF0480)] [Aeromonas hydrophila ML09-119]
gene3853 VFG038371(gb|YP_856361) (vgrG) VgrG protein [T6SS (SS194)] [Aeromonas hydrophila subsp. hydrophila ATCC 7966]
gene3854 VFG038373(gb|YP_856362) (AHA_1828) Type VI secretion system protein [T6SS (SS194)] [Aeromonas hydrophila subsp. hydrophila ATCC 7966]
gene3855 VFG038374(gb|YP_856363) (AHA_1829) Type VI secretion system protein [T6SS (SS194)] [Aeromonas hydrophila subsp. hydrophila ATCC 7966]
gene3857 VFG038376(gb|YP_856365) (AHA_1831) Type VI secretion system protein [T6SS (SS194)] [Aeromonas hydrophila subsp. hydrophila ATCC 7966]
gene3858 VFG038378(gb|YP_856366) (AHA_1832) Type VI secretion system contractile sheath small subunit TssB/VipA [T6SS (SS194)] [Aeromonas hydrophila subsp. hydrophila ATCC 7966]
gene3859 VFG038380(gb|YP_856367) (AHA_1833) Type VI secretion system contractile sheath large subunit TssC/VipB [T6SS (SS194)] [Aeromonas hydrophila subsp. hydrophila ATCC 7966]
gene3860 VFG038381(gb|YP_856368) (AHA_1834) Type VI secretion system protein [T6SS (SS194)] [Aeromonas hydrophila subsp. hydrophila ATCC 7966]
gene3861 VFG038383(gb|YP_856369) (AHA_1835) Type VI secretion system protein [T6SS (SS194)] [Aeromonas hydrophila subsp. hydrophila ATCC 7966]
gene3862 VFG038385(gb|YP_856370) (AHA_1836) Type VI secretion system protein [T6SS (SS194)] [Aeromonas hydrophila subsp. hydrophila ATCC 7966]
gene3863 VFG038387(gb|YP_856371) (AHA_1837) Type VI secretion system protein [T6SS (SS194)] [Aeromonas hydrophila subsp. hydrophila ATCC 7966]
gene3864 VFG038389(gb|YP_856372) (AHA_1838) Type VI secretion system protein [T6SS (SS194)] [Aeromonas hydrophila subsp. hydrophila ATCC 7966]
gene3865 VFG038391(gb|YP_856373) (AHA_1839) Type VI secretion system protein [T6SS (SS194)] [Aeromonas hydrophila subsp. hydrophila ATCC 7966]
gene3866 VFG038394(gi:145299408) (ASA_2462) hypothetical protein [T6SS (CVF782)] [Aeromonas salmonicida subsp. salmonicida A449]
gene3867 VFG038395(gb|YP_856375) (clpB) type VI secretion system ATPase ClpV1 [T6SS (SS194)] [Aeromonas hydrophila subsp. hydrophila ATCC 7966]
gene3868 VFG038397(gb|YP_856376) (vasH/clpV) sigma-54 dependent transcriptional regulator [T6SS (SS194)] [Aeromonas hydrophila subsp. hydrophila ATCC 7966]
gene3869 VFG038399(gb|YP_856377) (AHA_1843) Type VI secretion system protein [T6SS (SS194)] [Aeromonas hydrophila subsp. hydrophila ATCC 7966]
gene3870 VFG038401(gb|YP_856378) (AHA_1844) Type VI secretion system protein [T6SS (SS194)] [Aeromonas hydrophila subsp. hydrophila ATCC 7966]
gene3871 VFG038402(gb|YP_856379) (vasK/icmF) Type VI secretion system protein [T6SS (SS194)] [Aeromonas hydrophila subsp. hydrophila ATCC 7966]
gene3872 VFG038403(gb|YP_856380) (AHA_1846) Type VI secretion system protein [T6SS (SS194)] [Aeromonas hydrophila subsp. hydrophila ATCC 7966]
gene3873 VFG038405(gi:117619593) (AHA_1847) PAAR motif-containing protein [T6SS (SS194)] [Aeromonas hydrophila subsp. hydrophila ATCC 7966]
gene3874 VFG038368(gi:507520712) (vgrG1) Rhs element Vgr protein [T6SS (VF0480)] [Aeromonas hydrophila ML09-119]
gene3875 VFG038407(gb|YP_856382) (vgrG) VgrG protein [T6SS (SS194)] [Aeromonas hydrophila subsp. hydrophila ATCC 7966]
gene3949 VFG042293(gi:111143381) (aexU) AexT-like protein [T3SS (SS032)] [Aeromonas hydrophila str. SSU]
gene3985 VFG013197(gi:170717931) (hemB) Porphobilinogen synthase [Heme biosynthesis (CVF506)] [Haemophilus somnus 2336]
gene4032 VFG038840(gi:507521851) (flmH) flagellar-related 3-oxoacyl-ACP reductase [Polar flagella (VF0473)] [Aeromonas hydrophila ML09-119]
gene4161 VFG038905(gi:507523204) (AHML_18530) hemolysin [Hemolysin III (CVF793)] [Aeromonas hydrophila ML09-119]
gene4206 VFG013532(gi:148826097) (pgi) glucose-6-phosphate isomerase [Exopolysaccharide (CVF495)] [Haemophilus influenzae PittEE]
gene4350 VFG038370(gi:507521520) (hcp) HcpA-like protein [T6SS (VF0480)] [Aeromonas hydrophila ML09-119]
gene4378 VFG010484(gi:54296712) (htpB) 60 kDa chaperonin (Protein Cpn60)(groEL protein)(Heat shock protein B). [Hsp60 (CVF347)] [Legionella pneumophila str. Paris]
gene4398 VFG001862(gb|YP_096397) (katB) catalase-peroxidase KatB [KatAB (VF0168)] [Legionella pneumophila subsp. pneumophila str. Philadelphia 1]
gene4425 VFG046467 (FN3523_1640) translation elongation factor Tu [EF-Tu (CVF827)] [Francisella cf. tularensis subsp. novicida 3523]
gene4524 VFG016491(gi:26553484) (tuf) elongation factor Tu [EF-Tu (CVF587)] [Mycoplasma penetrans HF-2]
Table S4. Genome annotation by VFDB(A03)

Score

Query-Name

Hit-Name

Description

1120

gene112

VFG038841(gi:145297258)

(flmH) 3-oxoacyl-ACP reductase [Polar flagella (CVF786)] [Aeromonas salmonicida subsp. salmonicida A449]

582

gene114

VFG038843(gi:145297256)

(flmH) flagellar modification protein FlmH [Polar flagella (CVF786)] [Aeromonas salmonicida subsp. salmonicida A449]

1105

gene115

VFG038844(gb|YP_858601)

(nueA) NeuA protein [Polar flagella (CVF786)] [Aeromonas hydrophila subsp. hydrophila ATCC 7966]

1758

gene116

VFG038847(gb|YP_858602)

(flmD) FlmD protein [Polar flagella (CVF786)] [Aeromonas hydrophila subsp. hydrophila ATCC 7966]

1742

gene117

VFG038850(gb|YP_858603)

(nueB) pseudaminic acid synthase, NeuB [Polar flagella (CVF786)] [Aeromonas hydrophila subsp. hydrophila ATCC 7966]

2720

gene120

VFG038750(gb|YP_856239)

(maf-1) putative flagellin glycosyltransferase [ND (AI144)] [Aeromonas hydrophila subsp. hydrophila ATCC 7966]

677

gene121

VFG038748(gi:145299586)

(flaJ) flagellar protein FliS [Polar flagella (CVF786)] [Aeromonas salmonicida subsp. salmonicida A449]

2220

gene122

VFG038742(gb|YP_856237)

(flaH) flagellar hook-associated protein 2 [ND (AI144)] [Aeromonas hydrophila subsp. hydrophila ATCC 7966]

577

gene123

VFG038741(gi:145299588)

(flaG) flagellar protein FlaG [Polar flagella (CVF786)] [Aeromonas salmonicida subsp. salmonicida A449]

1428

gene124

VFG038736(gi:145299589)

(flaB) flagellin B [Polar flagella (CVF786)] [Aeromonas salmonicida subsp. salmonicida A449]

1356

gene125

VFG038732(gi:145299590)

(flaA) flagellin A [Polar flagella (CVF786)] [Aeromonas salmonicida subsp. salmonicida A449]

1964

gene199

VFG038474(gi:330829098)

(tapW) Tfp pilus assembly protein, ATPase PilU [Tap type IV pili (CVF783)] [Aeromonas veronii B565]

823

gene362

VFG013171(gi:170719013)

(gmhA/lpcA) phosphoheptose isomerase [LOS (CVF494)] [Haemophilus somnus 2336]

823

gene433

VFG043204(gb|YP_855930)

(cheW-2) chemotaxis protein CheW [ND (AI144)] [Aeromonas hydrophila subsp. hydrophila ATCC 7966]

1484

gene434

VFG038729(gi:330828824)

(cheW) CheW domain-containing protein [Polar flagella (CVF786)] [Aeromonas veronii B565]

1396

gene435

VFG038725(gi:330828823)

(B565_1123) CobQ/CobB/MinD/ParA family protein [Polar flagella (CVF786)] [Aeromonas veronii B565]

1562

gene436

VFG038721(gi:330828822)

(pomB) OmpA family protein [Polar flagella (CVF786)] [Aeromonas veronii B565]

1234

gene437

VFG038717(gi:330828821)

(pomA) MotA/TolQ/ExbB proton channel [Polar flagella (CVF786)] [Aeromonas veronii B565]

1925

gene438

VFG038713(gi:330828820)

(cheB-2) two component system response-regulator/protein-glutamate methylesterase CheB [Polar flagella (CVF786)] [Aeromonas veronii B565]

3719

gene439

VFG038709(gi:330828819)

(cheA-2) transducing histidine kinase [Polar flagella (CVF786)] [Aeromonas veronii B565]

1288

gene440

VFG038705(gi:330828818)

(cheZ) chemotaxis protein CheZ [Polar flagella (CVF786)] [Aeromonas veronii B565]

640

gene441

VFG038701(gi:330828817)

(cheY) response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Polar flagella (CVF786)] [Aeromonas veronii B565]

1155

gene442

VFG038696(gi:145298363)

(fliA) flagellar biosynthesis sigma factor [Polar flagella (CVF786)] [Aeromonas salmonicida subsp. salmonicida A449]

1543

gene443

VFG038693(gi:330828815)

(flhG) CobQ/CobB/MinD/ParA family protein [Polar flagella (CVF786)] [Aeromonas veronii B565]

2503

gene444

VFG038689(gi:330828814)

(flhF) flagellar biosynthesis protein FlhF [Polar flagella (CVF786)] [Aeromonas veronii B565]

3606

gene445

VFG038685(gi:330828813)

(flhA) flagellar biosynthesis protein FlhA [Polar flagella (CVF786)] [Aeromonas veronii B565]

1962

gene446

VFG038681(gi:330828812)

(flhB) flagellar biosynthetic protein FlhB [Polar flagella (CVF786)] [Aeromonas veronii B565]

1330

gene447

VFG038677(gi:330828811)

(fliR) flagellar biosynthetic protein fliR [Polar flagella (CVF786)] [Aeromonas veronii B565]

433

gene448

VFG038673(gi:330828810)

(fliQ) flagellar biosynthetic protein FliQ [Polar flagella (CVF786)] [Aeromonas veronii B565]

1140

gene449

VFG038669(gi:330828809)

(fliP) flagellar biosynthetic protein FliP [Polar flagella (CVF786)] [Aeromonas veronii B565]

617

gene450

VFG038665(gi:330828808)

(fliO) flagellar biosynthesis protein, FliO [Polar flagella (CVF786)] [Aeromonas veronii B565]

653

gene451

VFG038661(gi:330828807)

(fliN) flagellar motor switch phosphatase FliY [Polar flagella (CVF786)] [Aeromonas veronii B565]

1852

gene452

VFG038657(gi:330828806)

(fliM) flagellar motor switch protein FliM [Polar flagella (CVF786)] [Aeromonas veronii B565]

858

gene453

VFG038653(gi:330828805)

(fliL) flagellar basal body-associated protein FliL [Polar flagella (CVF786)] [Aeromonas veronii B565]

2715

gene454

VFG038649(gi:330828804)

(fliK) putative polar flagellar hook-length control protein FliK [Polar flagella (CVF786)] [Aeromonas veronii B565]

731

gene455

VFG038645(gi:330828803)

(fliJ) flagellar protein FliJ [Polar flagella (CVF786)] [Aeromonas veronii B565]

2288

gene456

VFG038641(gi:330828802)

(fliI) flagellar protein export ATPase FliI [Polar flagella (CVF786)] [Aeromonas veronii B565]

1388

gene457

VFG038637(gi:330828801)

(fliH) flagellar assembly protein FliH [Polar flagella (CVF786)] [Aeromonas veronii B565]

1823

gene458

VFG038633(gi:330828800)

(fliG) flagellar motor switch protein FliG [Polar flagella (CVF786)] [Aeromonas veronii B565]

2979

gene459

VFG038629(gi:330828799)

(fliF) flagellar M-ring protein FliF [Polar flagella (CVF786)] [Aeromonas veronii B565]

522

gene460

VFG038624(gi:145298345)

(fliE) flagellar hook-basal body protein [Polar flagella (CVF786)] [Aeromonas salmonicida subsp. salmonicida A449]

3666

gene583

VFG038503(gi:330829260)

(tapV) Motility protein FimV [Tap type IV pili (CVF783)] [Aeromonas veronii B565]

1244

gene606

VFG038845(gi:507522470)

(nueA) flagellar-related 3-deoxy-D-manno-octulosonate cytidylyltransferase [Polar flagella (VF0473)] [Aeromonas hydrophila ML09-119]

1444

gene664

VFG038754(gi:145299432)

(motY) sodium-type polar flagellum motor protein [Polar flagella (CVF786)] [Aeromonas salmonicida subsp. salmonicida A449]

2315

gene693

VFG038903(gi:330830274)

(hlyA) putative transporter [Hemolysin HlyA (CVF792)] [Aeromonas veronii B565]

2336

gene708

VFG038758(gi:330830288)

(flrC) Fis family two component sigma54 specific transcriptional regulator [Polar flagella (CVF786)] [Aeromonas veronii B565]

1792

gene709

VFG038762(gi:330830289)

(flrB) two component system flagellar sensor histidine kinase FlrB [Polar flagella (CVF786)] [Aeromonas veronii B565]

2457

gene710

VFG038766(gi:330830290)

(flrA) FleQ protein [Polar flagella (CVF786)] [Aeromonas veronii B565]

2027

gene716

VFG038770(gi:330830296)

(flgL) flagellar hook-associated protein 3 [Polar flagella (CVF786)] [Aeromonas veronii B565]

3416

gene717

VFG038774(gi:330830297)

(flgK) flagellar hook-associated protein FlgK [Polar flagella (CVF786)] [Aeromonas veronii B565]

1888

gene718

VFG038778(gi:330830298)

(flgJ) peptidoglycan hydrolase FlgJ [Polar flagella (CVF786)] [Aeromonas veronii B565]

1864

gene719

VFG038782(gi:330830299)

(flgI) flagellar P-ring protein FlgI [Polar flagella (CVF786)] [Aeromonas veronii B565]

1143

gene720

VFG038786(gi:330830300)

(flgH) flagellar L-ring protein [Polar flagella (CVF786)] [Aeromonas veronii B565]

1359

gene721

VFG038790(gi:330830301)

(flgG) flagellar basal body rod protein FlgG [Polar flagella (CVF786)] [Aeromonas veronii B565]

1293

gene722

VFG038794(gi:330830302)

(flgF) flagellar basal-body rod protein FlgF [Polar flagella (CVF786)] [Aeromonas veronii B565]

1934

gene723

VFG038798(gi:330830303)

(flgE) flagellar hook protein FlgE [Polar flagella (CVF786)] [Aeromonas veronii B565]

1259

gene724

VFG038802(gi:330830304)

(flgD) flagellar hook capping protein [Polar flagella (CVF786)] [Aeromonas veronii B565]

727

gene725

VFG038806(gi:330830305)

(flgC) flagellar basal-body rod protein FlgC [Polar flagella (CVF786)] [Aeromonas veronii B565]

699

gene726

VFG038810(gi:330830306)

(flgB) flagellar basal-body rod protein FlgB [Polar flagella (CVF786)] [Aeromonas veronii B565]

1452

gene727

VFG038814(gi:330830307)

(cheR-3) CheR methyltransferase [Polar flagella (CVF786)] [Aeromonas veronii B565]

1589

gene728

VFG038818(gi:330830308)

(cheV) chemotaxis protein methyltransferase CheV [Polar flagella (CVF786)] [Aeromonas veronii B565]

1174

gene729

VFG038822(gi:330830309)

(flgA) flagellar basal body P-ring biosynthesis protein FlgA [Polar flagella (CVF786)] [Aeromonas veronii B565]

525

gene730

VFG038826(gi:330830310)

(flgM) anti-sigma-D factor [Polar flagella (CVF786)] [Aeromonas veronii B565]

609

gene731

VFG038830(gi:330830311)

(flgN) flagellar biosynthetic protein FlgN [Polar flagella (CVF786)] [Aeromonas veronii B565]

631

gene785

VFG000478(gi:16764063)

(fur) transcriptional repressor of iron-responsive genes (Fur family) (ferric uptake regulator) [Fur (VF0113)] [Salmonella enterica subsp. enterica serovar Typhimurium str. LT2]

2360

gene849

VFG038511(gi:330830423)

(flpL) protein FlpL [Flp type IV pili (CVF784)] [Aeromonas veronii B565]

834

gene850

VFG038515(gi:330830424)

(flpK) protein FlpK [Flp type IV pili (CVF784)] [Aeromonas veronii B565]

745

gene851

VFG038519(gi:330830425)

(flpJ) protein FlpJ [Flp type IV pili (CVF784)] [Aeromonas veronii B565]

1268

gene852

VFG038523(gi:330830426)

(flpI) Flp pilus assembly protein TadD [Flp type IV pili (CVF784)] [Aeromonas veronii B565]

1470

gene853

VFG038527(gi:330830427)

(flpH) Flp pilus assembly protein TadC [Flp type IV pili (CVF784)] [Aeromonas veronii B565]

1469

gene854

VFG038531(gi:330830428)

(flpG) Flp pilus assembly protein TadB [Flp type IV pili (CVF784)] [Aeromonas veronii B565]

2231

gene855

VFG038535(gi:330830429)

(flpF) Flp pilus assembly protein, ATPase CpaF [Flp type IV pili (CVF784)] [Aeromonas veronii B565]

1905

gene856

VFG038539(gi:330830430)

(flpE) Flp pilus assembly protein FlpE [Flp type IV pili (CVF784)] [Aeromonas veronii B565]

897

gene857

VFG038543(gi:330830431)

(flpD) protein FlpD [Flp type IV pili (CVF784)] [Aeromonas veronii B565]

2416

gene858

VFG038547(gi:330830432)

(flpC) protein transporter, outer membrane secretin (secretin) family [Flp type IV pili (CVF784)] [Aeromonas veronii B565]

1507

gene859

VFG038551(gi:330830433)

(flpB) Flp pilus assembly protein CpaB [Flp type IV pili (CVF784)] [Aeromonas veronii B565]

613

gene860

VFG038555(gi:330830434)

(flpA) Leader peptidase PilD [Flp type IV pili (CVF784)] [Aeromonas veronii B565]

315

gene861

VFG038559(gi:330830435)

(flp1) Flp pilin [Flp type IV pili (CVF784)] [Aeromonas veronii B565]

1626

gene912

VFG048789

(A225_3877) UDP-glucose dehydrogenase [Capsule (CVF854)] [Klebsiella oxytoca E718]

1328

gene913

VFG048986

(uge) uridine diphosphate galacturonate 4-epimerase [Capsule (CVF854)] [Klebsiella pneumoniae subsp. rhinoscleromatis SB3432]

706

gene933

VFG048800

(A225_3878) dTDP-4-dehydrorhamnose 3,5-epimerase [Capsule (CVF854)] [Klebsiella oxytoca E718]

1124

gene934

VFG005997(gi:24379858)

(rmlA) putative glucose-1-phosphate thymidyltransferase [Capsule (CVF186)] [Streptococcus mutans UA159]

1458

gene936

VFG007659(gi:59710773)

(rmlB) dTDP-glucose 4,6-dehydratase [Capsular polysaccharide (CVF282)] [Vibrio fischeri ES114]

3873

gene937

VFG049139

(acrB) acriflavine resistance protein B [AcrAB (CVF859)] [Klebsiella pneumoniae 342]

2753

gene1034

VFG038263(gi:330830587)

(exeA) general secretion pathway protein A [T2SS (CVF780)] [Aeromonas veronii B565]

1151

gene1035

VFG038267(gi:330830588)

(exeB) general secretion pathway protein B [T2SS (CVF780)] [Aeromonas veronii B565]

1431

gene1036

VFG038271(gi:330830589)

(exeC) general secretion pathway protein C [T2SS (CVF780)] [Aeromonas veronii B565]

3514

gene1037

VFG038275(gi:330830590)

(exeD) general secretion pathway protein D [T2SS (CVF780)] [Aeromonas veronii B565]

2599

gene1038

VFG038279(gi:330830591)

(exeE) type II secretory pathway, ATPase PulE-like protein [T2SS (CVF780)] [Aeromonas veronii B565]

2120

gene1039

VFG038283(gi:330830592)

(exeF) general secretion pathway protein F [T2SS (CVF780)] [Aeromonas veronii B565]

744

gene1040

VFG038287(gi:330830593)

(exeG) Pullulanase G protein [T2SS (CVF780)] [Aeromonas veronii B565]

935

gene1041

VFG038291(gi:330830594)

(exeH) general secretion pathway protein H [T2SS (CVF780)] [Aeromonas veronii B565]

612

gene1042

VFG038295(gi:330830595)

(exeI) general secretion pathway protein I [T2SS (CVF780)] [Aeromonas veronii B565]

1124

gene1043

VFG038299(gi:330830596)

(exeJ) general secretion pathway protein J [T2SS (CVF780)] [Aeromonas veronii B565]

1723

gene1044

VFG038303(gi:330830597)

(exeK) general secretion pathway protein K [T2SS (CVF780)] [Aeromonas veronii B565]

2004

gene1045

VFG038307(gi:330830598)

(exeL) general secretion pathway protein L [T2SS (CVF780)] [Aeromonas veronii B565]

815

gene1046

VFG038311(gi:330830599)

(exeM) general secretion pathway protein M [T2SS (CVF780)] [Aeromonas veronii B565]

1277

gene1047

VFG038315(gi:330830600)

(exeN) general secretion pathway protein N [T2SS (CVF780)] [Aeromonas veronii B565]

1213

gene1080

VFG013465(gb|NP_439706)

(kdsA) 2-dehydro-3-deoxyphosphooctonate aldolase [LOS (CVF494)] [Haemophilus influenzae Rd KW20]

3823

gene1116

VFG038462(gi:330828668)

(tapQ) type IV pilus secretin PilQ [Tap type IV pili (CVF783)] [Aeromonas veronii B565]

940

gene1117

VFG038458(gi:330828667)

(tapP) type IV pilus biogenesis protein PilP [Tap type IV pili (CVF783)] [Aeromonas veronii B565]

1063

gene1118

VFG038454(gi:330828666)

(tapO) type IV pilus biogenesis protein PilO [Tap type IV pili (CVF783)] [Aeromonas veronii B565]

986

gene1119

VFG038450(gi:330828665)

(tapN) type IV pilus biogenesis PilN [Tap type IV pili (CVF783)] [Aeromonas veronii B565]

1833

gene1120

VFG038446(gi:330828664)

(tapM) type IV pilus biogenesis protein PilM [Tap type IV pili (CVF783)] [Aeromonas veronii B565]

1163

gene1149

VFG038911(gi:330828638)

(B565_0938) Thermostable hemolysin [Thermostable hemolysin (TH) (CVF794)] [Aeromonas veronii B565]

3045

gene1243

VFG044242(gi:145300215)

(hutA) outer-membrane heme receptor [direct heme uptake system (IA062)] [Aeromonas salmonicida subsp. salmonicida A449]

1228

gene1244

VFG044243(gi:145300216)

(ASA_3329) iron-regulated protein [direct heme uptake system (IA062)] [Aeromonas salmonicida subsp. salmonicida A449]

697

gene1245

VFG044244(gi:145300217)

(ASA_3330) isochorismatase family protein [direct heme uptake system (IA062)] [Aeromonas salmonicida subsp. salmonicida A449]

919

gene1247

VFG044246(gi:145300219)

(hutZ) heme iron utilization protein [direct heme uptake system (IA062)] [Aeromonas salmonicida subsp. salmonicida A449]

789

gene1248

VFG044247(gi:145300220)

(hutX) heme iron utilization protein [direct heme uptake system (IA062)] [Aeromonas salmonicida subsp. salmonicida A449]

1063

gene1249

VFG044248(gi:145300221)

(hutB) ABC-type hemin transporter, periplasmic component [direct heme uptake system (IA062)] [Aeromonas salmonicida subsp. salmonicida A449]

1165

gene1250

VFG044249(gi:145300222)

(hutC) ABC-type hemin transporter, permease protein [direct heme uptake system (IA062)] [Aeromonas salmonicida subsp. salmonicida A449]

1135

gene1251

VFG044250(gi:145300223)

(hutD) ABC-type hemin transporter, ATP-binding protein [direct heme uptake system (IA062)] [Aeromonas salmonicida subsp. salmonicida A449]

1811

gene1371

VFG038466(gi:330831213)

(tapT) Pilus retraction ATPase PilT [Tap type IV pili (CVF783)] [Aeromonas veronii B565]

1947

gene1372

VFG038470(gi:330831212)

(tapU) Twitching motility protein PilU [Tap type IV pili (CVF783)] [Aeromonas veronii B565]

1072

gene1388

VFG038621(gi:330831196)

(motX) sodium-type flagellar motor component [Polar flagella (CVF786)] [Aeromonas veronii B565]

681

gene1415

VFG038478(gi:330831169)

(tppA) TppA protein [Tap type IV pili (CVF783)] [Aeromonas veronii B565]

963

gene1416

VFG038482(gi:330831168)

(tppB) type IV pilus assembly protein [Tap type IV pili (CVF783)] [Aeromonas veronii B565]

1474

gene1417

VFG038484(gi:330831167)

(tppC) TppC protein [Tap type IV pili (CVF783)] [Aeromonas veronii B565]

640

gene1418

VFG038486(gi:330831166)

(tppD) hypothetical protein [Tap type IV pili (CVF783)] [Aeromonas veronii B565]

4639

gene1420

VFG038490(gi:330831165)

(tapY1) TapY1 protein [Tap type IV pili (CVF783)] [Aeromonas veronii B565]

478

gene1421

VFG038491(gi:330831164)

(tapY2) TapY2 protein [Tap type IV pili (CVF783)] [Aeromonas veronii B565]

780

gene1423

VFG038495(gi:330831162)

(tppE) putative type IV pilus biogenesis protein [Tap type IV pili (CVF783)] [Aeromonas veronii B565]

715

gene1427

VFG018241(gb|NP_230208)

(luxS) S-ribosylhomocysteinase [AI-2 (VF0406)] [Vibrio cholerae O1 biovar El Tor str. N16961]

3474

gene1440

VFG042801(gi:145300516)

(tapZ) type IV pilus assembly TapZ [Tap pili (AI103)] [Aeromonas salmonicida subsp. salmonicida A449]

2035

gene1509

VFG010484(gi:54296712)

(htpB) 60 kDa chaperonin (Protein Cpn60)(groEL protein)(Heat shock protein B). [Hsp60 (CVF347)] [Legionella pneumophila str. Paris]

1383

gene1559

VFG038616(gi:145300806)

(mshI) MSHA biogenesis protein MshI [Mannose-sensitive hemagglutinin (Msh) pilus, type IV pili (CVF785)] [Aeromonas salmonicida subsp. salmonicida A449]

1004

gene1560

VFG038613(gi:330831369)

(mshI1) MSHA biogenesis protein MshI1 [Mannose-sensitive hemagglutinin (Msh) pilus, type IV pili (CVF785)] [Aeromonas veronii B565]

1107

gene1561

VFG038609(gi:330831368)

(mshJ) MSHA biogenesis protein MshJ [Mannose-sensitive hemagglutinin (Msh) pilus, type IV pili (CVF785)] [Aeromonas veronii B565]

550

gene1562

VFG038605(gi:330831367)

(mshK) MSHA biogenesis protein MshK [Mannose-sensitive hemagglutinin (Msh) pilus, type IV pili (CVF785)] [Aeromonas veronii B565]

2519

gene1563

VFG038602(gi:330831366)

(mshL) MSHA biogenesis protein MshL [Mannose-sensitive hemagglutinin (Msh) pilus, type IV pili (CVF785)] [Aeromonas veronii B565]

1502

gene1564

VFG038598(gi:330831365)

(mshM) general secretion pathway protein A [Mannose-sensitive hemagglutinin (Msh) pilus, type IV pili (CVF785)] [Aeromonas veronii B565]

1817

gene1565

VFG038594(gi:330831364)

(mshN) hypothetical protein [Mannose-sensitive hemagglutinin (Msh) pilus, type IV pili (CVF785)] [Aeromonas veronii B565]

2969

gene1566

VFG038591(gi:330831363)

(mshE) type IV pilin [Mannose-sensitive hemagglutinin (Msh) pilus, type IV pili (CVF785)] [Aeromonas veronii B565]

2089

gene1567

VFG038588(gi:330831362)

(mshG) GspF family protein [Mannose-sensitive hemagglutinin (Msh) pilus, type IV pili (CVF785)] [Aeromonas veronii B565]

777

gene1568

VFG038585(gi:330831361)

(mshF) hypothetical protein [Mannose-sensitive hemagglutinin (Msh) pilus, type IV pili (CVF785)] [Aeromonas veronii B565]

1157

gene1569

VFG038582(gi:330831360)

(mshA) Msha pilin protein mshb [Mannose-sensitive hemagglutinin (Msh) pilus, type IV pili (CVF785)] [Aeromonas veronii B565]

633

gene1571

VFG038576(gi:507519910)

(mshC) MSHA pilin protein mshC [MSHA type IV pili (VF0477)] [Aeromonas hydrophila ML09-119]

950

gene1572

VFG038574(gi:330831357)

(mshD) MSHA biogenesis protein MshN/MshD [Mannose-sensitive hemagglutinin (Msh) pilus, type IV pili (CVF785)] [Aeromonas veronii B565]

1488

gene1573

VFG038569(gi:145300799)

(mshO) MSHA biogenesis protein MshO [Mannose-sensitive hemagglutinin (Msh) pilus, type IV pili (CVF785)] [Aeromonas salmonicida subsp. salmonicida A449]

693

gene1574

VFG038565(gi:145300798)

(mshP) MSHA biogenesis protein MshP [Mannose-sensitive hemagglutinin (Msh) pilus, type IV pili (CVF785)] [Aeromonas salmonicida subsp. salmonicida A449]

2526

gene1608

VFG038891(gb|YP_854967)

(aerA/act) Aerolysin A [aerolysin (TX450)] [Aeromonas hydrophila subsp. hydrophila ATCC 7966]

239

gene1663

VFG010907(gi:54296805)

(csrA) global regulator CsrA [Carbon storage regulator A (CVF362)] [Legionella pneumophila str. Paris]

1287

gene1986

VFG038838(gi:330830901)

(pomA2) chemotaxis protein PomA [Polar flagella (CVF786)] [Aeromonas veronii B565]

1469

gene1987

VFG038834(gi:330830900)

(pomB2) sodium-driven polar flagellar protein [Polar flagella (CVF786)] [Aeromonas veronii B565]

1615

gene1994

VFG013517(gi:113460873)

(mrsA/glmM) phosphoglucosamine mutase [Exopolysaccharide (CVF495)] [Haemophilus somnus 129PT]

1620

gene2005

VFG046474

(OOM_0626) elongation factor [EF-Tu (CVF827)] [Francisella noatunensis subsp. orientalis str. Toba 04]

1642

gene2022

VFG046474

(OOM_0626) elongation factor [EF-Tu (CVF827)] [Francisella noatunensis subsp. orientalis str. Toba 04]

3517

gene2056

VFG049190

(KOX_00005) protein disaggregation chaperone [T6SS-II (CVF861)] [Klebsiella oxytoca KCTC 1686]

1255

gene2306

VFG038507(gi:330830070)

(tapF) type IV pilus biogenesis/stability protein PilW [Tap type IV pili (CVF783)] [Aeromonas veronii B565]

1386

gene2338

VFG038833(gi:145298724)

(pomB2) flagellar motor protein MotB [Polar flagella (CVF786)] [Aeromonas salmonicida subsp. salmonicida A449]

1255

gene2511

VFG000477(gi:16766230)

(rpoS) sigma S (sigma 38) factor of RNA polymerase, major sigmafactor during stationary phase [RpoS (VF0112)] [Salmonella enterica subsp. enterica serovar Typhimurium str. LT2]

1278

gene2556

VFG013286(gb|NP_438515)

(galE) UDP-glucose 4-epimerase [LOS (CVF494)] [Haemophilus influenzae Rd KW20]

3007

gene2662

VFG038434(gi:330828059)

(tapB) type IV-A pilus assembly ATPase PilB [Tap type IV pili (CVF783)] [Aeromonas veronii B565]

2127

gene2663

VFG038438(gi:330828058)

(tapC) type IV pilus assembly protein tapC [Tap type IV pili (CVF783)] [Aeromonas veronii B565]

1355

gene2664

VFG038319(gi:330828057)

(tapD) N-methyltransferase [T2SS (CVF780)] [Aeromonas veronii B565]

1226

gene2747

VFG038840(gi:507521851)

(flmH) flagellar-related 3-oxoacyl-ACP reductase [Polar flagella (VF0473)] [Aeromonas hydrophila ML09-119]

2911

gene3034

VFG001862(gb|YP_096397)

(katB) catalase-peroxidase KatB [KatAB (VF0168)] [Legionella pneumophila subsp. pneumophila str. Philadelphia 1]

1414

gene3337

VFG013197(gi:170717931)

(hemB) Porphobilinogen synthase [Heme biosynthesis (CVF506)] [Haemophilus somnus 2336]

1521

gene3680

VFG013612(gi:113461676)

(hemE) uroporphyrinogen decarboxylase [Heme biosynthesis (CVF506)] [Haemophilus somnus 129PT]

1041

gene3714

VFG038907(gi:330828499)

(B565_0799) Hemolysin III [Hemolysin III (CVF793)] [Aeromonas veronii B565]

2267

gene3941

VFG013531(gi:68249838)

(pgi) glucose-6-phosphate isomerase [Exopolysaccharide (CVF495)] [Haemophilus influenzae 86-028NP]

Table S5. Genome annotation by VFDB(A04)

Score Query-Name Hit-Name Description
1110 gene45 VFG038908(gb|YP_857708) (AHA_3217) thermostable hemolysin [Thermostable hemolysin (TH) (CVF794)] [Aeromonas hydrophila subsp. hydrophila ATCC 7966]
1828 gene68 VFG038443(gb|YP_857685) (tapM) type IV pilus assembly protein PilM [Tap type IV pili (CVF783)] [Aeromonas hydrophila subsp. hydrophila ATCC 7966]
996 gene69 VFG038447(gb|YP_857684) (tapN) type IV pilus biogenesis protein PilN [Tap type IV pili (CVF783)] [Aeromonas hydrophila subsp. hydrophila ATCC 7966]
1050 gene70 VFG038451(gb|YP_857683) (tapO) type IV pilus biogenesis protein PilO [Tap type IV pili (CVF783)] [Aeromonas hydrophila subsp. hydrophila ATCC 7966]
928 gene71 VFG038455(gb|YP_857682) (tapP) type IV pilus biogenesis protein PilP [Tap type IV pili (CVF783)] [Aeromonas hydrophila subsp. hydrophila ATCC 7966]
3784 gene72 VFG038459(gb|YP_857681) (tapQ) type IV pilus secretin PilQ [Tap type IV pili (CVF783)] [Aeromonas hydrophila subsp. hydrophila ATCC 7966]
1215 gene109 VFG013465(gb|NP_439706) (kdsA) 2-dehydro-3-deoxyphosphooctonate aldolase [LOS (CVF494)] [Haemophilus influenzae Rd KW20]
1449 gene364 VFG007659(gi:59710773) (rmlB) dTDP-glucose 4,6-dehydratase [Capsular polysaccharide (CVF282)] [Vibrio fischeri ES114]
1106 gene366 VFG018664(gi:157151373) (rfbA-1) glucose-1-phosphate thymidylyltransferase [Capsule (CVF186)] [Streptococcus gordonii str. Challis substr. CH1]
695 gene419 VFG038827(gb|YP_857351) (flgN) flagellar protein FlgN [ND (AI144)] [Aeromonas hydrophila subsp. hydrophila ATCC 7966]
528 gene420 VFG038823(gb|YP_857350) (flgM) anti-sigma-D factor [ND (AI144)] [Aeromonas hydrophila subsp. hydrophila ATCC 7966]
1195 gene421 VFG038819(gb|YP_857349) (flgA) flagella basal body P-ring formation protein FlgA [ND (AI144)] [Aeromonas hydrophila subsp. hydrophila ATCC 7966]
1595 gene422 VFG038815(gb|YP_857348) (cheV) CheV [ND (AI144)] [Aeromonas hydrophila subsp. hydrophila ATCC 7966]
1447 gene423 VFG038811(gb|YP_857347) (cheR-3) chemotaxis protein CheR [ND (AI144)] [Aeromonas hydrophila subsp. hydrophila ATCC 7966]
695 gene424 VFG038807(gb|YP_857346) (flgB) flagellar basal-body rod protein FlgB [ND (AI144)] [Aeromonas hydrophila subsp. hydrophila ATCC 7966]
723 gene425 VFG038803(gb|YP_857345) (flgC) flagellar basal body rod protein FlgC [ND (AI144)] [Aeromonas hydrophila subsp. hydrophila ATCC 7966]
1218 gene426 VFG038799(gb|YP_857344) (flgD) flagellar hook capping protein [ND (AI144)] [Aeromonas hydrophila subsp. hydrophila ATCC 7966]
2080 gene427 VFG038796(gi:507522559) (flgE) flagellar hook protein FlgE [Polar flagella (VF0473)] [Aeromonas hydrophila ML09-119]
1301 gene429 VFG038791(gb|YP_857342) (flgF) flagellar basal-body rod protein FlgF [ND (AI144)] [Aeromonas hydrophila subsp. hydrophila ATCC 7966]
1360 gene430 VFG038787(gb|YP_857341) (flgG) flagellar basal body rod protein FlgG [ND (AI144)] [Aeromonas hydrophila subsp. hydrophila ATCC 7966]
1175 gene431 VFG038783(gb|YP_857340) (flgH) flagellar basal body L-ring protein [ND (AI144)] [Aeromonas hydrophila subsp. hydrophila ATCC 7966]
1885 gene432 VFG038779(gb|YP_857339) (flgI) flagellar basal body P-ring protein [ND (AI144)] [Aeromonas hydrophila subsp. hydrophila ATCC 7966]
1912 gene433 VFG038776(gi:507522554) (flgJ) flagellar rod assembly protein/muramidase FlgJ [Polar flagella (VF0473)] [Aeromonas hydrophila ML09-119]
3410 gene434 VFG038771(gb|YP_857337) (flgK) flagellar hook-associated protein FlgK [ND (AI144)] [Aeromonas hydrophila subsp. hydrophila ATCC 7966]
2008 gene435 VFG038768(gi:507522552) (flgL) flagellar hook-associated protein FlgL [Polar flagella (VF0473)] [Aeromonas hydrophila ML09-119]
2441 gene441 VFG038763(gb|YP_857330) (fleQ/flrC) FleQ protein [ND (AI144)] [Aeromonas hydrophila subsp. hydrophila ATCC 7966]
1793 gene442 VFG038759(gb|YP_857329) (fleS/flrB) two-component sensor kinase [ND (AI144)] [Aeromonas hydrophila subsp. hydrophila ATCC 7966]
2346 gene443 VFG038755(gb|YP_857328) (fleR/flrC) transcriptional activator [ND (AI144)] [Aeromonas hydrophila subsp. hydrophila ATCC 7966]
2316 gene458 VFG038900(gb|YP_857314) (hlyA) Hemolysin A [Hemolysin HlyA (CVF792)] [Aeromonas hydrophila subsp. hydrophila ATCC 7966]
1298 gene492 VFG038845(gi:507522470) (nueA) flagellar-related 3-deoxy-D-manno-octulosonate cytidylyltransferase [Polar flagella (VF0473)] [Aeromonas hydrophila ML09-119]
1477 gene542 VFG038615(gi:507519898) (mshI) MSHA biogenesis protein MshI [MSHA type IV pili (VF0477)] [Aeromonas hydrophila ML09-119]
995 gene543 VFG038610(gb|YP_854916) (mshI1) MSHA (mannose-sensitive hemagglutinin) pili biogenesis protein MshI1, bitopic inner membrane protein [Mannose-sensitive hemagglutinin (Msh) pilus, type IV pili (CVF785)] [Aeromonas hydrophila subsp. hydrophila ATCC 7966]
1116 gene544 VFG038606(gb|YP_854917) (mshJ) MSHA (mannose-sensitive hemagglutinin) pili biogenesis protein MshJ, bitopic inner membrane protein, GspM-like [Mannose-sensitive hemagglutinin (Msh) pilus, type IV pili (CVF785)] [Aeromonas hydrophila subsp. hydrophila ATCC 7966]
548 gene545 VFG038603(gb|YP_008041515) (mshK) MSHA (mannose-sensitive hemagglutinin) pili biogenesis protein MshK, periplasmic protein, GspC-like [MSHA type IV pili (VF0477)] [Aeromonas hydrophila ML09-119]
2922 gene546 VFG038599(gb|YP_854918) (mshL) MSHA (mannose-sensitive hemagglutinin) pili biogenesis protein MshL, outer membrane secretin, GspD-like [Mannose-sensitive hemagglutinin (Msh) pilus, type IV pili (CVF785)] [Aeromonas hydrophila subsp. hydrophila ATCC 7966]
1517 gene547 VFG038595(gb|YP_854919) (mshM) membrane protein with ATPase domain, GspA-like [Mannose-sensitive hemagglutinin (Msh) pilus, type IV pili (CVF785)] [Aeromonas hydrophila subsp. hydrophila ATCC 7966]
1808 gene548 VFG038593(gi:507519904) (mshN) hypothetical protein [MSHA type IV pili (VF0477)] [Aeromonas hydrophila ML09-119]
2972 gene549 VFG038589(gb|YP_854921) (mshE) ATPase protein MshE, GspE-like [Mannose-sensitive hemagglutinin (Msh) pilus, type IV pili (CVF785)] [Aeromonas hydrophila subsp. hydrophila ATCC 7966]
2102 gene550 VFG038586(gb|YP_854922) (mshG) MSHA (mannose-sensitive hemagglutinin) pili biogenesis protein MshG, GspF-like [Mannose-sensitive hemagglutinin (Msh) pilus, type IV pili (CVF785)] [Aeromonas hydrophila subsp. hydrophila ATCC 7966]
785 gene551 VFG038583(gi:117619824) (mshF) hypothetical protein [Mannose-sensitive hemagglutinin (Msh) pilus, type IV pili (CVF785)] [Aeromonas hydrophila subsp. hydrophila ATCC 7966]
1167 gene552 VFG038580(gb|YP_854924) (mshB) MSHA (mannose-sensitive hemagglutinin) pili minor prepilin protein MshB [Mannose-sensitive hemagglutinin (Msh) pilus, type IV pili (CVF785)] [Aeromonas hydrophila subsp. hydrophila ATCC 7966]
809 gene554 VFG038575(gb|YP_854925) (mshC) MSHA (mannose-sensitive hemagglutinin) pili minor prepilin protein MshC [Mannose-sensitive hemagglutinin (Msh) pilus, type IV pili (CVF785)] [Aeromonas hydrophila subsp. hydrophila ATCC 7966]
345 gene593 VFG038891(gb|YP_854967) (aerA/act) Aerolysin A [aerolysin (TX450)] [Aeromonas hydrophila subsp. hydrophila ATCC 7966]
292 gene594 VFG038892(gi:507519971) (aerA/act) aerolysin [Aerolysin (VF0481)] [Aeromonas hydrophila ML09-119]
637 gene595 VFG038892(gi:507519971) (aerA/act) aerolysin [Aerolysin (VF0481)] [Aeromonas hydrophila ML09-119]
630 gene680 VFG038409(gi:507520051) (fimA) fimbrial protein [Type I pili (VF0486)] [Aeromonas hydrophila ML09-119]
4518 gene682 VFG038412(gb|YP_855054) (fimC) outer membrane usher protein [Type I fimbriae (CVF796)] [Aeromonas hydrophila subsp. hydrophila ATCC 7966]
1280 gene683 VFG038417(gi:507520054) (fimD) fimbrial chaperone protein [Type I pili (VF0486)] [Aeromonas hydrophila ML09-119]
1781 gene684 VFG038423(gi:330828179) (fimE) type I pilus assembly protein FimE [Type I fimbriae (CVF796)] [Aeromonas veronii B565]
869 gene685 VFG038424(gb|YP_855057) (fimF) fimbrial protein [Type I fimbriae (CVF796)] [Aeromonas hydrophila subsp. hydrophila ATCC 7966]
1466 gene728 VFG038268(gb|YP_855101) (exeC) general secretion pathway protein C [exe (SS209)] [Aeromonas hydrophila subsp. hydrophila ATCC 7966]
3499 gene729 VFG038272(gb|YP_855102) (exeD) general secretion pathway protein D [exe (SS209)] [Aeromonas hydrophila subsp. hydrophila ATCC 7966]
2611 gene730 VFG038277(gi:507520101) (exeE) general secretory pathway protein E [Exe T2SS (VF0478)] [Aeromonas hydrophila ML09-119]
2135 gene731 VFG038280(gb|YP_855104) (exeF) general secretion pathway protein F [exe (SS209)] [Aeromonas hydrophila subsp. hydrophila ATCC 7966]
749 gene732 VFG038284(gb|YP_855105) (exeG) general secretion pathway protein G [exe (SS209)] [Aeromonas hydrophila subsp. hydrophila ATCC 7966]
919 gene733 VFG038289(gi:507520105) (exeH) general secretion pathway protein H [Exe T2SS (VF0478)] [Aeromonas hydrophila ML09-119]
622 gene734 VFG038293(gi:507520106) (exeI) general secretion pathway protein I [Exe T2SS (VF0478)] [Aeromonas hydrophila ML09-119]
1083 gene735 VFG038296(gb|YP_855108) (exeJ) general secretion pathway protein J [exe (SS209)] [Aeromonas hydrophila subsp. hydrophila ATCC 7966]
1668 gene736 VFG038300(gb|YP_855109) (exeK) general secretion pathway protein K [exe (SS209)] [Aeromonas hydrophila subsp. hydrophila ATCC 7966]
2006 gene737 VFG038304(gb|YP_855110) (exeL) general secretion pathway protein L [exe (SS209)] [Aeromonas hydrophila subsp. hydrophila ATCC 7966]
818 gene738 VFG038309(gi:507520110) (exeM) general secretion pathway protein M [Exe T2SS (VF0478)] [Aeromonas hydrophila ML09-119]
1272 gene739 VFG038312(gb|YP_855112) (exeN) general secretion pathway protein N [exe (SS209)] [Aeromonas hydrophila subsp. hydrophila ATCC 7966]
1553 gene822 VFG038618(gb|YP_855202) (motX) sodium-type flagellar motor component [Polar flagella (CVF786)] [Aeromonas hydrophila subsp. hydrophila ATCC 7966]
857 gene849 VFG038492(gb|YP_855228) (tppE) type IV pilus pseudopilin [Tap type IV pili (CVF783)] [Aeromonas hydrophila subsp. hydrophila ATCC 7966]
696 gene850 VFG038480(gi:507520223) (tppB) type IV pilus modification protein [Tap type IV pili (VF0475)] [Aeromonas hydrophila ML09-119]
5906 gene853 VFG038488(gi:507520226) (tapY) type IV pilus biogenesis protein [Tap type IV pili (VF0475)] [Aeromonas hydrophila ML09-119]
677 gene854 VFG038476(gi:507520227) (tppA) type IV pilus related protein [Tap type IV pili (VF0475)] [Aeromonas hydrophila ML09-119]
720 gene863 VFG018241(gb|NP_230208) (luxS) S-ribosylhomocysteinase [AI-2 (VF0406)] [Vibrio cholerae O1 biovar El Tor str. N16961]
541 gene954 VFG038622(gb|YP_855903) (fliE) flagellar hook-basal body complex protein FliE [ND (AI144)] [Aeromonas hydrophila subsp. hydrophila ATCC 7966]
2997 gene955 VFG038627(gi:507520997) (fliF) flagellar MS-ring protein [Polar flagella (VF0473)] [Aeromonas hydrophila ML09-119]
1824 gene956 VFG038630(gb|YP_855905) (fliG) flagellar motor switch protein G [ND (AI144)] [Aeromonas hydrophila subsp. hydrophila ATCC 7966]
1363 gene957 VFG038635(gi:507520999) (fliH) flagellar assembly protein FliH [Polar flagella (VF0473)] [Aeromonas hydrophila ML09-119]
2287 gene958 VFG038638(gb|YP_855907) (fliI) flagellum-specific ATP synthase [ND (AI144)] [Aeromonas hydrophila subsp. hydrophila ATCC 7966]
726 gene959 VFG038642(gb|YP_855908) (fliJ) flagellar export protein FliJ [ND (AI144)] [Aeromonas hydrophila subsp. hydrophila ATCC 7966]
2536 gene960 VFG038647(gi:507521002) (fliK) flagellar hook-length control protein FliK [Polar flagella (VF0473)] [Aeromonas hydrophila ML09-119]
887 gene961 VFG038650(gb|YP_855910) (fliL) flagellar basal body-associated protein FliL [ND (AI144)] [Aeromonas hydrophila subsp. hydrophila ATCC 7966]
1853 gene962 VFG038654(gb|YP_855911) (fliM) flagellar motor switch protein FliM [ND (AI144)] [Aeromonas hydrophila subsp. hydrophila ATCC 7966]
653 gene963 VFG038658(gb|YP_855912) (fliN) flagellar motor switch protein FliN [ND (AI144)] [Aeromonas hydrophila subsp. hydrophila ATCC 7966]
615 gene964 VFG038662(gb|YP_855913) (fliO) flagellar biosynthesis protein, FliO [ND (AI144)] [Aeromonas hydrophila subsp. hydrophila ATCC 7966]
1308 gene965 VFG038667(gi:507521007) (fliP) flagellar biosynthesis protein FliP [Polar flagella (VF0473)] [Aeromonas hydrophila ML09-119]
446 gene966 VFG038670(gb|YP_855915) (fliQ) flagellar biosynthetic protein FliQ [ND (AI144)] [Aeromonas hydrophila subsp. hydrophila ATCC 7966]
1318 gene967 VFG038674(gb|YP_855916) (fliR) flagellar biosynthesis protein FliR [ND (AI144)] [Aeromonas hydrophila subsp. hydrophila ATCC 7966]
1986 gene968 VFG038679(gi:507521010) (flhB) flagellar biosynthetic protein FlhB [Polar flagella (VF0473)] [Aeromonas hydrophila ML09-119]
3625 gene969 VFG038683(gi:507521011) (flhA) flagellar biosynthesis protein FlhA [Polar flagella (VF0473)] [Aeromonas hydrophila ML09-119]
2493 gene970 VFG038687(gi:507521012) (flhF) flagellar biosynthesis protein FlhF [Polar flagella (VF0473)] [Aeromonas hydrophila ML09-119]
1541 gene971 VFG038691(gi:507521013) (flhG) flagellar-related protein [Polar flagella (VF0473)] [Aeromonas hydrophila ML09-119]
1241 gene972 VFG038694(gb|YP_855921) (fliA) flagellar biosynthesis sigma factor [ND (AI144)] [Aeromonas hydrophila subsp. hydrophila ATCC 7966]
639 gene973 VFG038698(gb|YP_855922) (cheY) chemotaxis protein CheY [ND (AI144)] [Aeromonas hydrophila subsp. hydrophila ATCC 7966]
1284 gene974 VFG038702(gb|YP_855923) (cheZ) chemotaxis protein CheZ [ND (AI144)] [Aeromonas hydrophila subsp. hydrophila ATCC 7966]
3723 gene975 VFG038707(gi:507521017) (cheA) flagellar-related chemotaxis protein CheA [Polar flagella (VF0473)] [Aeromonas hydrophila ML09-119]
1929 gene976 VFG038710(gb|YP_855925) (cheB-2) chemotaxis-specific methylesterase [ND (AI144)] [Aeromonas hydrophila subsp. hydrophila ATCC 7966]
1251 gene977 VFG038714(gb|YP_855926) (motA) chemotaxis protein MotA [ND (AI144)] [Aeromonas hydrophila subsp. hydrophila ATCC 7966]
1588 gene978 VFG038719(gi:507521020) (pomB) flagellar-related chemotaxis protein [Polar flagella (VF0473)] [Aeromonas hydrophila ML09-119]
1406 gene979 VFG038722(gb|YP_855928) (AHA_1389) CobQ/CobB/MinD/ParA family protein [Polar flagella (CVF786)] [Aeromonas hydrophila subsp. hydrophila ATCC 7966]
1507 gene980 VFG038726(gb|YP_855929) (cheW) chemotaxis protein CheW [Polar flagella (CVF786)] [Aeromonas hydrophila subsp. hydrophila ATCC 7966]
823 gene981 VFG043204(gb|YP_855930) (cheW-2) chemotaxis protein CheW [ND (AI144)] [Aeromonas hydrophila subsp. hydrophila ATCC 7966]
3315 gene1101 VFG038898(gi:507521195) (ahh1) hemolysin [Extracellular hemolysin AHH1 (CVF791)] [Aeromonas hydrophila ML09-119]
621 gene1120 VFG000478(gi:16764063) (fur) transcriptional repressor of iron-responsive genes (Fur family) (ferric uptake regulator) [Fur (VF0113)] [Salmonella enterica subsp. enterica serovar Typhimurium str. LT2]
822 gene1163 VFG013171(gi:170719013) (gmhA/lpcA) phosphoheptose isomerase [LOS (CVF494)] [Haemophilus somnus 2336]
1262 gene1289 VFG038731(gi:507521385) (flaA) flagellin [Polar flagella (VF0473)] [Aeromonas hydrophila ML09-119]
1312 gene1290 VFG038731(gi:507521385) (flaA) flagellin [Polar flagella (VF0473)] [Aeromonas hydrophila ML09-119]
589 gene1291 VFG038740(gi:507521389) (flaG) flagellar protein FlaG [Polar flagella (VF0473)] [Aeromonas hydrophila ML09-119]
2317 gene1292 VFG038743(gi:507521390) (flaH) flagellar hook-associated protein FlaH [Polar flagella (VF0473)] [Aeromonas hydrophila ML09-119]
1661 gene1299 VFG038851(gi:507521397) (nueB) flagellar-related pseudaminic acid synthase [Polar flagella (VF0473)] [Aeromonas hydrophila ML09-119]
2582 gene1300 VFG038848(gi:507521398) (flmD) flagellar-related pseudaminic acid biosynthesis-associated protein [Polar flagella (VF0473)] [Aeromonas hydrophila ML09-119]
1354 gene1358 VFG038504(gb|YP_856293) (tapF) type IV pilus biogenesis/stability protein, pilW-like [Tap type IV pili (CVF783)] [Aeromonas hydrophila subsp. hydrophila ATCC 7966]
1419 gene1384 VFG038833(gi:145298724) (pomB2) flagellar motor protein MotB [Polar flagella (CVF786)] [Aeromonas salmonicida subsp. salmonicida A449]
2717 gene1484 VFG001862(gb|YP_096397) (katB) catalase-peroxidase KatB [KatAB (VF0168)] [Legionella pneumophila subsp. pneumophila str. Philadelphia 1]
1221 gene1593 VFG044250(gi:145300223) (hutD) ABC-type hemin transporter, ATP-binding protein [direct heme uptake system (IA062)] [Aeromonas salmonicida subsp. salmonicida A449]
1187 gene1594 VFG044249(gi:145300222) (hutC) ABC-type hemin transporter, permease protein [direct heme uptake system (IA062)] [Aeromonas salmonicida subsp. salmonicida A449]
1267 gene1595 VFG044248(gi:145300221) (hutB) ABC-type hemin transporter, periplasmic component [direct heme uptake system (IA062)] [Aeromonas salmonicida subsp. salmonicida A449]
869 gene1596 VFG044247(gi:145300220) (hutX) heme iron utilization protein [direct heme uptake system (IA062)] [Aeromonas salmonicida subsp. salmonicida A449]
946 gene1597 VFG044246(gi:145300219) (hutZ) heme iron utilization protein [direct heme uptake system (IA062)] [Aeromonas salmonicida subsp. salmonicida A449]
636 gene1598 VFG044245(gi:145300218) (ASA_3331) hypothetical protein [direct heme uptake system (IA062)] [Aeromonas salmonicida subsp. salmonicida A449]
830 gene1599 VFG044244(gi:145300217) (ASA_3330) isochorismatase family protein [direct heme uptake system (IA062)] [Aeromonas salmonicida subsp. salmonicida A449]
1324 gene1600 VFG044243(gi:145300216) (ASA_3329) iron-regulated protein [direct heme uptake system (IA062)] [Aeromonas salmonicida subsp. salmonicida A449]
3400 gene1601 VFG044242(gi:145300215) (hutA) outer-membrane heme receptor [direct heme uptake system (IA062)] [Aeromonas salmonicida subsp. salmonicida A449]
1265 gene1699 VFG013288(gi:148825365) (galE) UDP-glucose 4-epimerase [LOS (CVF494)] [Haemophilus influenzae PittEE]
2497 gene1706 VFG015388(gi:28870056) (ppkA) ppkA-related protein [Hcp secretion island-1 encoded type VI secretion system (H-T6SS) (CVF535)] [Pseudomonas syringae pv. tomato str. DC3000]
916 gene1743 VFG038370(gi:507521520) (hcp) HcpA-like protein [T6SS (VF0480)] [Aeromonas hydrophila ML09-119]
391 gene1744 VFG038405(gi:117619593) (AHA_1847) PAAR motif-containing protein [T6SS (SS194)] [Aeromonas hydrophila subsp. hydrophila ATCC 7966]
1295 gene1906 VFG038835(gb|YP_857807) (pomA2) chemotaxis protein PomA [Polar flagella (CVF786)] [Aeromonas hydrophila subsp. hydrophila ATCC 7966]
1571 gene1907 VFG038831(gb|YP_857806) (pomB2) flagellar motor protein MotB [Polar flagella (CVF786)] [Aeromonas hydrophila subsp. hydrophila ATCC 7966]
1592 gene1914 VFG013517(gi:113460873) (mrsA/glmM) phosphoglucosamine mutase [Exopolysaccharide (CVF495)] [Haemophilus somnus 129PT]
1521 gene2080 VFG038752(gb|YP_857151) (motY) sodium-type flagellar protein MotY [Polar flagella (CVF786)] [Aeromonas hydrophila subsp. hydrophila ATCC 7966]
923 gene2111 VFG042292(gi:46398283) (ascL) AscL [T3SS (SS032)] [Aeromonas hydrophila str. AH3]
732 gene2112 VFG042291(gi:46398282) (ascK) AscK [T3SS (SS032)] [Aeromonas hydrophila str. AH3]
1119 gene2113 VFG042290(gi:46398281) (ascJ) AscJ [T3SS (SS032)] [Aeromonas hydrophila str. AH3]
484 gene2114 VFG038323(gb|YP_001144273) (ascI) Type III secretion system inner rod protein AscI [T3SS (VF0479)] [Aeromonas salmonicida subsp. salmonicida A449]
459 gene2116 VFG042287(gi:46398278) (ascG) AscG [T3SS (SS032)] [Aeromonas hydrophila str. AH3]
311 gene2117 VFG038326(gb|YP_001144276) (ascF) Type III secretion system needle complex subunit AscF [T3SS (VF0479)] [Aeromonas salmonicida subsp. salmonicida A449]
261 gene2118 VFG042285(gi:46398276) (ascE) AscE [T3SS (SS032)] [Aeromonas hydrophila str. AH3]
1674 gene2119 VFG042284(gi:46398275) (ascD) AscD [T3SS (SS032)] [Aeromonas hydrophila str. AH3]
2947 gene2120 VFG038329(gb|YP_001144279) (ascC) Type III secretion system OM ring protein AscC [T3SS (VF0479)] [Aeromonas salmonicida subsp. salmonicida A449]
540 gene2121 VFG038330(gb|YP_001144280) (ascB) chaperone protein [T3SS (VF0479)] [Aeromonas salmonicida subsp. salmonicida A449]
1296 gene2123 VFG038332(gb|YP_001144282) (exsA) Type III secretion system transcriptional regulator [T3SS (VF0479)] [Aeromonas salmonicida subsp. salmonicida A449]
606 gene2126 VFG042278(gi:46398269) (exsC) ExsC [T3SS (SS032)] [Aeromonas hydrophila str. AH3]
3405 gene2132 VFG038342(gb|YP_001144292) (ascV) Type III secretion system inner membrane export apparatus protein AscV [T3SS (VF0479)] [Aeromonas salmonicida subsp. salmonicida A449]
464 gene2133 VFG038343(gb|YP_001144293) (ascY) chaperone protein [T3SS (VF0479)] [Aeromonas salmonicida subsp. salmonicida A449]
504 gene2134 VFG042269(gi:46398260) (ascX) AscX [T3SS (SS032)] [Aeromonas hydrophila str. AH3]
515 gene2135 VFG042268(gi:46398259) (acr2) Acr2 [T3SS (SS032)] [Aeromonas hydrophila str. AH3]
428 gene2136 VFG038346(gb|YP_001144296) (acr1) Type III secretion system gatekeeper subunit  [T3SS (VF0479)] [Aeromonas salmonicida subsp. salmonicida A449]
1357 gene2137 VFG038347(gb|YP_001144297) (aopN) AopN, secretion control of translocators and immune suppressor [T3SS (VF0479)] [Aeromonas salmonicida subsp. salmonicida A449]
2250 gene2138 VFG042265(gi:46398256) (ascN) AscN [T3SS (SS032)] [Aeromonas hydrophila str. AH3]
507 gene2139 VFG038349(gb|YP_001144299) (ascO) Type III secretion system protein AscO [T3SS (VF0479)] [Aeromonas salmonicida subsp. salmonicida A449]
1092 gene2141 VFG038351(gb|YP_001144301) (ascQ) type III secretion system protein AscQ [T3SS (VF0479)] [Aeromonas salmonicida subsp. salmonicida A449]
1088 gene2142 VFG038352(gb|YP_001144302) (ascR) Type III secretion system inner membrane export apparatus protein AscR [T3SS (VF0479)] [Aeromonas salmonicida subsp. salmonicida A449]
431 gene2143 VFG042260(gi:46398251) (ascS) AscS [T3SS (SS032)] [Aeromonas hydrophila str. AH3]
1135 gene2144 VFG042259(gi:46398250) (ascT) AscT [T3SS (SS032)] [Aeromonas hydrophila str. AH3]
1659 gene2145 VFG038355(gb|YP_001144305) (ascU) Type III secretion system inner membrane export apparatus protein AscU [T3SS (VF0479)] [Aeromonas salmonicida subsp. salmonicida A449]
3637 gene2154 VFG038500(gb|YP_857189) (tapV) type IV pilus assembly protein TapV [Tap type IV pili (CVF783)] [Aeromonas hydrophila subsp. hydrophila ATCC 7966]
3526 gene2451 VFG049190 (KOX_00005) protein disaggregation chaperone [T6SS-II (CVF861)] [Klebsiella oxytoca KCTC 1686]
1646 gene2485 VFG046474 (OOM_0626) elongation factor [EF-Tu (CVF827)] [Francisella noatunensis subsp. orientalis str. Toba 04]
1646 gene2502 VFG046474 (OOM_0626) elongation factor [EF-Tu (CVF827)] [Francisella noatunensis subsp. orientalis str. Toba 04]
241 gene2514 VFG045727(gi:289165404) (csrA) global regulator CsrA [Carbon storage regulator A (CVF362)] [Legionella longbeachae NSW150]
2845 gene2611 VFG038261(gi:507523517) (exeA) general secretion pathway protein A [Exe T2SS (VF0478)] [Aeromonas hydrophila ML09-119]
1009 gene2612 VFG038265(gi:507523518) (exeB) general secretion pathway protein B [Exe T2SS (VF0478)] [Aeromonas hydrophila ML09-119]
2992 gene2935 VFG038432(gi:507523593) (tapB) type IV pilus assembly ATPase [Tap type IV pili (VF0475)] [Aeromonas hydrophila ML09-119]
2171 gene2936 VFG038435(gb|YP_858309) (tapC) type IV fimbrial assembly protein, PilC-like [Tap type IV pili (CVF783)] [Aeromonas hydrophila subsp. hydrophila ATCC 7966]
1455 gene2937 VFG038317(gi:507523595) (tapD) prepilin peptidase [Exe T2SS (VF0478)] [Aeromonas hydrophila ML09-119]
1620 gene2963 VFG038890(gb|YP_001140314) (lafU) LafU, chemotaxis protein [Lateral flagella (VF0474)] [Aeromonas salmonicida subsp. salmonicida A449]
1478 gene2964 VFG038889(gb|YP_001140313) (lafT) LafT, flagella motor stator protein [Lateral flagella (VF0474)] [Aeromonas salmonicida subsp. salmonicida A449]
1138 gene2965 VFG043201(gi:13446369) (lafS) RNA polymerase sigma factor [ND (AI143)] [Aeromonas hydrophila str. AH-3]
752 gene2966 VFG038887(gb|YP_001140311) (lafF) LafF [Lateral flagella (VF0474)] [Aeromonas salmonicida subsp. salmonicida A449]
460 gene2968 VFG038885(gb|YP_001140309) (lafX) LafX [Lateral flagella (VF0474)] [Aeromonas salmonicida subsp. salmonicida A449]
659 gene2969 VFG043197(gi:13446365) (lafC) LafC [ND (AI143)] [Aeromonas hydrophila str. AH-3]
1987 gene2970 VFG038883(gb|YP_001140307) (lafB) flagellar hook associated protein LafB [Lateral flagella (VF0474)] [Aeromonas salmonicida subsp. salmonicida A449]
967 gene2971 VFG043195(gb|AAK20919) (lafA) lateral flagellin LafA [ND (AI143)] [Aeromonas hydrophila str. AH-3]
972 gene2972 VFG043195(gb|AAK20919) (lafA) lateral flagellin LafA [ND (AI143)] [Aeromonas hydrophila str. AH-3]
1518 gene2974 VFG038882(gb|YP_001140303) (maf-5) modification accessory factor [Lateral flagella (VF0474)] [Aeromonas salmonicida subsp. salmonicida A449]
1357 gene2975 VFG038881(gb|YP_001140302) (lfgL) lateral flagellar hook-associated protein, LfgL [Lateral flagella (VF0474)] [Aeromonas salmonicida subsp. salmonicida A449]
2225 gene2976 VFG038880(gb|YP_001140301) (lfgK) lateral flagellar hook-associated protein [Lateral flagella (VF0474)] [Aeromonas salmonicida subsp. salmonicida A449]
658 gene2977 VFG043191(gi:74101663) (flgJ) FlgJL [ND (AI143)] [Aeromonas hydrophila str. AH-3]
1846 gene2978 VFG038878(gb|YP_001140299) (flgI) flagellar basal body P-ring protein [Lateral flagella (VF0474)] [Aeromonas salmonicida subsp. salmonicida A449]
1150 gene2979 VFG038877(gb|YP_001140298) (lfgH) lateral flagellar L-ring protein, LfgH [Lateral flagella (VF0474)] [Aeromonas salmonicida subsp. salmonicida A449]
1363 gene2980 VFG043188(gi:74101660) (flgG) FlgGL [ND (AI143)] [Aeromonas hydrophila str. AH-3]
1208 gene2981 VFG043187(gi:74101659) (flgF) FlgFL [ND (AI143)] [Aeromonas hydrophila str. AH-3]
2022 gene2982 VFG043186(gi:74101658) (flgE) FlgEL [ND (AI143)] [Aeromonas hydrophila str. AH-3]
1117 gene2983 VFG043185(gi:74101657) (flgD) FlgDL [ND (AI143)] [Aeromonas hydrophila str. AH-3]
715 gene2984 VFG043184(gi:74101656) (flgC) FlgCL [ND (AI143)] [Aeromonas hydrophila str. AH-3]
653 gene2985 VFG043183(gi:74101655) (flgB) FlgBL [ND (AI143)] [Aeromonas hydrophila str. AH-3]
1080 gene2986 VFG043182(gi:74101654) (flgA) FlgAL [ND (AI143)] [Aeromonas hydrophila str. AH-3]
382 gene2987 VFG038870(gb|YP_001140291) (lfgM) lateral flagella anti-sigma-28 factor, LfgM [Lateral flagella (VF0474)] [Aeromonas salmonicida subsp. salmonicida A449]
438 gene2988 VFG043180(gi:74101652) (flgN) FlgNL [ND (AI143)] [Aeromonas hydrophila str. AH-3]
545 gene2989 VFG043179(gi:74101651) (fliJ) FliJL [ND (AI143)] [Aeromonas hydrophila str. AH-3]
2137 gene2990 VFG043178(gi:74101650) (fliI) FliIL [ND (AI143)] [Aeromonas hydrophila str. AH-3]
1104 gene2991 VFG043177(gi:74101649) (fliH) FliHL [ND (AI143)] [Aeromonas hydrophila str. AH-3]
1759 gene2992 VFG043176(gi:74101648) (fliG) FliGL [ND (AI143)] [Aeromonas hydrophila str. AH-3]
2836 gene2993 VFG038864(gb|YP_001140285) (fliF) flagellar MS-ring protein [Lateral flagella (VF0474)] [Aeromonas salmonicida subsp. salmonicida A449]
487 gene2994 VFG043174(gi:74101646) (fliE) FliEL [ND (AI143)] [Aeromonas hydrophila str. AH-3]
2017 gene2995 VFG038862(gb|YP_001140283) (lafK) two-component system lateral flagellar response regulator [Lateral flagella (VF0474)] [Aeromonas salmonicida subsp. salmonicida A449]
3492 gene2996 VFG043172(gi:74101644) (flhA) FlhAL [ND (AI143)] [Aeromonas hydrophila str. AH-3]
1938 gene2997 VFG043171(gi:74101643) (flhB) FlhBL [ND (AI143)] [Aeromonas hydrophila str. AH-3]
1204 gene2998 VFG038859(gb|YP_001140280) (lfiR) lateral flagellar biosynthetic protein LfiR [Lateral flagella (VF0474)] [Aeromonas salmonicida subsp. salmonicida A449]
355 gene2999 VFG038858(gb|YP_001140279) (lfiQ) lateral flagellar biosynthetic protein, LfiQ [Lateral flagella (VF0474)] [Aeromonas salmonicida subsp. salmonicida A449]
1048 gene3000 VFG038857(gb|YP_001140278) (fliP) flagellar biosynthesis protein FliP [Lateral flagella (VF0474)] [Aeromonas salmonicida subsp. salmonicida A449]
615 gene3001 VFG043167(gi:74101639) (fliN) FliNL [ND (AI143)] [Aeromonas hydrophila str. AH-3]
1323 gene3002 VFG043166(gi:74101638) (fliM) FliML [ND (AI143)] [Aeromonas hydrophila str. AH-3]
3004 gene3186 VFG038367(gb|YP_855660) (vgrG1) Type VI secretion system effector VgrG1, ADP-ribosyltransferase  [VgrG1 (TX001)] [Aeromonas hydrophila subsp. hydrophila ATCC 7966]
2078 gene3191 VFG038377(gi:145297534) (ASA_0454) lipoprotein [T6SS (CVF782)] [Aeromonas salmonicida subsp. salmonicida A449]
927 gene3194 VFG038370(gi:507521520) (hcp) HcpA-like protein [T6SS (VF0480)] [Aeromonas hydrophila ML09-119]
287 gene3195 VFG038405(gi:117619593) (AHA_1847) PAAR motif-containing protein [T6SS (SS194)] [Aeromonas hydrophila subsp. hydrophila ATCC 7966]
3291 gene3196 VFG038368(gi:507520712) (vgrG1) Rhs element Vgr protein [T6SS (VF0480)] [Aeromonas hydrophila ML09-119]
1914 gene3326 VFG044235(gb|YP_856993) (amoA) isochorismate synthases [amonabactin (IA020)] [Aeromonas hydrophila subsp. hydrophila ATCC 7966]
1249 gene3728 VFG000477(gi:16766230) (rpoS) sigma S (sigma 38) factor of RNA polymerase, major sigmafactor during stationary phase [RpoS (VF0112)] [Salmonella enterica subsp. enterica serovar Typhimurium str. LT2]
3337 gene3754 VFG038895(gb|YP_855347) (ast) thermostable cytotonic enterotoxin [Heat-stable cytotonic enterotoxin, Ast (CVF789)] [Aeromonas hydrophila subsp. hydrophila ATCC 7966]
1520 gene3780 VFG013612(gi:113461676) (hemE) uroporphyrinogen decarboxylase [Heme biosynthesis (CVF506)] [Haemophilus somnus 129PT]
2496 gene3882 VFG042293(gi:111143381) (aexU) AexT-like protein [T3SS (SS032)] [Aeromonas hydrophila str. SSU]
1368 gene3918 VFG013197(gi:170717931) (hemB) Porphobilinogen synthase [Heme biosynthesis (CVF506)] [Haemophilus somnus 2336]
1262 gene3965 VFG038840(gi:507521851) (flmH) flagellar-related 3-oxoacyl-ACP reductase [Polar flagella (VF0473)] [Aeromonas hydrophila ML09-119]
1981 gene4068 VFG038471(gb|YP_857247) (tapW) twitching ATPase [Tap type IV pili (CVF783)] [Aeromonas hydrophila subsp. hydrophila ATCC 7966]
1813 gene4139 VFG038463(gb|YP_858121) (tapT) twitching ATPase [Tap type IV pili (CVF783)] [Aeromonas hydrophila subsp. hydrophila ATCC 7966]
1933 gene4140 VFG038467(gb|YP_858122) (tapU) twitching ATPase [Tap type IV pili (CVF783)] [Aeromonas hydrophila subsp. hydrophila ATCC 7966]
3876 gene4156 VFG042801(gi:145300516) (tapZ) type IV pilus assembly TapZ [Tap pili (AI103)] [Aeromonas salmonicida subsp. salmonicida A449]
1076 gene4168 VFG038496(gb|YP_858148) (tppF) type IV pilus pseudopilin [Tap type IV pili (CVF783)] [Aeromonas hydrophila subsp. hydrophila ATCC 7966]
2255 gene4231 VFG013532(gi:148826097) (pgi) glucose-6-phosphate isomerase [Exopolysaccharide (CVF495)] [Haemophilus influenzae PittEE]
930 gene4277 VFG038365(gb|YP_855659) (hcp1) HcpA-like protein [T6SS (CVF782)] [Aeromonas hydrophila subsp. hydrophila ATCC 7966]
3572 gene4278 VFG038407(gb|YP_856382) (vgrG) VgrG protein [T6SS (SS194)] [Aeromonas hydrophila subsp. hydrophila ATCC 7966]
1061 gene4404 VFG038905(gi:507523204) (AHML_18530) hemolysin [Hemolysin III (CVF793)] [Aeromonas hydrophila ML09-119]
2020 gene4466 VFG010484(gi:54296712) (htpB) 60 kDa chaperonin (Protein Cpn60)(groEL protein)(Heat shock protein B). [Hsp60 (CVF347)] [Legionella pneumophila str. Paris]
722 gene4527 VFG038370(gi:507521520) (hcp) HcpA-like protein [T6SS (VF0480)] [Aeromonas hydrophila ML09-119]

Table S6. Genome annotation by VFDB(A12)

Score

Query-Name

Hit-Name

Description

2339

gene69

VFG038848(gi:507521398)

(flmD) flagellar-related pseudaminic acid biosynthesis-associated protein [Polar flagella (VF0473)] [Aeromonas hydrophila ML09-119]

1660

gene70

VFG038851(gi:507521397)

(nueB) flagellar-related pseudaminic acid synthase [Polar flagella (VF0473)] [Aeromonas hydrophila ML09-119]

529

gene74

VFG038746(gb|YP_856238)

(flaJ) flagellar specific chaperone FlaJ/FliS [ND (AI144)] [Aeromonas hydrophila subsp. hydrophila ATCC 7966]

1669

gene75

VFG038744(gi:145299587)

(flaH) flagellar hook-associated protein 2 [Polar flagella (CVF786)] [Aeromonas salmonicida subsp. salmonicida A449]

1237

gene76

VFG038734(gb|YP_856235)

(flaB) flagellin [ND (AI144)] [Aeromonas hydrophila subsp. hydrophila ATCC 7966]

1205

gene77

VFG038730(gb|YP_856234)

(flaA) flagellin [ND (AI144)] [Aeromonas hydrophila subsp. hydrophila ATCC 7966]

1955

gene131

VFG038474(gi:330829098)

(tapW) Tfp pilus assembly protein, ATPase PilU [Tap type IV pili (CVF783)] [Aeromonas veronii B565]

823

gene298

VFG013171(gi:170719013)

(gmhA/lpcA) phosphoheptose isomerase [LOS (CVF494)] [Haemophilus somnus 2336]

823

gene396

VFG043204(gb|YP_855930)

(cheW-2) chemotaxis protein CheW [ND (AI144)] [Aeromonas hydrophila subsp. hydrophila ATCC 7966]

1489

gene397

VFG038729(gi:330828824)

(cheW) CheW domain-containing protein [Polar flagella (CVF786)] [Aeromonas veronii B565]

1396

gene398

VFG038725(gi:330828823)

(B565_1123) CobQ/CobB/MinD/ParA family protein [Polar flagella (CVF786)] [Aeromonas veronii B565]

1575

gene399

VFG038721(gi:330828822)

(pomB) OmpA family protein [Polar flagella (CVF786)] [Aeromonas veronii B565]

1231

gene400

VFG038717(gi:330828821)

(pomA) MotA/TolQ/ExbB proton channel [Polar flagella (CVF786)] [Aeromonas veronii B565]

1918

gene401

VFG038713(gi:330828820)

(cheB-2) two component system response-regulator/protein-glutamate methylesterase CheB [Polar flagella (CVF786)] [Aeromonas veronii B565]

3716

gene402

VFG038709(gi:330828819)

(cheA-2) transducing histidine kinase [Polar flagella (CVF786)] [Aeromonas veronii B565]

1288

gene403

VFG038705(gi:330828818)

(cheZ) chemotaxis protein CheZ [Polar flagella (CVF786)] [Aeromonas veronii B565]

640

gene404

VFG038701(gi:330828817)

(cheY) response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Polar flagella (CVF786)] [Aeromonas veronii B565]

1155

gene405

VFG038696(gi:145298363)

(fliA) flagellar biosynthesis sigma factor [Polar flagella (CVF786)] [Aeromonas salmonicida subsp. salmonicida A449]

1543

gene406

VFG038693(gi:330828815)

(flhG) CobQ/CobB/MinD/ParA family protein [Polar flagella (CVF786)] [Aeromonas veronii B565]

2500

gene407

VFG038689(gi:330828814)

(flhF) flagellar biosynthesis protein FlhF [Polar flagella (CVF786)] [Aeromonas veronii B565]

3609

gene408

VFG038685(gi:330828813)

(flhA) flagellar biosynthesis protein FlhA [Polar flagella (CVF786)] [Aeromonas veronii B565]

1966

gene409

VFG038681(gi:330828812)

(flhB) flagellar biosynthetic protein FlhB [Polar flagella (CVF786)] [Aeromonas veronii B565]

1279

gene410

VFG038677(gi:330828811)

(fliR) flagellar biosynthetic protein fliR [Polar flagella (CVF786)] [Aeromonas veronii B565]

428

gene411

VFG038673(gi:330828810)

(fliQ) flagellar biosynthetic protein FliQ [Polar flagella (CVF786)] [Aeromonas veronii B565]

1312

gene412

VFG038669(gi:330828809)

(fliP) flagellar biosynthetic protein FliP [Polar flagella (CVF786)] [Aeromonas veronii B565]

622

gene413

VFG038665(gi:330828808)

(fliO) flagellar biosynthesis protein, FliO [Polar flagella (CVF786)] [Aeromonas veronii B565]

653

gene414

VFG038661(gi:330828807)

(fliN) flagellar motor switch phosphatase FliY [Polar flagella (CVF786)] [Aeromonas veronii B565]

1852

gene415

VFG038657(gi:330828806)

(fliM) flagellar motor switch protein FliM [Polar flagella (CVF786)] [Aeromonas veronii B565]

857

gene416

VFG038653(gi:330828805)

(fliL) flagellar basal body-associated protein FliL [Polar flagella (CVF786)] [Aeromonas veronii B565]

2726

gene417

VFG038649(gi:330828804)

(fliK) putative polar flagellar hook-length control protein FliK [Polar flagella (CVF786)] [Aeromonas veronii B565]

736

gene418

VFG038645(gi:330828803)

(fliJ) flagellar protein FliJ [Polar flagella (CVF786)] [Aeromonas veronii B565]

2281

gene419

VFG038641(gi:330828802)

(fliI) flagellar protein export ATPase FliI [Polar flagella (CVF786)] [Aeromonas veronii B565]

1395

gene420

VFG038637(gi:330828801)

(fliH) flagellar assembly protein FliH [Polar flagella (CVF786)] [Aeromonas veronii B565]

1823

gene421

VFG038633(gi:330828800)

(fliG) flagellar motor switch protein FliG [Polar flagella (CVF786)] [Aeromonas veronii B565]

2979

gene422

VFG038629(gi:330828799)

(fliF) flagellar M-ring protein FliF [Polar flagella (CVF786)] [Aeromonas veronii B565]

522

gene423

VFG038624(gi:145298345)

(fliE) flagellar hook-basal body protein [Polar flagella (CVF786)] [Aeromonas salmonicida subsp. salmonicida A449]

1213

gene516

VFG013465(gb|NP_439706)

(kdsA) 2-dehydro-3-deoxyphosphooctonate aldolase [LOS (CVF494)] [Haemophilus influenzae Rd KW20]

3775

gene552

VFG038462(gi:330828668)

(tapQ) type IV pilus secretin PilQ [Tap type IV pili (CVF783)] [Aeromonas veronii B565]

936

gene553

VFG038458(gi:330828667)

(tapP) type IV pilus biogenesis protein PilP [Tap type IV pili (CVF783)] [Aeromonas veronii B565]

1060

gene554

VFG038454(gi:330828666)

(tapO) type IV pilus biogenesis protein PilO [Tap type IV pili (CVF783)] [Aeromonas veronii B565]

983

gene555

VFG038450(gi:330828665)

(tapN) type IV pilus biogenesis PilN [Tap type IV pili (CVF783)] [Aeromonas veronii B565]

1841

gene556

VFG038446(gi:330828664)

(tapM) type IV pilus biogenesis protein PilM [Tap type IV pili (CVF783)] [Aeromonas veronii B565]

1157

gene582

VFG038911(gi:330828638)

(B565_0938) Thermostable hemolysin [Thermostable hemolysin (TH) (CVF794)] [Aeromonas veronii B565]

3035

gene675

VFG044242(gi:145300215)

(hutA) outer-membrane heme receptor [direct heme uptake system (IA062)] [Aeromonas salmonicida subsp. salmonicida A449]

1233

gene676

VFG044243(gi:145300216)

(ASA_3329) iron-regulated protein [direct heme uptake system (IA062)] [Aeromonas salmonicida subsp. salmonicida A449]

700

gene677

VFG044244(gi:145300217)

(ASA_3330) isochorismatase family protein [direct heme uptake system (IA062)] [Aeromonas salmonicida subsp. salmonicida A449]

925

gene679

VFG044246(gi:145300219)

(hutZ) heme iron utilization protein [direct heme uptake system (IA062)] [Aeromonas salmonicida subsp. salmonicida A449]

789

gene680

VFG044247(gi:145300220)

(hutX) heme iron utilization protein [direct heme uptake system (IA062)] [Aeromonas salmonicida subsp. salmonicida A449]

1064

gene681

VFG044248(gi:145300221)

(hutB) ABC-type hemin transporter, periplasmic component [direct heme uptake system (IA062)] [Aeromonas salmonicida subsp. salmonicida A449]

1159

gene682

VFG044249(gi:145300222)

(hutC) ABC-type hemin transporter, permease protein [direct heme uptake system (IA062)] [Aeromonas salmonicida subsp. salmonicida A449]

1131

gene683

VFG044250(gi:145300223)

(hutD) ABC-type hemin transporter, ATP-binding protein [direct heme uptake system (IA062)] [Aeromonas salmonicida subsp. salmonicida A449]

1380

gene991

VFG038833(gi:145298724)

(pomB2) flagellar motor protein MotB [Polar flagella (CVF786)] [Aeromonas salmonicida subsp. salmonicida A449]

1255

gene1023

VFG038507(gi:330830070)

(tapF) type IV pilus biogenesis/stability protein PilW [Tap type IV pili (CVF783)] [Aeromonas veronii B565]

1078

gene1054

VFG005997(gi:24379858)

(rmlA) putative glucose-1-phosphate thymidyltransferase [Capsule (CVF186)] [Streptococcus mutans UA159]

631

gene1148

VFG000478(gi:16764063)

(fur) transcriptional repressor of iron-responsive genes (Fur family) (ferric uptake regulator) [Fur (VF0113)] [Salmonella enterica subsp. enterica serovar Typhimurium str. LT2]

609

gene1203

VFG038830(gi:330830311)

(flgN) flagellar biosynthetic protein FlgN [Polar flagella (CVF786)] [Aeromonas veronii B565]

525

gene1204

VFG038826(gi:330830310)

(flgM) anti-sigma-D factor [Polar flagella (CVF786)] [Aeromonas veronii B565]

1166

gene1205

VFG038822(gi:330830309)

(flgA) flagellar basal body P-ring biosynthesis protein FlgA [Polar flagella (CVF786)] [Aeromonas veronii B565]

1593

gene1206

VFG038818(gi:330830308)

(cheV) chemotaxis protein methyltransferase CheV [Polar flagella (CVF786)] [Aeromonas veronii B565]

1452

gene1207

VFG038814(gi:330830307)

(cheR-3) CheR methyltransferase [Polar flagella (CVF786)] [Aeromonas veronii B565]

699

gene1208

VFG038810(gi:330830306)

(flgB) flagellar basal-body rod protein FlgB [Polar flagella (CVF786)] [Aeromonas veronii B565]

727

gene1209

VFG038806(gi:330830305)

(flgC) flagellar basal-body rod protein FlgC [Polar flagella (CVF786)] [Aeromonas veronii B565]

1256

gene1210

VFG038802(gi:330830304)

(flgD) flagellar hook capping protein [Polar flagella (CVF786)] [Aeromonas veronii B565]

1929

gene1211

VFG038798(gi:330830303)

(flgE) flagellar hook protein FlgE [Polar flagella (CVF786)] [Aeromonas veronii B565]

1299

gene1212

VFG038794(gi:330830302)

(flgF) flagellar basal-body rod protein FlgF [Polar flagella (CVF786)] [Aeromonas veronii B565]

1359

gene1213

VFG038790(gi:330830301)

(flgG) flagellar basal body rod protein FlgG [Polar flagella (CVF786)] [Aeromonas veronii B565]

1151

gene1214

VFG038786(gi:330830300)

(flgH) flagellar L-ring protein [Polar flagella (CVF786)] [Aeromonas veronii B565]

1877

gene1215

VFG038782(gi:330830299)

(flgI) flagellar P-ring protein FlgI [Polar flagella (CVF786)] [Aeromonas veronii B565]

1884

gene1216

VFG038778(gi:330830298)

(flgJ) peptidoglycan hydrolase FlgJ [Polar flagella (CVF786)] [Aeromonas veronii B565]

3413

gene1217

VFG038774(gi:330830297)

(flgK) flagellar hook-associated protein FlgK [Polar flagella (CVF786)] [Aeromonas veronii B565]

1997

gene1218

VFG038770(gi:330830296)

(flgL) flagellar hook-associated protein 3 [Polar flagella (CVF786)] [Aeromonas veronii B565]

2457

gene1224

VFG038766(gi:330830290)

(flrA) FleQ protein [Polar flagella (CVF786)] [Aeromonas veronii B565]

1792

gene1225

VFG038762(gi:330830289)

(flrB) two component system flagellar sensor histidine kinase FlrB [Polar flagella (CVF786)] [Aeromonas veronii B565]

2334

gene1226

VFG038758(gi:330830288)

(flrC) Fis family two component sigma54 specific transcriptional regulator [Polar flagella (CVF786)] [Aeromonas veronii B565]

2315

gene1241

VFG038903(gi:330830274)

(hlyA) putative transporter [Hemolysin HlyA (CVF792)] [Aeromonas veronii B565]

1439

gene1273

VFG038754(gi:145299432)

(motY) sodium-type polar flagellum motor protein [Polar flagella (CVF786)] [Aeromonas salmonicida subsp. salmonicida A449]

3644

gene1514

VFG038503(gi:330829260)

(tapV) Motility protein FimV [Tap type IV pili (CVF783)] [Aeromonas veronii B565]

2900

gene1581

VFG001862(gb|YP_096397)

(katB) catalase-peroxidase KatB [KatAB (VF0168)] [Legionella pneumophila subsp. pneumophila str. Philadelphia 1]

1432

gene1695

VFG038319(gi:330828057)

(tapD) N-methyltransferase [T2SS (CVF780)] [Aeromonas veronii B565]

2173

gene1696

VFG038438(gi:330828058)

(tapC) type IV pilus assembly protein tapC [Tap type IV pili (CVF783)] [Aeromonas veronii B565]

3005

gene1697

VFG038434(gi:330828059)

(tapB) type IV-A pilus assembly ATPase PilB [Tap type IV pili (CVF783)] [Aeromonas veronii B565]

1226

gene1993

VFG038840(gi:507521851)

(flmH) flagellar-related 3-oxoacyl-ACP reductase [Polar flagella (VF0473)] [Aeromonas hydrophila ML09-119]

2035

gene2006

VFG010484(gi:54296712)

(htpB) 60 kDa chaperonin (Protein Cpn60)(groEL protein)(Heat shock protein B). [Hsp60 (CVF347)] [Legionella pneumophila str. Paris]

3473

gene2065

VFG042801(gi:145300516)

(tapZ) type IV pilus assembly TapZ [Tap pili (AI103)] [Aeromonas salmonicida subsp. salmonicida A449]

718

gene2079

VFG018241(gb|NP_230208)

(luxS) S-ribosylhomocysteinase [AI-2 (VF0406)] [Vibrio cholerae O1 biovar El Tor str. N16961]

685

gene2083

VFG038495(gi:330831162)

(tppE) putative type IV pilus biogenesis protein [Tap type IV pili (CVF783)] [Aeromonas veronii B565]

475

gene2085

VFG038491(gi:330831164)

(tapY2) TapY2 protein [Tap type IV pili (CVF783)] [Aeromonas veronii B565]

4971

gene2086

VFG038490(gi:330831165)

(tapY1) TapY1 protein [Tap type IV pili (CVF783)] [Aeromonas veronii B565]

631

gene2087

VFG038486(gi:330831166)

(tppD) hypothetical protein [Tap type IV pili (CVF783)] [Aeromonas veronii B565]

1474

gene2088

VFG038484(gi:330831167)

(tppC) TppC protein [Tap type IV pili (CVF783)] [Aeromonas veronii B565]

972

gene2089

VFG038482(gi:330831168)

(tppB) type IV pilus assembly protein [Tap type IV pili (CVF783)] [Aeromonas veronii B565]

682

gene2090

VFG038478(gi:330831169)

(tppA) TppA protein [Tap type IV pili (CVF783)] [Aeromonas veronii B565]

1078

gene2117

VFG038621(gi:330831196)

(motX) sodium-type flagellar motor component [Polar flagella (CVF786)] [Aeromonas veronii B565]

1958

gene2133

VFG038470(gi:330831212)

(tapU) Twitching motility protein PilU [Tap type IV pili (CVF783)] [Aeromonas veronii B565]

1805

gene2134

VFG038466(gi:330831213)

(tapT) Pilus retraction ATPase PilT [Tap type IV pili (CVF783)] [Aeromonas veronii B565]

1611

gene2367

VFG013517(gi:113460873)

(mrsA/glmM) phosphoglucosamine mutase [Exopolysaccharide (CVF495)] [Haemophilus somnus 129PT]

1468

gene2374

VFG038834(gi:330830900)

(pomB2) sodium-driven polar flagellar protein [Polar flagella (CVF786)] [Aeromonas veronii B565]

1287

gene2375

VFG038838(gi:330830901)

(pomA2) chemotaxis protein PomA [Polar flagella (CVF786)] [Aeromonas veronii B565]

804

gene2559

VFG038427(gi:330828180)

(fimF) Fimbrial protein [Type I fimbriae (CVF796)] [Aeromonas veronii B565]

1251

gene2561

VFG038419(gi:330828178)

(fimD) Fimbrial chaperone protein [Type I fimbriae (CVF796)] [Aeromonas veronii B565]

4506

gene2562

VFG038415(gi:330828177)

(fimC) outer membrane usher protein [Type I fimbriae (CVF796)] [Aeromonas veronii B565]

714

gene2564

VFG038410(gi:145300593)

(fimA) type I pilus pilin protein FimA [Type I fimbriae (CVF796)] [Aeromonas salmonicida subsp. salmonicida A449]

239

gene2932

VFG010907(gi:54296805)

(csrA) global regulator CsrA [Carbon storage regulator A (CVF362)] [Legionella pneumophila str. Paris]

2598

gene2957

VFG044037(gi:26245425)

(AAN77507) hemolysin [aerolysin (TX452)] [Aeromonas sobria str. 357]

3651

gene2989

VFG038563(gi:330831354)

(mshQ) MshQ protein [Mannose-sensitive hemagglutinin (Msh) pilus, type IV pili (CVF785)] [Aeromonas veronii B565]

693

gene2991

VFG038565(gi:145300798)

(mshP) MSHA biogenesis protein MshP [Mannose-sensitive hemagglutinin (Msh) pilus, type IV pili (CVF785)] [Aeromonas salmonicida subsp. salmonicida A449]

1453

gene2992

VFG038569(gi:145300799)

(mshO) MSHA biogenesis protein MshO [Mannose-sensitive hemagglutinin (Msh) pilus, type IV pili (CVF785)] [Aeromonas salmonicida subsp. salmonicida A449]

960

gene2993

VFG038574(gi:330831357)

(mshD) MSHA biogenesis protein MshN/MshD [Mannose-sensitive hemagglutinin (Msh) pilus, type IV pili (CVF785)] [Aeromonas veronii B565]

643

gene2994

VFG038576(gi:507519910)

(mshC) MSHA pilin protein mshC [MSHA type IV pili (VF0477)] [Aeromonas hydrophila ML09-119]

427

gene2995

VFG038578(gi:507519909)

(mshB) MSHA pilin protein MshA [MSHA type IV pili (VF0477)] [Aeromonas hydrophila ML09-119]

1164

gene2996

VFG038582(gi:330831360)

(mshA) Msha pilin protein mshb [Mannose-sensitive hemagglutinin (Msh) pilus, type IV pili (CVF785)] [Aeromonas veronii B565]

773

gene2997

VFG038585(gi:330831361)

(mshF) hypothetical protein [Mannose-sensitive hemagglutinin (Msh) pilus, type IV pili (CVF785)] [Aeromonas veronii B565]

2100

gene2998

VFG038588(gi:330831362)

(mshG) GspF family protein [Mannose-sensitive hemagglutinin (Msh) pilus, type IV pili (CVF785)] [Aeromonas veronii B565]

2971

gene2999

VFG038591(gi:330831363)

(mshE) type IV pilin [Mannose-sensitive hemagglutinin (Msh) pilus, type IV pili (CVF785)] [Aeromonas veronii B565]

1837

gene3000

VFG038594(gi:330831364)

(mshN) hypothetical protein [Mannose-sensitive hemagglutinin (Msh) pilus, type IV pili (CVF785)] [Aeromonas veronii B565]

1509

gene3001

VFG038598(gi:330831365)

(mshM) general secretion pathway protein A [Mannose-sensitive hemagglutinin (Msh) pilus, type IV pili (CVF785)] [Aeromonas veronii B565]

2945

gene3002

VFG038602(gi:330831366)

(mshL) MSHA biogenesis protein MshL [Mannose-sensitive hemagglutinin (Msh) pilus, type IV pili (CVF785)] [Aeromonas veronii B565]

543

gene3003

VFG038605(gi:330831367)

(mshK) MSHA biogenesis protein MshK [Mannose-sensitive hemagglutinin (Msh) pilus, type IV pili (CVF785)] [Aeromonas veronii B565]

1104

gene3004

VFG038609(gi:330831368)

(mshJ) MSHA biogenesis protein MshJ [Mannose-sensitive hemagglutinin (Msh) pilus, type IV pili (CVF785)] [Aeromonas veronii B565]

1003

gene3005

VFG038613(gi:330831369)

(mshI1) MSHA biogenesis protein MshI1 [Mannose-sensitive hemagglutinin (Msh) pilus, type IV pili (CVF785)] [Aeromonas veronii B565]

1387

gene3006

VFG038617(gi:330831370)

(mshI) MSHA biogenesis protein MshI [Mannose-sensitive hemagglutinin (Msh) pilus, type IV pili (CVF785)] [Aeromonas veronii B565]

198

gene3054

VFG046474

(OOM_0626) elongation factor [EF-Tu (CVF827)] [Francisella noatunensis subsp. orientalis str. Toba 04]

3526

gene3088

VFG049190

(KOX_00005) protein disaggregation chaperone [T6SS-II (CVF861)] [Klebsiella oxytoca KCTC 1686]

1443

gene3193

VFG007659(gi:59710773)

(rmlB) dTDP-glucose 4,6-dehydratase [Capsular polysaccharide (CVF282)] [Vibrio fischeri ES114]

1471

gene3195

VFG037926(gi:215485082)

(ABBFA_003451) spore coat polysaccharide biosynthesis protein spsC [Capsule (CVF775)] [Acinetobacter baumannii AB307-0294]

679

gene3197

VFG007642(gi:37678545)

(wcaJ) putative UDP-galactose phosphate transferase [Capsular polysaccharide (CVF282)] [Vibrio vulnificus YJ016]

1464

gene3208

VFG014103(gi:15598351)

(wbpE) probable aminotransferase WbpE [LPS O-antigen (P. aeruginosa) (CVF520)] [Pseudomonas aeruginosa PAO1]

853

gene3209

VFG037928(gi:126640167)

(A1S_0054) WbbJ protein [Capsule (CVF775)] [Acinetobacter baumannii ATCC 17978]

3880

gene3212

VFG049139

(acrB) acriflavine resistance protein B [AcrAB (CVF859)] [Klebsiella pneumoniae 342]

2747

gene3310

VFG038263(gi:330830587)

(exeA) general secretion pathway protein A [T2SS (CVF780)] [Aeromonas veronii B565]

1131

gene3311

VFG038267(gi:330830588)

(exeB) general secretion pathway protein B [T2SS (CVF780)] [Aeromonas veronii B565]

1435

gene3313

VFG038271(gi:330830589)

(exeC) general secretion pathway protein C [T2SS (CVF780)] [Aeromonas veronii B565]

3534

gene3314

VFG038275(gi:330830590)

(exeD) general secretion pathway protein D [T2SS (CVF780)] [Aeromonas veronii B565]

2595

gene3315

VFG038279(gi:330830591)

(exeE) type II secretory pathway, ATPase PulE-like protein [T2SS (CVF780)] [Aeromonas veronii B565]

2123

gene3316

VFG038283(gi:330830592)

(exeF) general secretion pathway protein F [T2SS (CVF780)] [Aeromonas veronii B565]

744

gene3317

VFG038287(gi:330830593)

(exeG) Pullulanase G protein [T2SS (CVF780)] [Aeromonas veronii B565]

936

gene3318

VFG038291(gi:330830594)

(exeH) general secretion pathway protein H [T2SS (CVF780)] [Aeromonas veronii B565]

618

gene3319

VFG038295(gi:330830595)

(exeI) general secretion pathway protein I [T2SS (CVF780)] [Aeromonas veronii B565]

1267

gene3320

VFG038299(gi:330830596)

(exeJ) general secretion pathway protein J [T2SS (CVF780)] [Aeromonas veronii B565]

1727

gene3321

VFG038303(gi:330830597)

(exeK) general secretion pathway protein K [T2SS (CVF780)] [Aeromonas veronii B565]

2012

gene3322

VFG038307(gi:330830598)

(exeL) general secretion pathway protein L [T2SS (CVF780)] [Aeromonas veronii B565]

823

gene3323

VFG038311(gi:330830599)

(exeM) general secretion pathway protein M [T2SS (CVF780)] [Aeromonas veronii B565]

1188

gene3324

VFG038315(gi:330830600)

(exeN) general secretion pathway protein N [T2SS (CVF780)] [Aeromonas veronii B565]

1260

gene3569

VFG000477(gi:16766230)

(rpoS) sigma S (sigma 38) factor of RNA polymerase, major sigmafactor during stationary phase [RpoS (VF0112)] [Salmonella enterica subsp. enterica serovar Typhimurium str. LT2]

1235

gene3698

VFG038845(gi:507522470)

(nueA) flagellar-related 3-deoxy-D-manno-octulosonate cytidylyltransferase [Polar flagella (VF0473)] [Aeromonas hydrophila ML09-119]

1400

gene3753

VFG013197(gi:170717931)

(hemB) Porphobilinogen synthase [Heme biosynthesis (CVF506)] [Haemophilus somnus 2336]

1517

gene3777

VFG013612(gi:113461676)

(hemE) uroporphyrinogen decarboxylase [Heme biosynthesis (CVF506)] [Haemophilus somnus 129PT]

1043

gene3809

VFG038907(gi:330828499)

(B565_0799) Hemolysin III [Hemolysin III (CVF793)] [Aeromonas veronii B565]

2267

gene3859

VFG013531(gi:68249838)

(pgi) glucose-6-phosphate isomerase [Exopolysaccharide (CVF495)] [Haemophilus influenzae 86-028NP]

408

gene3945

VFG016493(gi:71894677)

(tuf) Elongation factor Tu [EF-Tu (CVF587)] [Mycoplasma synoviae 53]

623

gene3963

VFG046474

(OOM_0626) elongation factor [EF-Tu (CVF827)] [Francisella noatunensis subsp. orientalis str. Toba 04]

Table S7. Genome annotation by VFDB(A15)

Score

Query-Name

Hit-Name

Description

522

gene64

VFG038624(gi:145298345)

(fliE) flagellar hook-basal body protein [Polar flagella (CVF786)] [Aeromonas salmonicida subsp. salmonicida A449]

2973

gene65

VFG038629(gi:330828799)

(fliF) flagellar M-ring protein FliF [Polar flagella (CVF786)] [Aeromonas veronii B565]

1823

gene66

VFG038633(gi:330828800)

(fliG) flagellar motor switch protein FliG [Polar flagella (CVF786)] [Aeromonas veronii B565]

1391

gene67

VFG038637(gi:330828801)

(fliH) flagellar assembly protein FliH [Polar flagella (CVF786)] [Aeromonas veronii B565]

2288

gene68

VFG038641(gi:330828802)

(fliI) flagellar protein export ATPase FliI [Polar flagella (CVF786)] [Aeromonas veronii B565]

736

gene69

VFG038645(gi:330828803)

(fliJ) flagellar protein FliJ [Polar flagella (CVF786)] [Aeromonas veronii B565]

2707

gene70

VFG038649(gi:330828804)

(fliK) putative polar flagellar hook-length control protein FliK [Polar flagella (CVF786)] [Aeromonas veronii B565]

862

gene71

VFG038653(gi:330828805)

(fliL) flagellar basal body-associated protein FliL [Polar flagella (CVF786)] [Aeromonas veronii B565]

1852

gene72

VFG038657(gi:330828806)

(fliM) flagellar motor switch protein FliM [Polar flagella (CVF786)] [Aeromonas veronii B565]

649

gene73

VFG038661(gi:330828807)

(fliN) flagellar motor switch phosphatase FliY [Polar flagella (CVF786)] [Aeromonas veronii B565]

614

gene74

VFG038665(gi:330828808)

(fliO) flagellar biosynthesis protein, FliO [Polar flagella (CVF786)] [Aeromonas veronii B565]

1312

gene75

VFG038669(gi:330828809)

(fliP) flagellar biosynthetic protein FliP [Polar flagella (CVF786)] [Aeromonas veronii B565]

428

gene76

VFG038673(gi:330828810)

(fliQ) flagellar biosynthetic protein FliQ [Polar flagella (CVF786)] [Aeromonas veronii B565]

1279

gene77

VFG038677(gi:330828811)

(fliR) flagellar biosynthetic protein fliR [Polar flagella (CVF786)] [Aeromonas veronii B565]

1980

gene78

VFG038681(gi:330828812)

(flhB) flagellar biosynthetic protein FlhB [Polar flagella (CVF786)] [Aeromonas veronii B565]

3613

gene79

VFG038685(gi:330828813)

(flhA) flagellar biosynthesis protein FlhA [Polar flagella (CVF786)] [Aeromonas veronii B565]

2511

gene80

VFG038689(gi:330828814)

(flhF) flagellar biosynthesis protein FlhF [Polar flagella (CVF786)] [Aeromonas veronii B565]

1543

gene81

VFG038693(gi:330828815)

(flhG) CobQ/CobB/MinD/ParA family protein [Polar flagella (CVF786)] [Aeromonas veronii B565]

1155

gene82

VFG038696(gi:145298363)

(fliA) flagellar biosynthesis sigma factor [Polar flagella (CVF786)] [Aeromonas salmonicida subsp. salmonicida A449]

640

gene83

VFG038701(gi:330828817)

(cheY) response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Polar flagella (CVF786)] [Aeromonas veronii B565]

1288

gene84

VFG038705(gi:330828818)

(cheZ) chemotaxis protein CheZ [Polar flagella (CVF786)] [Aeromonas veronii B565]

3752

gene85

VFG038709(gi:330828819)

(cheA-2) transducing histidine kinase [Polar flagella (CVF786)] [Aeromonas veronii B565]

1912

gene86

VFG038713(gi:330828820)

(cheB-2) two component system response-regulator/protein-glutamate methylesterase CheB [Polar flagella (CVF786)] [Aeromonas veronii B565]

1236

gene87

VFG038717(gi:330828821)

(pomA) MotA/TolQ/ExbB proton channel [Polar flagella (CVF786)] [Aeromonas veronii B565]

1572

gene88

VFG038721(gi:330828822)

(pomB) OmpA family protein [Polar flagella (CVF786)] [Aeromonas veronii B565]

1401

gene89

VFG038725(gi:330828823)

(B565_1123) CobQ/CobB/MinD/ParA family protein [Polar flagella (CVF786)] [Aeromonas veronii B565]

1476

gene90

VFG038729(gi:330828824)

(cheW) CheW domain-containing protein [Polar flagella (CVF786)] [Aeromonas veronii B565]

823

gene91

VFG043204(gb|YP_855930)

(cheW-2) chemotaxis protein CheW [ND (AI144)] [Aeromonas hydrophila subsp. hydrophila ATCC 7966]

816

gene192

VFG013171(gi:170719013)

(gmhA/lpcA) phosphoheptose isomerase [LOS (CVF494)] [Haemophilus somnus 2336]

1956

gene353

VFG038474(gi:330829098)

(tapW) Tfp pilus assembly protein, ATPase PilU [Tap type IV pili (CVF783)] [Aeromonas veronii B565]

1347

gene406

VFG038732(gi:145299590)

(flaA) flagellin A [Polar flagella (CVF786)] [Aeromonas salmonicida subsp. salmonicida A449]

1386

gene407

VFG038734(gb|YP_856235)

(flaB) flagellin [ND (AI144)] [Aeromonas hydrophila subsp. hydrophila ATCC 7966]

582

gene408

VFG038741(gi:145299588)

(flaG) flagellar protein FlaG [Polar flagella (CVF786)] [Aeromonas salmonicida subsp. salmonicida A449]

2162

gene409

VFG038742(gb|YP_856237)

(flaH) flagellar hook-associated protein 2 [ND (AI144)] [Aeromonas hydrophila subsp. hydrophila ATCC 7966]

674

gene410

VFG038748(gi:145299586)

(flaJ) flagellar protein FliS [Polar flagella (CVF786)] [Aeromonas salmonicida subsp. salmonicida A449]

2868

gene411

VFG038750(gb|YP_856239)

(maf-1) putative flagellin glycosyltransferase [ND (AI144)] [Aeromonas hydrophila subsp. hydrophila ATCC 7966]

1746

gene419

VFG038850(gb|YP_858603)

(nueB) pseudaminic acid synthase, NeuB [Polar flagella (CVF786)] [Aeromonas hydrophila subsp. hydrophila ATCC 7966]

1724

gene420

VFG038847(gb|YP_858602)

(flmD) FlmD protein [Polar flagella (CVF786)] [Aeromonas hydrophila subsp. hydrophila ATCC 7966]

1104

gene421

VFG038844(gb|YP_858601)

(nueA) NeuA protein [Polar flagella (CVF786)] [Aeromonas hydrophila subsp. hydrophila ATCC 7966]

595

gene422

VFG038843(gi:145297256)

(flmH) flagellar modification protein FlmH [Polar flagella (CVF786)] [Aeromonas salmonicida subsp. salmonicida A449]

1142

gene424

VFG038841(gi:145297258)

(flmH) 3-oxoacyl-ACP reductase [Polar flagella (CVF786)] [Aeromonas salmonicida subsp. salmonicida A449]

1285

gene747

VFG038315(gi:330830600)

(exeN) general secretion pathway protein N [T2SS (CVF780)] [Aeromonas veronii B565]

823

gene748

VFG038311(gi:330830599)

(exeM) general secretion pathway protein M [T2SS (CVF780)] [Aeromonas veronii B565]

2014

gene749

VFG038307(gi:330830598)

(exeL) general secretion pathway protein L [T2SS (CVF780)] [Aeromonas veronii B565]

1728

gene750

VFG038303(gi:330830597)

(exeK) general secretion pathway protein K [T2SS (CVF780)] [Aeromonas veronii B565]

1116

gene751

VFG038299(gi:330830596)

(exeJ) general secretion pathway protein J [T2SS (CVF780)] [Aeromonas veronii B565]

605

gene752

VFG038295(gi:330830595)

(exeI) general secretion pathway protein I [T2SS (CVF780)] [Aeromonas veronii B565]

968

gene753

VFG038291(gi:330830594)

(exeH) general secretion pathway protein H [T2SS (CVF780)] [Aeromonas veronii B565]

744

gene754

VFG038287(gi:330830593)

(exeG) Pullulanase G protein [T2SS (CVF780)] [Aeromonas veronii B565]

2123

gene755

VFG038283(gi:330830592)

(exeF) general secretion pathway protein F [T2SS (CVF780)] [Aeromonas veronii B565]

2599

gene756

VFG038279(gi:330830591)

(exeE) type II secretory pathway, ATPase PulE-like protein [T2SS (CVF780)] [Aeromonas veronii B565]

3545

gene757

VFG038275(gi:330830590)

(exeD) general secretion pathway protein D [T2SS (CVF780)] [Aeromonas veronii B565]

1435

gene758

VFG038271(gi:330830589)

(exeC) general secretion pathway protein C [T2SS (CVF780)] [Aeromonas veronii B565]

1163

gene760

VFG038267(gi:330830588)

(exeB) general secretion pathway protein B [T2SS (CVF780)] [Aeromonas veronii B565]

2752

gene761

VFG038263(gi:330830587)

(exeA) general secretion pathway protein A [T2SS (CVF780)] [Aeromonas veronii B565]

3880

gene853

VFG049139

(acrB) acriflavine resistance protein B [AcrAB (CVF859)] [Klebsiella pneumoniae 342]

1457

gene854

VFG007659(gi:59710773)

(rmlB) dTDP-glucose 4,6-dehydratase [Capsular polysaccharide (CVF282)] [Vibrio fischeri ES114]

1112

gene856

VFG018664(gi:157151373)

(rfbA-1) glucose-1-phosphate thymidylyltransferase [Capsule (CVF186)] [Streptococcus gordonii str. Challis substr. CH1]

1450

gene869

VFG007659(gi:59710773)

(rmlB) dTDP-glucose 4,6-dehydratase [Capsular polysaccharide (CVF282)] [Vibrio fischeri ES114]

1129

gene871

VFG005997(gi:24379858)

(rmlA) putative glucose-1-phosphate thymidyltransferase [Capsule (CVF186)] [Streptococcus mutans UA159]

1613

gene883

VFG048789

(A225_3877) UDP-glucose dehydrogenase [Capsule (CVF854)] [Klebsiella oxytoca E718]

1255

gene977

VFG038507(gi:330830070)

(tapF) type IV pilus biogenesis/stability protein PilW [Tap type IV pili (CVF783)] [Aeromonas veronii B565]

1384

gene1009

VFG038833(gi:145298724)

(pomB2) flagellar motor protein MotB [Polar flagella (CVF786)] [Aeromonas salmonicida subsp. salmonicida A449]

179

gene1060

VFG041500(gi:292487028)

(orfU1) hypothetical protein [T3SS (SS004)] [Erwinia amylovora CFBP1430]

1615

gene1313

VFG013517(gi:113460873)

(mrsA/glmM) phosphoglucosamine mutase [Exopolysaccharide (CVF495)] [Haemophilus somnus 129PT]

1474

gene1320

VFG038834(gi:330830900)

(pomB2) sodium-driven polar flagellar protein [Polar flagella (CVF786)] [Aeromonas veronii B565]

1287

gene1321

VFG038838(gi:330830901)

(pomA2) chemotaxis protein PomA [Polar flagella (CVF786)] [Aeromonas veronii B565]

1237

gene1500

VFG038845(gi:507522470)

(nueA) flagellar-related 3-deoxy-D-manno-octulosonate cytidylyltransferase [Polar flagella (VF0473)] [Aeromonas hydrophila ML09-119]

1444

gene1557

VFG038754(gi:145299432)

(motY) sodium-type polar flagellum motor protein [Polar flagella (CVF786)] [Aeromonas salmonicida subsp. salmonicida A449]

2315

gene1585

VFG038903(gi:330830274)

(hlyA) putative transporter [Hemolysin HlyA (CVF792)] [Aeromonas veronii B565]

2340

gene1600

VFG038758(gi:330830288)

(flrC) Fis family two component sigma54 specific transcriptional regulator [Polar flagella (CVF786)] [Aeromonas veronii B565]

1792

gene1601

VFG038762(gi:330830289)

(flrB) two component system flagellar sensor histidine kinase FlrB [Polar flagella (CVF786)] [Aeromonas veronii B565]

2449

gene1602

VFG038766(gi:330830290)

(flrA) FleQ protein [Polar flagella (CVF786)] [Aeromonas veronii B565]

2025

gene1608

VFG038770(gi:330830296)

(flgL) flagellar hook-associated protein 3 [Polar flagella (CVF786)] [Aeromonas veronii B565]

3404

gene1609

VFG038774(gi:330830297)

(flgK) flagellar hook-associated protein FlgK [Polar flagella (CVF786)] [Aeromonas veronii B565]

1891

gene1610

VFG038778(gi:330830298)

(flgJ) peptidoglycan hydrolase FlgJ [Polar flagella (CVF786)] [Aeromonas veronii B565]

1877

gene1611

VFG038782(gi:330830299)

(flgI) flagellar P-ring protein FlgI [Polar flagella (CVF786)] [Aeromonas veronii B565]

1148

gene1612

VFG038786(gi:330830300)

(flgH) flagellar L-ring protein [Polar flagella (CVF786)] [Aeromonas veronii B565]

1359

gene1613

VFG038790(gi:330830301)

(flgG) flagellar basal body rod protein FlgG [Polar flagella (CVF786)] [Aeromonas veronii B565]

1299

gene1614

VFG038794(gi:330830302)

(flgF) flagellar basal-body rod protein FlgF [Polar flagella (CVF786)] [Aeromonas veronii B565]

2067

gene1615

VFG038798(gi:330830303)

(flgE) flagellar hook protein FlgE [Polar flagella (CVF786)] [Aeromonas veronii B565]

954

gene1616

VFG038802(gi:330830304)

(flgD) flagellar hook capping protein [Polar flagella (CVF786)] [Aeromonas veronii B565]

727

gene1617

VFG038806(gi:330830305)

(flgC) flagellar basal-body rod protein FlgC [Polar flagella (CVF786)] [Aeromonas veronii B565]

699

gene1618

VFG038810(gi:330830306)

(flgB) flagellar basal-body rod protein FlgB [Polar flagella (CVF786)] [Aeromonas veronii B565]

1452

gene1620

VFG038814(gi:330830307)

(cheR-3) CheR methyltransferase [Polar flagella (CVF786)] [Aeromonas veronii B565]

1593

gene1621

VFG038818(gi:330830308)

(cheV) chemotaxis protein methyltransferase CheV [Polar flagella (CVF786)] [Aeromonas veronii B565]

1164

gene1622

VFG038822(gi:330830309)

(flgA) flagellar basal body P-ring biosynthesis protein FlgA [Polar flagella (CVF786)] [Aeromonas veronii B565]

525

gene1623

VFG038826(gi:330830310)

(flgM) anti-sigma-D factor [Polar flagella (CVF786)] [Aeromonas veronii B565]

609

gene1624

VFG038830(gi:330830311)

(flgN) flagellar biosynthetic protein FlgN [Polar flagella (CVF786)] [Aeromonas veronii B565]

631

gene1678

VFG000478(gi:16764063)

(fur) transcriptional repressor of iron-responsive genes (Fur family) (ferric uptake regulator) [Fur (VF0113)] [Salmonella enterica subsp. enterica serovar Typhimurium str. LT2]

1213

gene1720

VFG013465(gb|NP_439706)

(kdsA) 2-dehydro-3-deoxyphosphooctonate aldolase [LOS (CVF494)] [Haemophilus influenzae Rd KW20]

3809

gene1756

VFG038462(gi:330828668)

(tapQ) type IV pilus secretin PilQ [Tap type IV pili (CVF783)] [Aeromonas veronii B565]

932

gene1757

VFG038458(gi:330828667)

(tapP) type IV pilus biogenesis protein PilP [Tap type IV pili (CVF783)] [Aeromonas veronii B565]

1054

gene1758

VFG038454(gi:330828666)

(tapO) type IV pilus biogenesis protein PilO [Tap type IV pili (CVF783)] [Aeromonas veronii B565]

986

gene1759

VFG038450(gi:330828665)

(tapN) type IV pilus biogenesis PilN [Tap type IV pili (CVF783)] [Aeromonas veronii B565]

1837

gene1760

VFG038446(gi:330828664)

(tapM) type IV pilus biogenesis protein PilM [Tap type IV pili (CVF783)] [Aeromonas veronii B565]

1158

gene1786

VFG038911(gi:330828638)

(B565_0938) Thermostable hemolysin [Thermostable hemolysin (TH) (CVF794)] [Aeromonas veronii B565]

3032

gene1881

VFG044242(gi:145300215)

(hutA) outer-membrane heme receptor [direct heme uptake system (IA062)] [Aeromonas salmonicida subsp. salmonicida A449]

1230

gene1882

VFG044243(gi:145300216)

(ASA_3329) iron-regulated protein [direct heme uptake system (IA062)] [Aeromonas salmonicida subsp. salmonicida A449]

696

gene1883

VFG044244(gi:145300217)

(ASA_3330) isochorismatase family protein [direct heme uptake system (IA062)] [Aeromonas salmonicida subsp. salmonicida A449]

919

gene1885

VFG044246(gi:145300219)

(hutZ) heme iron utilization protein [direct heme uptake system (IA062)] [Aeromonas salmonicida subsp. salmonicida A449]

789

gene1886

VFG044247(gi:145300220)

(hutX) heme iron utilization protein [direct heme uptake system (IA062)] [Aeromonas salmonicida subsp. salmonicida A449]

1067

gene1887

VFG044248(gi:145300221)

(hutB) ABC-type hemin transporter, periplasmic component [direct heme uptake system (IA062)] [Aeromonas salmonicida subsp. salmonicida A449]

1175

gene1888

VFG044249(gi:145300222)

(hutC) ABC-type hemin transporter, permease protein [direct heme uptake system (IA062)] [Aeromonas salmonicida subsp. salmonicida A449]

1137

gene1889

VFG044250(gi:145300223)

(hutD) ABC-type hemin transporter, ATP-binding protein [direct heme uptake system (IA062)] [Aeromonas salmonicida subsp. salmonicida A449]

2036

gene1925

VFG010484(gi:54296712)

(htpB) 60 kDa chaperonin (Protein Cpn60)(groEL protein)(Heat shock protein B). [Hsp60 (CVF347)] [Legionella pneumophila str. Paris]

3476

gene1981

VFG042801(gi:145300516)

(tapZ) type IV pilus assembly TapZ [Tap pili (AI103)] [Aeromonas salmonicida subsp. salmonicida A449]

715

gene1994

VFG018241(gb|NP_230208)

(luxS) S-ribosylhomocysteinase [AI-2 (VF0406)] [Vibrio cholerae O1 biovar El Tor str. N16961]

569

gene2004

VFG038477(gi:145297758)

(tppA) type IV pilus assembly protein [Tap type IV pili (CVF783)] [Aeromonas salmonicida subsp. salmonicida A449]

1072

gene2031

VFG038621(gi:330831196)

(motX) sodium-type flagellar motor component [Polar flagella (CVF786)] [Aeromonas veronii B565]

1940

gene2047

VFG038470(gi:330831212)

(tapU) Twitching motility protein PilU [Tap type IV pili (CVF783)] [Aeromonas veronii B565]

1811

gene2048

VFG038466(gi:330831213)

(tapT) Pilus retraction ATPase PilT [Tap type IV pili (CVF783)] [Aeromonas veronii B565]

2993

gene2536

VFG038434(gi:330828059)

(tapB) type IV-A pilus assembly ATPase PilB [Tap type IV pili (CVF783)] [Aeromonas veronii B565]

2173

gene2537

VFG038438(gi:330828058)

(tapC) type IV pilus assembly protein tapC [Tap type IV pili (CVF783)] [Aeromonas veronii B565]

1444

gene2538

VFG038319(gi:330828057)

(tapD) N-methyltransferase [T2SS (CVF780)] [Aeromonas veronii B565]

1389

gene2998

VFG038616(gi:145300806)

(mshI) MSHA biogenesis protein MshI [Mannose-sensitive hemagglutinin (Msh) pilus, type IV pili (CVF785)] [Aeromonas salmonicida subsp. salmonicida A449]

998

gene2999

VFG038613(gi:330831369)

(mshI1) MSHA biogenesis protein MshI1 [Mannose-sensitive hemagglutinin (Msh) pilus, type IV pili (CVF785)] [Aeromonas veronii B565]

1108

gene3000

VFG038609(gi:330831368)

(mshJ) MSHA biogenesis protein MshJ [Mannose-sensitive hemagglutinin (Msh) pilus, type IV pili (CVF785)] [Aeromonas veronii B565]

550

gene3001

VFG038605(gi:330831367)

(mshK) MSHA biogenesis protein MshK [Mannose-sensitive hemagglutinin (Msh) pilus, type IV pili (CVF785)] [Aeromonas veronii B565]

2941

gene3002

VFG038602(gi:330831366)

(mshL) MSHA biogenesis protein MshL [Mannose-sensitive hemagglutinin (Msh) pilus, type IV pili (CVF785)] [Aeromonas veronii B565]

1509

gene3003

VFG038598(gi:330831365)

(mshM) general secretion pathway protein A [Mannose-sensitive hemagglutinin (Msh) pilus, type IV pili (CVF785)] [Aeromonas veronii B565]

1788

gene3004

VFG038594(gi:330831364)

(mshN) hypothetical protein [Mannose-sensitive hemagglutinin (Msh) pilus, type IV pili (CVF785)] [Aeromonas veronii B565]

2970

gene3005

VFG038591(gi:330831363)

(mshE) type IV pilin [Mannose-sensitive hemagglutinin (Msh) pilus, type IV pili (CVF785)] [Aeromonas veronii B565]

2100

gene3006

VFG038588(gi:330831362)

(mshG) GspF family protein [Mannose-sensitive hemagglutinin (Msh) pilus, type IV pili (CVF785)] [Aeromonas veronii B565]

773

gene3007

VFG038585(gi:330831361)

(mshF) hypothetical protein [Mannose-sensitive hemagglutinin (Msh) pilus, type IV pili (CVF785)] [Aeromonas veronii B565]

1148

gene3008

VFG038582(gi:330831360)

(mshA) Msha pilin protein mshb [Mannose-sensitive hemagglutinin (Msh) pilus, type IV pili (CVF785)] [Aeromonas veronii B565]

807

gene3010

VFG038577(gi:330831358)

(mshC) Msha pilin protein mshc [Mannose-sensitive hemagglutinin (Msh) pilus, type IV pili (CVF785)] [Aeromonas veronii B565]

944

gene3011

VFG038574(gi:330831357)

(mshD) MSHA biogenesis protein MshN/MshD [Mannose-sensitive hemagglutinin (Msh) pilus, type IV pili (CVF785)] [Aeromonas veronii B565]

1455

gene3012

VFG038569(gi:145300799)

(mshO) MSHA biogenesis protein MshO [Mannose-sensitive hemagglutinin (Msh) pilus, type IV pili (CVF785)] [Aeromonas salmonicida subsp. salmonicida A449]

694

gene3013

VFG038565(gi:145300798)

(mshP) MSHA biogenesis protein MshP [Mannose-sensitive hemagglutinin (Msh) pilus, type IV pili (CVF785)] [Aeromonas salmonicida subsp. salmonicida A449]

2599

gene3042

VFG044038(gi:116042150)

(ABJ52834) aerolysin [aerolysin (TX454)] [Aeromonas veronii (Aeromonas ichthiosmia) str. MTCC 3249]

239

gene3074

VFG010907(gi:54296805)

(csrA) global regulator CsrA [Carbon storage regulator A (CVF362)] [Legionella pneumophila str. Paris]

1272

gene3228

VFG013286(gb|NP_438515)

(galE) UDP-glucose 4-epimerase [LOS (CVF494)] [Haemophilus influenzae Rd KW20]

1257

gene3272

VFG000477(gi:16766230)

(rpoS) sigma S (sigma 38) factor of RNA polymerase, major sigmafactor during stationary phase [RpoS (VF0112)] [Salmonella enterica subsp. enterica serovar Typhimurium str. LT2]

2900

gene3460

VFG001862(gb|YP_096397)

(katB) catalase-peroxidase KatB [KatAB (VF0168)] [Legionella pneumophila subsp. pneumophila str. Philadelphia 1]

1400

gene3502

VFG013197(gi:170717931)

(hemB) Porphobilinogen synthase [Heme biosynthesis (CVF506)] [Haemophilus somnus 2336]

3519

gene3645

VFG049190

(KOX_00005) protein disaggregation chaperone [T6SS-II (CVF861)] [Klebsiella oxytoca KCTC 1686]

284

gene3679

VFG046474

(OOM_0626) elongation factor [EF-Tu (CVF827)] [Francisella noatunensis subsp. orientalis str. Toba 04]

3646

gene3706

VFG038503(gi:330829260)

(tapV) Motility protein FimV [Tap type IV pili (CVF783)] [Aeromonas veronii B565]

1513

gene3744

VFG013612(gi:113461676)

(hemE) uroporphyrinogen decarboxylase [Heme biosynthesis (CVF506)] [Haemophilus somnus 129PT]

1027

gene3776

VFG038907(gi:330828499)

(B565_0799) Hemolysin III [Hemolysin III (CVF793)] [Aeromonas veronii B565]

2264

gene3861

VFG013532(gi:148826097)

(pgi) glucose-6-phosphate isomerase [Exopolysaccharide (CVF495)] [Haemophilus influenzae PittEE]

191

gene3959

VFG046459

(Fphi_1039) elongation factor Tu [EF-Tu (CVF827)] [Francisella philomiragia subsp. philomiragia ATCC 25017]

284

gene3976

VFG046474

(OOM_0626) elongation factor [EF-Tu (CVF827)] [Francisella noatunensis subsp. orientalis str. Toba 04]

1230

gene3984

VFG038840(gi:507521851)

(flmH) flagellar-related 3-oxoacyl-ACP reductase [Polar flagella (VF0473)] [Aeromonas hydrophila ML09-119]

191

gene4005

VFG046459

(Fphi_1039) elongation factor Tu [EF-Tu (CVF827)] [Francisella philomiragia subsp. philomiragia ATCC 25017]

756

gene4007

VFG016491(gi:26553484)

(tuf) elongation factor Tu [EF-Tu (CVF587)] [Mycoplasma penetrans HF-2]

Table S8. Genome annotation by VFDB(A16)

Score

Query-Name

Hit-Name

Description

1049

gene22

VFG038841(gi:145297258)

(flmH) 3-oxoacyl-ACP reductase [Polar flagella (CVF786)] [Aeromonas salmonicida subsp. salmonicida A449]

1106

gene25

VFG038844(gb|YP_858601)

(nueA) NeuA protein [Polar flagella (CVF786)] [Aeromonas hydrophila subsp. hydrophila ATCC 7966]

1732

gene26

VFG038847(gb|YP_858602)

(flmD) FlmD protein [Polar flagella (CVF786)] [Aeromonas hydrophila subsp. hydrophila ATCC 7966]

1722

gene27

VFG038850(gb|YP_858603)

(nueB) pseudaminic acid synthase, NeuB [Polar flagella (CVF786)] [Aeromonas hydrophila subsp. hydrophila ATCC 7966]

2804

gene35

VFG038750(gb|YP_856239)

(maf-1) putative flagellin glycosyltransferase [ND (AI144)] [Aeromonas hydrophila subsp. hydrophila ATCC 7966]

682

gene36

VFG038748(gi:145299586)

(flaJ) flagellar protein FliS [Polar flagella (CVF786)] [Aeromonas salmonicida subsp. salmonicida A449]

2250

gene37

VFG038742(gb|YP_856237)

(flaH) flagellar hook-associated protein 2 [ND (AI144)] [Aeromonas hydrophila subsp. hydrophila ATCC 7966]

583

gene38

VFG038741(gi:145299588)

(flaG) flagellar protein FlaG [Polar flagella (CVF786)] [Aeromonas salmonicida subsp. salmonicida A449]

1408

gene39

VFG038734(gb|YP_856235)

(flaB) flagellin [ND (AI144)] [Aeromonas hydrophila subsp. hydrophila ATCC 7966]

1425

gene40

VFG038730(gb|YP_856234)

(flaA) flagellin [ND (AI144)] [Aeromonas hydrophila subsp. hydrophila ATCC 7966]

1964

gene92

VFG038474(gi:330829098)

(tapW) Tfp pilus assembly protein, ATPase PilU [Tap type IV pili (CVF783)] [Aeromonas veronii B565]

823

gene251

VFG013171(gi:170719013)

(gmhA/lpcA) phosphoheptose isomerase [LOS (CVF494)] [Haemophilus somnus 2336]

1227

gene461

VFG038838(gi:330830901)

(pomA2) chemotaxis protein PomA [Polar flagella (CVF786)] [Aeromonas veronii B565]

1448

gene462

VFG038834(gi:330830900)

(pomB2) sodium-driven polar flagellar protein [Polar flagella (CVF786)] [Aeromonas veronii B565]

1615

gene469

VFG013517(gi:113460873)

(mrsA/glmM) phosphoglucosamine mutase [Exopolysaccharide (CVF495)] [Haemophilus somnus 129PT]

2747

gene845

VFG038263(gi:330830587)

(exeA) general secretion pathway protein A [T2SS (CVF780)] [Aeromonas veronii B565]

1144

gene846

VFG038267(gi:330830588)

(exeB) general secretion pathway protein B [T2SS (CVF780)] [Aeromonas veronii B565]

1434

gene847

VFG038271(gi:330830589)

(exeC) general secretion pathway protein C [T2SS (CVF780)] [Aeromonas veronii B565]

3518

gene848

VFG038275(gi:330830590)

(exeD) general secretion pathway protein D [T2SS (CVF780)] [Aeromonas veronii B565]

2595

gene849

VFG038279(gi:330830591)

(exeE) type II secretory pathway, ATPase PulE-like protein [T2SS (CVF780)] [Aeromonas veronii B565]

2123

gene850

VFG038283(gi:330830592)

(exeF) general secretion pathway protein F [T2SS (CVF780)] [Aeromonas veronii B565]

744

gene851

VFG038287(gi:330830593)

(exeG) Pullulanase G protein [T2SS (CVF780)] [Aeromonas veronii B565]

973

gene852

VFG038291(gi:330830594)

(exeH) general secretion pathway protein H [T2SS (CVF780)] [Aeromonas veronii B565]

618

gene853

VFG038295(gi:330830595)

(exeI) general secretion pathway protein I [T2SS (CVF780)] [Aeromonas veronii B565]

1120

gene854

VFG038299(gi:330830596)

(exeJ) general secretion pathway protein J [T2SS (CVF780)] [Aeromonas veronii B565]

1729

gene855

VFG038303(gi:330830597)

(exeK) general secretion pathway protein K [T2SS (CVF780)] [Aeromonas veronii B565]

1990

gene856

VFG038307(gi:330830598)

(exeL) general secretion pathway protein L [T2SS (CVF780)] [Aeromonas veronii B565]

821

gene857

VFG038311(gi:330830599)

(exeM) general secretion pathway protein M [T2SS (CVF780)] [Aeromonas veronii B565]

1285

gene858

VFG038315(gi:330830600)

(exeN) general secretion pathway protein N [T2SS (CVF780)] [Aeromonas veronii B565]

1441

gene987

VFG038754(gi:145299432)

(motY) sodium-type polar flagellum motor protein [Polar flagella (CVF786)] [Aeromonas salmonicida subsp. salmonicida A449]

2315

gene1016

VFG038903(gi:330830274)

(hlyA) putative transporter [Hemolysin HlyA (CVF792)] [Aeromonas veronii B565]

2327

gene1032

VFG038758(gi:330830288)

(flrC) Fis family two component sigma54 specific transcriptional regulator [Polar flagella (CVF786)] [Aeromonas veronii B565]

1792

gene1033

VFG038762(gi:330830289)

(flrB) two component system flagellar sensor histidine kinase FlrB [Polar flagella (CVF786)] [Aeromonas veronii B565]

2447

gene1034

VFG038766(gi:330830290)

(flrA) FleQ protein [Polar flagella (CVF786)] [Aeromonas veronii B565]

1992

gene1040

VFG038770(gi:330830296)

(flgL) flagellar hook-associated protein 3 [Polar flagella (CVF786)] [Aeromonas veronii B565]

3412

gene1041

VFG038774(gi:330830297)

(flgK) flagellar hook-associated protein FlgK [Polar flagella (CVF786)] [Aeromonas veronii B565]

1889

gene1042

VFG038778(gi:330830298)

(flgJ) peptidoglycan hydrolase FlgJ [Polar flagella (CVF786)] [Aeromonas veronii B565]

1877

gene1043

VFG038782(gi:330830299)

(flgI) flagellar P-ring protein FlgI [Polar flagella (CVF786)] [Aeromonas veronii B565]

1166

gene1044

VFG038786(gi:330830300)

(flgH) flagellar L-ring protein [Polar flagella (CVF786)] [Aeromonas veronii B565]

1359

gene1045

VFG038790(gi:330830301)

(flgG) flagellar basal body rod protein FlgG [Polar flagella (CVF786)] [Aeromonas veronii B565]

1299

gene1046

VFG038794(gi:330830302)

(flgF) flagellar basal-body rod protein FlgF [Polar flagella (CVF786)] [Aeromonas veronii B565]

2067

gene1047

VFG038798(gi:330830303)

(flgE) flagellar hook protein FlgE [Polar flagella (CVF786)] [Aeromonas veronii B565]

954

gene1048

VFG038802(gi:330830304)

(flgD) flagellar hook capping protein [Polar flagella (CVF786)] [Aeromonas veronii B565]

727

gene1049

VFG038806(gi:330830305)

(flgC) flagellar basal-body rod protein FlgC [Polar flagella (CVF786)] [Aeromonas veronii B565]

695

gene1050

VFG038810(gi:330830306)

(flgB) flagellar basal-body rod protein FlgB [Polar flagella (CVF786)] [Aeromonas veronii B565]

1452

gene1051

VFG038814(gi:330830307)

(cheR-3) CheR methyltransferase [Polar flagella (CVF786)] [Aeromonas veronii B565]

1593

gene1052

VFG038818(gi:330830308)

(cheV) chemotaxis protein methyltransferase CheV [Polar flagella (CVF786)] [Aeromonas veronii B565]

1174

gene1053

VFG038822(gi:330830309)

(flgA) flagellar basal body P-ring biosynthesis protein FlgA [Polar flagella (CVF786)] [Aeromonas veronii B565]

525

gene1054

VFG038826(gi:330830310)

(flgM) anti-sigma-D factor [Polar flagella (CVF786)] [Aeromonas veronii B565]

609

gene1055

VFG038830(gi:330830311)

(flgN) flagellar biosynthetic protein FlgN [Polar flagella (CVF786)] [Aeromonas veronii B565]

631

gene1109

VFG000478(gi:16764063)

(fur) transcriptional repressor of iron-responsive genes (Fur family) (ferric uptake regulator) [Fur (VF0113)] [Salmonella enterica subsp. enterica serovar Typhimurium str. LT2]

1809

gene1291

VFG038466(gi:330831213)

(tapT) Pilus retraction ATPase PilT [Tap type IV pili (CVF783)] [Aeromonas veronii B565]

1847

gene1292

VFG038470(gi:330831212)

(tapU) Twitching motility protein PilU [Tap type IV pili (CVF783)] [Aeromonas veronii B565]

1082

gene1308

VFG038621(gi:330831196)

(motX) sodium-type flagellar motor component [Polar flagella (CVF786)] [Aeromonas veronii B565]

681

gene1335

VFG038478(gi:330831169)

(tppA) TppA protein [Tap type IV pili (CVF783)] [Aeromonas veronii B565]

972

gene1336

VFG038482(gi:330831168)

(tppB) type IV pilus assembly protein [Tap type IV pili (CVF783)] [Aeromonas veronii B565]

1481

gene1337

VFG038484(gi:330831167)

(tppC) TppC protein [Tap type IV pili (CVF783)] [Aeromonas veronii B565]

645

gene1338

VFG038486(gi:330831166)

(tppD) hypothetical protein [Tap type IV pili (CVF783)] [Aeromonas veronii B565]

6266

gene1339

VFG038490(gi:330831165)

(tapY1) TapY1 protein [Tap type IV pili (CVF783)] [Aeromonas veronii B565]

463

gene1340

VFG038491(gi:330831164)

(tapY2) TapY2 protein [Tap type IV pili (CVF783)] [Aeromonas veronii B565]

689

gene1342

VFG038495(gi:330831162)

(tppE) putative type IV pilus biogenesis protein [Tap type IV pili (CVF783)] [Aeromonas veronii B565]

715

gene1346

VFG018241(gb|NP_230208)

(luxS) S-ribosylhomocysteinase [AI-2 (VF0406)] [Vibrio cholerae O1 biovar El Tor str. N16961]

3478

gene1359

VFG042801(gi:145300516)

(tapZ) type IV pilus assembly TapZ [Tap pili (AI103)] [Aeromonas salmonicida subsp. salmonicida A449]

2035

gene1426

VFG010484(gi:54296712)

(htpB) 60 kDa chaperonin (Protein Cpn60)(groEL protein)(Heat shock protein B). [Hsp60 (CVF347)] [Legionella pneumophila str. Paris]

823

gene1475

VFG043204(gb|YP_855930)

(cheW-2) chemotaxis protein CheW [ND (AI144)] [Aeromonas hydrophila subsp. hydrophila ATCC 7966]

1501

gene1476

VFG038729(gi:330828824)

(cheW) CheW domain-containing protein [Polar flagella (CVF786)] [Aeromonas veronii B565]

1396

gene1477

VFG038725(gi:330828823)

(B565_1123) CobQ/CobB/MinD/ParA family protein [Polar flagella (CVF786)] [Aeromonas veronii B565]

1575

gene1478

VFG038721(gi:330828822)

(pomB) OmpA family protein [Polar flagella (CVF786)] [Aeromonas veronii B565]

1241

gene1479

VFG038717(gi:330828821)

(pomA) MotA/TolQ/ExbB proton channel [Polar flagella (CVF786)] [Aeromonas veronii B565]

1914

gene1480

VFG038713(gi:330828820)

(cheB-2) two component system response-regulator/protein-glutamate methylesterase CheB [Polar flagella (CVF786)] [Aeromonas veronii B565]

3748

gene1481

VFG038709(gi:330828819)

(cheA-2) transducing histidine kinase [Polar flagella (CVF786)] [Aeromonas veronii B565]

1288

gene1482

VFG038705(gi:330828818)

(cheZ) chemotaxis protein CheZ [Polar flagella (CVF786)] [Aeromonas veronii B565]

640

gene1483

VFG038701(gi:330828817)

(cheY) response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Polar flagella (CVF786)] [Aeromonas veronii B565]

1156

gene1484

VFG038696(gi:145298363)

(fliA) flagellar biosynthesis sigma factor [Polar flagella (CVF786)] [Aeromonas salmonicida subsp. salmonicida A449]

1543

gene1485

VFG038693(gi:330828815)

(flhG) CobQ/CobB/MinD/ParA family protein [Polar flagella (CVF786)] [Aeromonas veronii B565]

2511

gene1486

VFG038689(gi:330828814)

(flhF) flagellar biosynthesis protein FlhF [Polar flagella (CVF786)] [Aeromonas veronii B565]

3606

gene1487

VFG038685(gi:330828813)

(flhA) flagellar biosynthesis protein FlhA [Polar flagella (CVF786)] [Aeromonas veronii B565]

1958

gene1488

VFG038681(gi:330828812)

(flhB) flagellar biosynthetic protein FlhB [Polar flagella (CVF786)] [Aeromonas veronii B565]

1272

gene1489

VFG038677(gi:330828811)

(fliR) flagellar biosynthetic protein fliR [Polar flagella (CVF786)] [Aeromonas veronii B565]

423

gene1490

VFG038672(gi:145298357)

(fliQ) flagellar biosynthetic protein FliQ [Polar flagella (CVF786)] [Aeromonas salmonicida subsp. salmonicida A449]

1140

gene1491

VFG038669(gi:330828809)

(fliP) flagellar biosynthetic protein FliP [Polar flagella (CVF786)] [Aeromonas veronii B565]

622

gene1492

VFG038665(gi:330828808)

(fliO) flagellar biosynthesis protein, FliO [Polar flagella (CVF786)] [Aeromonas veronii B565]

653

gene1493

VFG038661(gi:330828807)

(fliN) flagellar motor switch phosphatase FliY [Polar flagella (CVF786)] [Aeromonas veronii B565]

1852

gene1494

VFG038657(gi:330828806)

(fliM) flagellar motor switch protein FliM [Polar flagella (CVF786)] [Aeromonas veronii B565]

857

gene1495

VFG038653(gi:330828805)

(fliL) flagellar basal body-associated protein FliL [Polar flagella (CVF786)] [Aeromonas veronii B565]

2662

gene1496

VFG038649(gi:330828804)

(fliK) putative polar flagellar hook-length control protein FliK [Polar flagella (CVF786)] [Aeromonas veronii B565]

736

gene1497

VFG038645(gi:330828803)

(fliJ) flagellar protein FliJ [Polar flagella (CVF786)] [Aeromonas veronii B565]

2288

gene1498

VFG038641(gi:330828802)

(fliI) flagellar protein export ATPase FliI [Polar flagella (CVF786)] [Aeromonas veronii B565]

1378

gene1499

VFG038637(gi:330828801)

(fliH) flagellar assembly protein FliH [Polar flagella (CVF786)] [Aeromonas veronii B565]

1823

gene1500

VFG038633(gi:330828800)

(fliG) flagellar motor switch protein FliG [Polar flagella (CVF786)] [Aeromonas veronii B565]

2973

gene1501

VFG038629(gi:330828799)

(fliF) flagellar M-ring protein FliF [Polar flagella (CVF786)] [Aeromonas veronii B565]

529

gene1502

VFG038624(gi:145298345)

(fliE) flagellar hook-basal body protein [Polar flagella (CVF786)] [Aeromonas salmonicida subsp. salmonicida A449]

1213

gene1584

VFG013465(gb|NP_439706)

(kdsA) 2-dehydro-3-deoxyphosphooctonate aldolase [LOS (CVF494)] [Haemophilus influenzae Rd KW20]

3824

gene1621

VFG038462(gi:330828668)

(tapQ) type IV pilus secretin PilQ [Tap type IV pili (CVF783)] [Aeromonas veronii B565]

936

gene1622

VFG038458(gi:330828667)

(tapP) type IV pilus biogenesis protein PilP [Tap type IV pili (CVF783)] [Aeromonas veronii B565]

1060

gene1623

VFG038454(gi:330828666)

(tapO) type IV pilus biogenesis protein PilO [Tap type IV pili (CVF783)] [Aeromonas veronii B565]

982

gene1624

VFG038450(gi:330828665)

(tapN) type IV pilus biogenesis PilN [Tap type IV pili (CVF783)] [Aeromonas veronii B565]

1834

gene1625

VFG038446(gi:330828664)

(tapM) type IV pilus biogenesis protein PilM [Tap type IV pili (CVF783)] [Aeromonas veronii B565]

1389

gene1812

VFG038833(gi:145298724)

(pomB2) flagellar motor protein MotB [Polar flagella (CVF786)] [Aeromonas salmonicida subsp. salmonicida A449]

1255

gene1844

VFG038507(gi:330830070)

(tapF) type IV pilus biogenesis/stability protein PilW [Tap type IV pili (CVF783)] [Aeromonas veronii B565]

1416

gene2063

VFG038319(gi:330828057)

(tapD) N-methyltransferase [T2SS (CVF780)] [Aeromonas veronii B565]

2130

gene2064

VFG038438(gi:330828058)

(tapC) type IV pilus assembly protein tapC [Tap type IV pili (CVF783)] [Aeromonas veronii B565]

2991

gene2065

VFG038434(gi:330828059)

(tapB) type IV-A pilus assembly ATPase PilB [Tap type IV pili (CVF783)] [Aeromonas veronii B565]

1117

gene2833

VFG038911(gi:330828638)

(B565_0938) Thermostable hemolysin [Thermostable hemolysin (TH) (CVF794)] [Aeromonas veronii B565]

1370

gene2962

VFG038617(gi:330831370)

(mshI) MSHA biogenesis protein MshI [Mannose-sensitive hemagglutinin (Msh) pilus, type IV pili (CVF785)] [Aeromonas veronii B565]

976

gene2963

VFG038613(gi:330831369)

(mshI1) MSHA biogenesis protein MshI1 [Mannose-sensitive hemagglutinin (Msh) pilus, type IV pili (CVF785)] [Aeromonas veronii B565]

1087

gene2964

VFG038609(gi:330831368)

(mshJ) MSHA biogenesis protein MshJ [Mannose-sensitive hemagglutinin (Msh) pilus, type IV pili (CVF785)] [Aeromonas veronii B565]

546

gene2965

VFG038605(gi:330831367)

(mshK) MSHA biogenesis protein MshK [Mannose-sensitive hemagglutinin (Msh) pilus, type IV pili (CVF785)] [Aeromonas veronii B565]

2511

gene2966

VFG038602(gi:330831366)

(mshL) MSHA biogenesis protein MshL [Mannose-sensitive hemagglutinin (Msh) pilus, type IV pili (CVF785)] [Aeromonas veronii B565]

1504

gene2967

VFG038598(gi:330831365)

(mshM) general secretion pathway protein A [Mannose-sensitive hemagglutinin (Msh) pilus, type IV pili (CVF785)] [Aeromonas veronii B565]

1768

gene2968

VFG038594(gi:330831364)

(mshN) hypothetical protein [Mannose-sensitive hemagglutinin (Msh) pilus, type IV pili (CVF785)] [Aeromonas veronii B565]

2950

gene2969

VFG038591(gi:330831363)

(mshE) type IV pilin [Mannose-sensitive hemagglutinin (Msh) pilus, type IV pili (CVF785)] [Aeromonas veronii B565]

2081

gene2970

VFG038588(gi:330831362)

(mshG) GspF family protein [Mannose-sensitive hemagglutinin (Msh) pilus, type IV pili (CVF785)] [Aeromonas veronii B565]

748

gene2971

VFG038585(gi:330831361)

(mshF) hypothetical protein [Mannose-sensitive hemagglutinin (Msh) pilus, type IV pili (CVF785)] [Aeromonas veronii B565]

1127

gene2972

VFG038582(gi:330831360)

(mshA) Msha pilin protein mshb [Mannose-sensitive hemagglutinin (Msh) pilus, type IV pili (CVF785)] [Aeromonas veronii B565]

801

gene2974

VFG038577(gi:330831358)

(mshC) Msha pilin protein mshc [Mannose-sensitive hemagglutinin (Msh) pilus, type IV pili (CVF785)] [Aeromonas veronii B565]

810

gene2975

VFG038574(gi:330831357)

(mshD) MSHA biogenesis protein MshN/MshD [Mannose-sensitive hemagglutinin (Msh) pilus, type IV pili (CVF785)] [Aeromonas veronii B565]

1506

gene2976

VFG038569(gi:145300799)

(mshO) MSHA biogenesis protein MshO [Mannose-sensitive hemagglutinin (Msh) pilus, type IV pili (CVF785)] [Aeromonas salmonicida subsp. salmonicida A449]

669

gene2977

VFG038565(gi:145300798)

(mshP) MSHA biogenesis protein MshP [Mannose-sensitive hemagglutinin (Msh) pilus, type IV pili (CVF785)] [Aeromonas salmonicida subsp. salmonicida A449]

2580

gene3004

VFG038894(gi:330831326)

(aerA/act) hemolysin Asa1 [Aerolysin AerA/Cytotoxic enterotoxin Act (CVF788)] [Aeromonas veronii B565]

3518

gene3040

VFG049190

(KOX_00005) protein disaggregation chaperone [T6SS-II (CVF861)] [Klebsiella oxytoca KCTC 1686]

1634

gene3074

VFG046474

(OOM_0626) elongation factor [EF-Tu (CVF827)] [Francisella noatunensis subsp. orientalis str. Toba 04]

1626

gene3091

VFG046474

(OOM_0626) elongation factor [EF-Tu (CVF827)] [Francisella noatunensis subsp. orientalis str. Toba 04]

1230

gene3177

VFG038840(gi:507521851)

(flmH) flagellar-related 3-oxoacyl-ACP reductase [Polar flagella (VF0473)] [Aeromonas hydrophila ML09-119]

3873

gene3262

VFG049139

(acrB) acriflavine resistance protein B [AcrAB (CVF859)] [Klebsiella pneumoniae 342]

1453

gene3263

VFG007659(gi:59710773)

(rmlB) dTDP-glucose 4,6-dehydratase [Capsular polysaccharide (CVF282)] [Vibrio fischeri ES114]

1129

gene3265

VFG005997(gi:24379858)

(rmlA) putative glucose-1-phosphate thymidyltransferase [Capsule (CVF186)] [Streptococcus mutans UA159]

696

gene3266

VFG048804

(KPHS_35550) dTDP-4-dehydrorhamnose 3,5-epimerase [Capsule (CVF854)] [Klebsiella pneumoniae subsp. pneumoniae HS11286]

1620

gene3282

VFG037905(gi:384141324)

(ABZJ_00078) putative nucleoside-diphosphate sugar epimerase [Capsule (CVF775)] [Acinetobacter baumannii MDR-ZJ06]

1399

gene3358

VFG013197(gi:170717931)

(hemB) Porphobilinogen synthase [Heme biosynthesis (CVF506)] [Haemophilus somnus 2336]

3659

gene3392

VFG038503(gi:330829260)

(tapV) Motility protein FimV [Tap type IV pili (CVF783)] [Aeromonas veronii B565]

1041

gene3416

VFG038907(gi:330828499)

(B565_0799) Hemolysin III [Hemolysin III (CVF793)] [Aeromonas veronii B565]

1521

gene3448

VFG013612(gi:113461676)

(hemE) uroporphyrinogen decarboxylase [Heme biosynthesis (CVF506)] [Haemophilus somnus 129PT]

1255

gene3541

VFG000477(gi:16766230)

(rpoS) sigma S (sigma 38) factor of RNA polymerase, major sigmafactor during stationary phase [RpoS (VF0112)] [Salmonella enterica subsp. enterica serovar Typhimurium str. LT2]

2259

gene3564

VFG013532(gi:148826097)

(pgi) glucose-6-phosphate isomerase [Exopolysaccharide (CVF495)] [Haemophilus influenzae PittEE]

2902

gene3624

VFG001862(gb|YP_096397)

(katB) catalase-peroxidase KatB [KatAB (VF0168)] [Legionella pneumophila subsp. pneumophila str. Philadelphia 1]

1122

gene3714

VFG044250(gi:145300223)

(hutD) ABC-type hemin transporter, ATP-binding protein [direct heme uptake system (IA062)] [Aeromonas salmonicida subsp. salmonicida A449]

1175

gene3715

VFG044249(gi:145300222)

(hutC) ABC-type hemin transporter, permease protein [direct heme uptake system (IA062)] [Aeromonas salmonicida subsp. salmonicida A449]

1065

gene3716

VFG044248(gi:145300221)

(hutB) ABC-type hemin transporter, periplasmic component [direct heme uptake system (IA062)] [Aeromonas salmonicida subsp. salmonicida A449]

786

gene3717

VFG044247(gi:145300220)

(hutX) heme iron utilization protein [direct heme uptake system (IA062)] [Aeromonas salmonicida subsp. salmonicida A449]

919

gene3718

VFG044246(gi:145300219)

(hutZ) heme iron utilization protein [direct heme uptake system (IA062)] [Aeromonas salmonicida subsp. salmonicida A449]

697

gene3720

VFG044244(gi:145300217)

(ASA_3330) isochorismatase family protein [direct heme uptake system (IA062)] [Aeromonas salmonicida subsp. salmonicida A449]

1234

gene3721

VFG044243(gi:145300216)

(ASA_3329) iron-regulated protein [direct heme uptake system (IA062)] [Aeromonas salmonicida subsp. salmonicida A449]

3039

gene3722

VFG044242(gi:145300215)

(hutA) outer-membrane heme receptor [direct heme uptake system (IA062)] [Aeromonas salmonicida subsp. salmonicida A449]

1239

gene3769

VFG038845(gi:507522470)

(nueA) flagellar-related 3-deoxy-D-manno-octulosonate cytidylyltransferase [Polar flagella (VF0473)] [Aeromonas hydrophila ML09-119]

239

gene3833

VFG010907(gi:54296805)

(csrA) global regulator CsrA [Carbon storage regulator A (CVF362)] [Legionella pneumophila str. Paris]

487

gene4034

VFG016491(gi:26553484)

(tuf) elongation factor Tu [EF-Tu (CVF587)] [Mycoplasma penetrans HF-2]

Table S9. Genome annotation by VFDB(A17)

Score Query-Name Hit-Name Description
1223 gene129 VFG038840(gi:507521851) (flmH) flagellar-related 3-oxoacyl-ACP reductase [Polar flagella (VF0473)] [Aeromonas hydrophila ML09-119]
1708 gene437 VFG044235(gb|YP_856993) (amoA) isochorismate synthases [amonabactin (IA020)] [Aeromonas hydrophila subsp. hydrophila ATCC 7966]
1439 gene537 VFG038833(gi:145298724) (pomB2) flagellar motor protein MotB [Polar flagella (CVF786)] [Aeromonas salmonicida subsp. salmonicida A449]
1327 gene566 VFG038504(gb|YP_856293) (tapF) type IV pilus biogenesis/stability protein, pilW-like [Tap type IV pili (CVF783)] [Aeromonas hydrophila subsp. hydrophila ATCC 7966]
2999 gene612 VFG038750(gb|YP_856239) (maf-1) putative flagellin glycosyltransferase [ND (AI144)] [Aeromonas hydrophila subsp. hydrophila ATCC 7966]
692 gene614 VFG038746(gb|YP_856238) (flaJ) flagellar specific chaperone FlaJ/FliS [ND (AI144)] [Aeromonas hydrophila subsp. hydrophila ATCC 7966]
2133 gene615 VFG038744(gi:145299587) (flaH) flagellar hook-associated protein 2 [Polar flagella (CVF786)] [Aeromonas salmonicida subsp. salmonicida A449]
611 gene616 VFG038741(gi:145299588) (flaG) flagellar protein FlaG [Polar flagella (CVF786)] [Aeromonas salmonicida subsp. salmonicida A449]
1380 gene617 VFG038734(gb|YP_856235) (flaB) flagellin [ND (AI144)] [Aeromonas hydrophila subsp. hydrophila ATCC 7966]
1332 gene618 VFG038732(gi:145299590) (flaA) flagellin A [Polar flagella (CVF786)] [Aeromonas salmonicida subsp. salmonicida A449]
821 gene765 VFG013171(gi:170719013) (gmhA/lpcA) phosphoheptose isomerase [LOS (CVF494)] [Haemophilus somnus 2336]
624 gene806 VFG000478(gi:16764063) (fur) transcriptional repressor of iron-responsive genes (Fur family) (ferric uptake regulator) [Fur (VF0113)] [Salmonella enterica subsp. enterica serovar Typhimurium str. LT2]
3040 gene824 VFG038899(gi:145299774) (ahh1) aerolysin B [Extracellular hemolysin AHH1 (CVF791)] [Aeromonas salmonicida subsp. salmonicida A449]
2368 gene880 VFG038508(gb|YP_856000) (flpL) Flp pilus pseudopilin [Flp type IV pili (CVF784)] [Aeromonas hydrophila subsp. hydrophila ATCC 7966]
835 gene881 VFG038512(gb|YP_855999) (flpK) Flp pilus pseudopilin [Flp type IV pili (CVF784)] [Aeromonas hydrophila subsp. hydrophila ATCC 7966]
719 gene882 VFG038516(gb|YP_855998) (flpJ) Flp pilus pseudopilin [Flp type IV pili (CVF784)] [Aeromonas hydrophila subsp. hydrophila ATCC 7966]
1268 gene883 VFG038520(gb|YP_855997) (flpI) Flp pilus assembly protein FlpI [Flp type IV pili (CVF784)] [Aeromonas hydrophila subsp. hydrophila ATCC 7966]
1480 gene884 VFG038524(gb|YP_855996) (flpH) Flp pilus assembly protein FlpH [Flp type IV pili (CVF784)] [Aeromonas hydrophila subsp. hydrophila ATCC 7966]
1460 gene885 VFG038528(gb|YP_855995) (flpG) Flp pilus assembly protein FlpG [Flp type IV pili (CVF784)] [Aeromonas hydrophila subsp. hydrophila ATCC 7966]
2233 gene886 VFG038532(gb|YP_855994) (flpF) traffic ATPase [Flp type IV pili (CVF784)] [Aeromonas hydrophila subsp. hydrophila ATCC 7966]
1885 gene887 VFG038537(gi:507521135) (flpE) type IVb pilus assembly protein [Flp type IV pili (VF0476)] [Aeromonas hydrophila ML09-119]
773 gene888 VFG038540(gb|YP_855992) (flpD) Flp pilus assembly protein FlpD [Flp type IV pili (CVF784)] [Aeromonas hydrophila subsp. hydrophila ATCC 7966]
2412 gene889 VFG038544(gb|YP_855991) (flpC) Flp pilus secretin FlpC [Flp type IV pili (CVF784)] [Aeromonas hydrophila subsp. hydrophila ATCC 7966]
1509 gene890 VFG038548(gb|YP_855990) (flpB) Flp pilus assembly protein [Flp type IV pili (CVF784)] [Aeromonas hydrophila subsp. hydrophila ATCC 7966]
657 gene891 VFG038553(gi:507521131) (flpA) type IVb pilus related protein [Flp type IV pili (VF0476)] [Aeromonas hydrophila ML09-119]
326 gene892 VFG038556(gb|YP_855988) (flp1) Flp pilus pilin subunit [Flp type IV pili (CVF784)] [Aeromonas hydrophila subsp. hydrophila ATCC 7966]
823 gene959 VFG043204(gb|YP_855930) (cheW-2) chemotaxis protein CheW [ND (AI144)] [Aeromonas hydrophila subsp. hydrophila ATCC 7966]
1316 gene960 VFG038728(gi:145298371) (cheW) hypothetical protein [Polar flagella (CVF786)] [Aeromonas salmonicida subsp. salmonicida A449]
1389 gene961 VFG038724(gi:145298370) (ASA_1361) SOJ-like and chromosome partitioning protein [Polar flagella (CVF786)] [Aeromonas salmonicida subsp. salmonicida A449]
1432 gene962 VFG038718(gb|YP_855927) (pomB) ompA family protein [ND (AI144)] [Aeromonas hydrophila subsp. hydrophila ATCC 7966]
1235 gene963 VFG038716(gi:145298368) (pomA) MotA/TolQ/ExbB proton channel [Polar flagella (CVF786)] [Aeromonas salmonicida subsp. salmonicida A449]
1883 gene964 VFG038712(gi:145298367) (cheB-2) chemotaxis-specific methylesterase [Polar flagella (CVF786)] [Aeromonas salmonicida subsp. salmonicida A449]
3315 gene965 VFG038708(gi:145298366) (cheA-2) two-component system chemotaxis sensor histidine kinase CheA [Polar flagella (CVF786)] [Aeromonas salmonicida subsp. salmonicida A449]
1265 gene966 VFG038702(gb|YP_855923) (cheZ) chemotaxis protein CheZ [ND (AI144)] [Aeromonas hydrophila subsp. hydrophila ATCC 7966]
639 gene967 VFG038698(gb|YP_855922) (cheY) chemotaxis protein CheY [ND (AI144)] [Aeromonas hydrophila subsp. hydrophila ATCC 7966]
1221 gene968 VFG038696(gi:145298363) (fliA) flagellar biosynthesis sigma factor [Polar flagella (CVF786)] [Aeromonas salmonicida subsp. salmonicida A449]
1532 gene969 VFG038691(gi:507521013) (flhG) flagellar-related protein [Polar flagella (VF0473)] [Aeromonas hydrophila ML09-119]
2415 gene970 VFG038688(gi:145298361) (flhF) flagellar biosynthesis protein FlhF [Polar flagella (CVF786)] [Aeromonas salmonicida subsp. salmonicida A449]
3558 gene971 VFG038684(gi:145298360) (flhA) flagellar biosynthesis protein FlhA [Polar flagella (CVF786)] [Aeromonas salmonicida subsp. salmonicida A449]
1882 gene972 VFG038679(gi:507521010) (flhB) flagellar biosynthetic protein FlhB [Polar flagella (VF0473)] [Aeromonas hydrophila ML09-119]
1311 gene973 VFG038676(gi:145298358) (fliR) flagellar biosynthesis protein FliR [Polar flagella (CVF786)] [Aeromonas salmonicida subsp. salmonicida A449]
445 gene974 VFG038670(gb|YP_855915) (fliQ) flagellar biosynthetic protein FliQ [ND (AI144)] [Aeromonas hydrophila subsp. hydrophila ATCC 7966]
1206 gene975 VFG038668(gi:145298356) (fliP) flagellar biosynthesis protein FliP [Polar flagella (CVF786)] [Aeromonas salmonicida subsp. salmonicida A449]
609 gene976 VFG038662(gb|YP_855913) (fliO) flagellar biosynthesis protein, FliO [ND (AI144)] [Aeromonas hydrophila subsp. hydrophila ATCC 7966]
641 gene977 VFG038658(gb|YP_855912) (fliN) flagellar motor switch protein FliN [ND (AI144)] [Aeromonas hydrophila subsp. hydrophila ATCC 7966]
1846 gene978 VFG038656(gi:145298353) (fliM) flagellar motor switch protein FliM [Polar flagella (CVF786)] [Aeromonas salmonicida subsp. salmonicida A449]
852 gene979 VFG038650(gb|YP_855910) (fliL) flagellar basal body-associated protein FliL [ND (AI144)] [Aeromonas hydrophila subsp. hydrophila ATCC 7966]
705 gene981 VFG038642(gb|YP_855908) (fliJ) flagellar export protein FliJ [ND (AI144)] [Aeromonas hydrophila subsp. hydrophila ATCC 7966]
2258 gene982 VFG038640(gi:145298349) (fliI) flagellum-specific ATP synthase [Polar flagella (CVF786)] [Aeromonas salmonicida subsp. salmonicida A449]
1148 gene983 VFG038636(gi:145298348) (fliH) polar flagellar assembly protein, FliH [Polar flagella (CVF786)] [Aeromonas salmonicida subsp. salmonicida A449]
1813 gene984 VFG038633(gi:330828800) (fliG) flagellar motor switch protein FliG [Polar flagella (CVF786)] [Aeromonas veronii B565]
2746 gene985 VFG038627(gi:507520997) (fliF) flagellar MS-ring protein [Polar flagella (VF0473)] [Aeromonas hydrophila ML09-119]
529 gene986 VFG038624(gi:145298345) (fliE) flagellar hook-basal body protein [Polar flagella (CVF786)] [Aeromonas salmonicida subsp. salmonicida A449]
10801 gene998 VFG038912(gb|YP_855898) (rtxA) multifunctional autoprocessing repeats-in-toxins (MARTX) toxin [The repeat in toxin (RTX) (CVF795)] [Aeromonas hydrophila subsp. hydrophila ATCC 7966]
8593 gene998 VFG038912(gb|YP_855898) (rtxA) multifunctional autoprocessing repeats-in-toxins (MARTX) toxin [The repeat in toxin (RTX) (CVF795)] [Aeromonas hydrophila subsp. hydrophila ATCC 7966]
672 gene999 VFG038914(gb|YP_855897) (rtxC) cytolysin-activating lysine-acyltransferase RtxC [The repeat in toxin (RTX) (CVF795)] [Aeromonas hydrophila subsp. hydrophila ATCC 7966]
479 gene1000 VFG038915(gb|YP_855896) (rtxH) conserved hypothetical protein in rtx gene loci [The repeat in toxin (RTX) (CVF795)] [Aeromonas hydrophila subsp. hydrophila ATCC 7966]
3103 gene1001 VFG038916(gb|YP_855895) (rtxB) RTX toxin transporter, ATPase protein [The repeat in toxin (RTX) (CVF795)] [Aeromonas hydrophila subsp. hydrophila ATCC 7966]
2088 gene1002 VFG038917(gb|YP_855894) (rtxD) RTX toxin transporter, transmembrane protein linking with the outer membrane porin TolC [The repeat in toxin (RTX) (CVF795)] [Aeromonas hydrophila subsp. hydrophila ATCC 7966]
3043 gene1003 VFG038918(gb|YP_855893) (rtxE) RTX toxin transporter, ATPase protein [The repeat in toxin (RTX) (CVF795)] [Aeromonas hydrophila subsp. hydrophila ATCC 7966]
903 gene1042 VFG038370(gi:507521520) (hcp) HcpA-like protein [T6SS (VF0480)] [Aeromonas hydrophila ML09-119]
380 gene1043 VFG038405(gi:117619593) (AHA_1847) PAAR motif-containing protein [T6SS (SS194)] [Aeromonas hydrophila subsp. hydrophila ATCC 7966]
3109 gene1044 VFG038407(gb|YP_856382) (vgrG) VgrG protein [T6SS (SS194)] [Aeromonas hydrophila subsp. hydrophila ATCC 7966]
1573 gene1051 VFG038377(gi:145297534) (ASA_0454) lipoprotein [T6SS (CVF782)] [Aeromonas salmonicida subsp. salmonicida A449]
4329 gene1290 VFG038367(gb|YP_855660) (vgrG1) Type VI secretion system effector VgrG1, ADP-ribosyltransferase  [VgrG1 (TX001)] [Aeromonas hydrophila subsp. hydrophila ATCC 7966]
365 gene1291 VFG038405(gi:117619593) (AHA_1847) PAAR motif-containing protein [T6SS (SS194)] [Aeromonas hydrophila subsp. hydrophila ATCC 7966]
922 gene1292 VFG038370(gi:507521520) (hcp) HcpA-like protein [T6SS (VF0480)] [Aeromonas hydrophila ML09-119]
3430 gene1422 VFG044242(gi:145300215) (hutA) outer-membrane heme receptor [direct heme uptake system (IA062)] [Aeromonas salmonicida subsp. salmonicida A449]
1483 gene1423 VFG044243(gi:145300216) (ASA_3329) iron-regulated protein [direct heme uptake system (IA062)] [Aeromonas salmonicida subsp. salmonicida A449]
898 gene1424 VFG044244(gi:145300217) (ASA_3330) isochorismatase family protein [direct heme uptake system (IA062)] [Aeromonas salmonicida subsp. salmonicida A449]
650 gene1425 VFG044245(gi:145300218) (ASA_3331) hypothetical protein [direct heme uptake system (IA062)] [Aeromonas salmonicida subsp. salmonicida A449]
955 gene1426 VFG044246(gi:145300219) (hutZ) heme iron utilization protein [direct heme uptake system (IA062)] [Aeromonas salmonicida subsp. salmonicida A449]
870 gene1427 VFG044247(gi:145300220) (hutX) heme iron utilization protein [direct heme uptake system (IA062)] [Aeromonas salmonicida subsp. salmonicida A449]
1378 gene1428 VFG044248(gi:145300221) (hutB) ABC-type hemin transporter, periplasmic component [direct heme uptake system (IA062)] [Aeromonas salmonicida subsp. salmonicida A449]
1620 gene1429 VFG044249(gi:145300222) (hutC) ABC-type hemin transporter, permease protein [direct heme uptake system (IA062)] [Aeromonas salmonicida subsp. salmonicida A449]
1319 gene1430 VFG044250(gi:145300223) (hutD) ABC-type hemin transporter, ATP-binding protein [direct heme uptake system (IA062)] [Aeromonas salmonicida subsp. salmonicida A449]
1267 gene1588 VFG038837(gi:145298031) (pomA2) flagellar motor protein PomA [Polar flagella (CVF786)] [Aeromonas salmonicida subsp. salmonicida A449]
1442 gene1589 VFG038831(gb|YP_857806) (pomB2) flagellar motor protein MotB [Polar flagella (CVF786)] [Aeromonas hydrophila subsp. hydrophila ATCC 7966]
1601 gene1596 VFG013517(gi:113460873) (mrsA/glmM) phosphoglucosamine mutase [Exopolysaccharide (CVF495)] [Haemophilus somnus 129PT]
1065 gene1678 VFG038908(gb|YP_857708) (AHA_3217) thermostable hemolysin [Thermostable hemolysin (TH) (CVF794)] [Aeromonas hydrophila subsp. hydrophila ATCC 7966]
1752 gene1699 VFG038444(gi:507522925) (tapM) type IV pilus assembly protein [Tap type IV pili (VF0475)] [Aeromonas hydrophila ML09-119]
907 gene1700 VFG038447(gb|YP_857684) (tapN) type IV pilus biogenesis protein PilN [Tap type IV pili (CVF783)] [Aeromonas hydrophila subsp. hydrophila ATCC 7966]
998 gene1701 VFG038451(gb|YP_857683) (tapO) type IV pilus biogenesis protein PilO [Tap type IV pili (CVF783)] [Aeromonas hydrophila subsp. hydrophila ATCC 7966]
876 gene1702 VFG038457(gi:145298151) (tapP) type IV pilus biogenesis protein TapP [Tap pili (AI103)] [Aeromonas salmonicida subsp. salmonicida A449]
3617 gene1703 VFG038459(gb|YP_857681) (tapQ) type IV pilus secretin PilQ [Tap type IV pili (CVF783)] [Aeromonas hydrophila subsp. hydrophila ATCC 7966]
1219 gene1744 VFG013465(gb|NP_439706) (kdsA) 2-dehydro-3-deoxyphosphooctonate aldolase [LOS (CVF494)] [Haemophilus influenzae Rd KW20]
1443 gene1986 VFG007659(gi:59710773) (rmlB) dTDP-glucose 4,6-dehydratase [Capsular polysaccharide (CVF282)] [Vibrio fischeri ES114]
1104 gene1988 VFG005898(gi:125718225) (rmlA) Glucose-1-phosphate thymidylytransferase, putative [Capsule (CVF186)] [Streptococcus sanguinis SK36]
661 gene2027 VFG038829(gi:145298483) (flgN) flagellar biosynthetic protein FlgN [Polar flagella (CVF786)] [Aeromonas salmonicida subsp. salmonicida A449]
528 gene2028 VFG038823(gb|YP_857350) (flgM) anti-sigma-D factor [ND (AI144)] [Aeromonas hydrophila subsp. hydrophila ATCC 7966]
1108 gene2029 VFG038819(gb|YP_857349) (flgA) flagella basal body P-ring formation protein FlgA [ND (AI144)] [Aeromonas hydrophila subsp. hydrophila ATCC 7966]
1588 gene2030 VFG038815(gb|YP_857348) (cheV) CheV [ND (AI144)] [Aeromonas hydrophila subsp. hydrophila ATCC 7966]
1440 gene2031 VFG038811(gb|YP_857347) (cheR-3) chemotaxis protein CheR [ND (AI144)] [Aeromonas hydrophila subsp. hydrophila ATCC 7966]
674 gene2032 VFG038807(gb|YP_857346) (flgB) flagellar basal-body rod protein FlgB [ND (AI144)] [Aeromonas hydrophila subsp. hydrophila ATCC 7966]
710 gene2033 VFG038806(gi:330830305) (flgC) flagellar basal-body rod protein FlgC [Polar flagella (CVF786)] [Aeromonas veronii B565]
897 gene2034 VFG038802(gi:330830304) (flgD) flagellar hook capping protein [Polar flagella (CVF786)] [Aeromonas veronii B565]
1868 gene2035 VFG038798(gi:330830303) (flgE) flagellar hook protein FlgE [Polar flagella (CVF786)] [Aeromonas veronii B565]
1285 gene2036 VFG038793(gi:145298492) (flgF) flagellar basal body rod protein FlgF [Polar flagella (CVF786)] [Aeromonas salmonicida subsp. salmonicida A449]
1338 gene2037 VFG038790(gi:330830301) (flgG) flagellar basal body rod protein FlgG [Polar flagella (CVF786)] [Aeromonas veronii B565]
1134 gene2038 VFG038785(gi:145298494) (flgH) flagellar basal body L-ring protein [Polar flagella (CVF786)] [Aeromonas salmonicida subsp. salmonicida A449]
1852 gene2039 VFG038779(gb|YP_857339) (flgI) flagellar basal body P-ring protein [ND (AI144)] [Aeromonas hydrophila subsp. hydrophila ATCC 7966]
1718 gene2040 VFG038776(gi:507522554) (flgJ) flagellar rod assembly protein/muramidase FlgJ [Polar flagella (VF0473)] [Aeromonas hydrophila ML09-119]
3073 gene2041 VFG038773(gi:145298497) (flgK) flagellar hook-associated protein FlgK [Polar flagella (CVF786)] [Aeromonas salmonicida subsp. salmonicida A449]
1993 gene2042 VFG038767(gb|YP_857336) (flgL) flagellar hook-associated protein FlgL [ND (AI144)] [Aeromonas hydrophila subsp. hydrophila ATCC 7966]
2335 gene2048 VFG038763(gb|YP_857330) (fleQ/flrC) FleQ protein [ND (AI144)] [Aeromonas hydrophila subsp. hydrophila ATCC 7966]
1747 gene2049 VFG038761(gi:145298503) (flrB) two-component system flagellar sensor histidine kinase FlrB [Polar flagella (CVF786)] [Aeromonas salmonicida subsp. salmonicida A449]
2301 gene2050 VFG038755(gb|YP_857328) (fleR/flrC) transcriptional activator [ND (AI144)] [Aeromonas hydrophila subsp. hydrophila ATCC 7966]
2278 gene2067 VFG038902(gi:145298519) (hlyA) hemolysin [Hemolysin HlyA (CVF792)] [Aeromonas salmonicida subsp. salmonicida A449]
1271 gene2101 VFG038845(gi:507522470) (nueA) flagellar-related 3-deoxy-D-manno-octulosonate cytidylyltransferase [Polar flagella (VF0473)] [Aeromonas hydrophila ML09-119]
1937 gene2158 VFG038471(gb|YP_857247) (tapW) twitching ATPase [Tap type IV pili (CVF783)] [Aeromonas hydrophila subsp. hydrophila ATCC 7966]
713 gene2258 VFG018241(gb|NP_230208) (luxS) S-ribosylhomocysteinase [AI-2 (VF0406)] [Vibrio cholerae O1 biovar El Tor str. N16961]
562 gene2267 VFG038476(gi:507520227) (tppA) type IV pilus related protein [Tap type IV pili (VF0475)] [Aeromonas hydrophila ML09-119]
5719 gene2268 VFG038488(gi:507520226) (tapY) type IV pilus biogenesis protein [Tap type IV pili (VF0475)] [Aeromonas hydrophila ML09-119]
631 gene2271 VFG038480(gi:507520223) (tppB) type IV pilus modification protein [Tap type IV pili (VF0475)] [Aeromonas hydrophila ML09-119]
791 gene2272 VFG038493(gi:507520222) (tppE) type IV pilus related protein [Tap type IV pili (VF0475)] [Aeromonas hydrophila ML09-119]
1009 gene2299 VFG038619(gi:507520195) (motX) sodium-type flagellar motor component [Polar flagella (VF0473)] [Aeromonas hydrophila ML09-119]
1237 gene2397 VFG038314(gi:145300653) (exeN) general secretion pathway protein N [T2SS (CVF780)] [Aeromonas salmonicida subsp. salmonicida A449]
805 gene2398 VFG038310(gi:145300652) (exeM) general secretion pathway protein M [T2SS (CVF780)] [Aeromonas salmonicida subsp. salmonicida A449]
1906 gene2399 VFG038306(gi:145300651) (exeL) general secretion pathway protein L [T2SS (CVF780)] [Aeromonas salmonicida subsp. salmonicida A449]
1556 gene2400 VFG038302(gi:145300650) (exeK) general secretion pathway protein K [T2SS (CVF780)] [Aeromonas salmonicida subsp. salmonicida A449]
1050 gene2401 VFG038298(gi:145300649) (exeJ) general secretion pathway protein J [T2SS (CVF780)] [Aeromonas salmonicida subsp. salmonicida A449]
599 gene2402 VFG038293(gi:507520106) (exeI) general secretion pathway protein I [Exe T2SS (VF0478)] [Aeromonas hydrophila ML09-119]
870 gene2403 VFG038290(gi:145300647) (exeH) general secretion pathway protein H [T2SS (CVF780)] [Aeromonas salmonicida subsp. salmonicida A449]
744 gene2404 VFG038284(gb|YP_855105) (exeG) general secretion pathway protein G [exe (SS209)] [Aeromonas hydrophila subsp. hydrophila ATCC 7966]
2011 gene2405 VFG038282(gi:145300645) (exeF) general secretion pathway protein F [T2SS (CVF780)] [Aeromonas salmonicida subsp. salmonicida A449]
2541 gene2406 VFG038278(gi:145300644) (exeE) general secretion pathway protein E [T2SS (CVF780)] [Aeromonas salmonicida subsp. salmonicida A449]
3404 gene2407 VFG038274(gi:145300643) (exeD) general secretion pathway protein D [T2SS (CVF780)] [Aeromonas salmonicida subsp. salmonicida A449]
1365 gene2408 VFG038270(gi:145300642) (exeC) general secretion pathway protein C [T2SS (CVF780)] [Aeromonas salmonicida subsp. salmonicida A449]
866 gene2455 VFG038426(gi:145300598) (fimF) type I pilus assembly protein FimF [Type I fimbriae (CVF796)] [Aeromonas salmonicida subsp. salmonicida A449]
1293 gene2456 VFG038423(gi:330828179) (fimE) type I pilus assembly protein FimE [Type I fimbriae (CVF796)] [Aeromonas veronii B565]
1221 gene2457 VFG038417(gi:507520054) (fimD) fimbrial chaperone protein [Type I pili (VF0486)] [Aeromonas hydrophila ML09-119]
4249 gene2458 VFG038412(gb|YP_855054) (fimC) outer membrane usher protein [Type I fimbriae (CVF796)] [Aeromonas hydrophila subsp. hydrophila ATCC 7966]
499 gene2460 VFG038409(gi:507520051) (fimA) fimbrial protein [Type I pili (VF0486)] [Aeromonas hydrophila ML09-119]
2581 gene2545 VFG038891(gb|YP_854967) (aerA/act) Aerolysin A [aerolysin (TX450)] [Aeromonas hydrophila subsp. hydrophila ATCC 7966]
5402 gene2581 VFG038561(gi:507519914) (mshQ) MshQ protein [MSHA type IV pili (VF0477)] [Aeromonas hydrophila ML09-119]
659 gene2582 VFG038566(gi:330831355) (mshP) MSHA biogenesis protein MshP [Mannose-sensitive hemagglutinin (Msh) pilus, type IV pili (CVF785)] [Aeromonas veronii B565]
1200 gene2583 VFG038568(gi:507519912) (mshO) MSHA biogenesis protein mshO [MSHA type IV pili (VF0477)] [Aeromonas hydrophila ML09-119]
853 gene2584 VFG038574(gi:330831357) (mshD) MSHA biogenesis protein MshN/MshD [Mannose-sensitive hemagglutinin (Msh) pilus, type IV pili (CVF785)] [Aeromonas veronii B565]
629 gene2585 VFG038576(gi:507519910) (mshC) MSHA pilin protein mshC [MSHA type IV pili (VF0477)] [Aeromonas hydrophila ML09-119]
1097 gene2587 VFG038580(gb|YP_854924) (mshB) MSHA (mannose-sensitive hemagglutinin) pili minor prepilin protein MshB [Mannose-sensitive hemagglutinin (Msh) pilus, type IV pili (CVF785)] [Aeromonas hydrophila subsp. hydrophila ATCC 7966]
537 gene2588 VFG038584(gi:507519907) (mshF) hypothetical protein [MSHA type IV pili (VF0477)] [Aeromonas hydrophila ML09-119]
2050 gene2589 VFG038586(gb|YP_854922) (mshG) MSHA (mannose-sensitive hemagglutinin) pili biogenesis protein MshG, GspF-like [Mannose-sensitive hemagglutinin (Msh) pilus, type IV pili (CVF785)] [Aeromonas hydrophila subsp. hydrophila ATCC 7966]
2920 gene2590 VFG038589(gb|YP_854921) (mshE) ATPase protein MshE, GspE-like [Mannose-sensitive hemagglutinin (Msh) pilus, type IV pili (CVF785)] [Aeromonas hydrophila subsp. hydrophila ATCC 7966]
1359 gene2591 VFG038593(gi:507519904) (mshN) hypothetical protein [MSHA type IV pili (VF0477)] [Aeromonas hydrophila ML09-119]
1373 gene2592 VFG038596(gi:507519903) (mshM) general secretion pathway protein A [MSHA type IV pili (VF0477)] [Aeromonas hydrophila ML09-119]
2472 gene2593 VFG038601(gi:145300802) (mshL) MSHA biogenesis protein MshL [Mannose-sensitive hemagglutinin (Msh) pilus, type IV pili (CVF785)] [Aeromonas salmonicida subsp. salmonicida A449]
497 gene2594 VFG038604(gi:145300803) (mshK) MSHA biogenesis protein MshK [Mannose-sensitive hemagglutinin (Msh) pilus, type IV pili (CVF785)] [Aeromonas salmonicida subsp. salmonicida A449]
1029 gene2595 VFG038608(gi:145300804) (mshJ) MSHA biogenesis protein MshJ [Mannose-sensitive hemagglutinin (Msh) pilus, type IV pili (CVF785)] [Aeromonas salmonicida subsp. salmonicida A449]
958 gene2596 VFG038612(gi:145300805) (mshI1) MSHA biogenesis protein MshI1 [Mannose-sensitive hemagglutinin (Msh) pilus, type IV pili (CVF785)] [Aeromonas salmonicida subsp. salmonicida A449]
1441 gene2597 VFG038616(gi:145300806) (mshI) MSHA biogenesis protein MshI [Mannose-sensitive hemagglutinin (Msh) pilus, type IV pili (CVF785)] [Aeromonas salmonicida subsp. salmonicida A449]
1286 gene2715 VFG038317(gi:507523595) (tapD) prepilin peptidase [Exe T2SS (VF0478)] [Aeromonas hydrophila ML09-119]
2150 gene2716 VFG038435(gb|YP_858309) (tapC) type IV fimbrial assembly protein, PilC-like [Tap type IV pili (CVF783)] [Aeromonas hydrophila subsp. hydrophila ATCC 7966]
2983 gene2717 VFG038432(gi:507523593) (tapB) type IV pilus assembly ATPase [Tap type IV pili (VF0475)] [Aeromonas hydrophila ML09-119]
984 gene2802 VFG038266(gi:145297588) (exeB) general secretion pathway protein B [T2SS (CVF780)] [Aeromonas salmonicida subsp. salmonicida A449]
2809 gene2803 VFG038262(gi:145297589) (exeA) general secretion pathway protein A [T2SS (CVF780)] [Aeromonas salmonicida subsp. salmonicida A449]
244 gene2876 VFG010907(gi:54296805) (csrA) global regulator CsrA [Carbon storage regulator A (CVF362)] [Legionella pneumophila str. Paris]
969 gene2889 VFG038496(gb|YP_858148) (tppF) type IV pilus pseudopilin [Tap type IV pili (CVF783)] [Aeromonas hydrophila subsp. hydrophila ATCC 7966]
3895 gene2900 VFG042801(gi:145300516) (tapZ) type IV pilus assembly TapZ [Tap pili (AI103)] [Aeromonas salmonicida subsp. salmonicida A449]
1843 gene2935 VFG038468(gi:507523358) (tapU) type IV pilus twitching motility protein [Tap type IV pili (VF0475)] [Aeromonas hydrophila ML09-119]
1813 gene2936 VFG038465(gi:145300500) (tapT) type IV pilus protein TapT [Tap pili (AI103)] [Aeromonas salmonicida subsp. salmonicida A449]
1473 gene3069 VFG038368(gi:507520712) (vgrG1) Rhs element Vgr protein [T6SS (VF0480)] [Aeromonas hydrophila ML09-119]
922 gene3070 VFG038370(gi:507521520) (hcp) HcpA-like protein [T6SS (VF0480)] [Aeromonas hydrophila ML09-119]
1513 gene3224 VFG038752(gb|YP_857151) (motY) sodium-type flagellar protein MotY [Polar flagella (CVF786)] [Aeromonas hydrophila subsp. hydrophila ATCC 7966]
2744 gene3263 VFG038502(gi:145299468) (tapV) type IV pilus assembly protein TapV [Tap pili (AI103)] [Aeromonas salmonicida subsp. salmonicida A449]
782 gene3283 VFG038407(gb|YP_856382) (vgrG) VgrG protein [T6SS (SS194)] [Aeromonas hydrophila subsp. hydrophila ATCC 7966]
181 gene3471 VFG046465(gb|YP_169203.1) (tufA) elongation factor Tu [EF-Tu (VF0460)] [Francisella tularensis subsp. tularensis SCHU S4]
3492 gene3501 VFG049190 (KOX_00005) protein disaggregation chaperone [T6SS-II (CVF861)] [Klebsiella oxytoca KCTC 1686]
1238 gene3600 VFG038841(gi:145297258) (flmH) 3-oxoacyl-ACP reductase [Polar flagella (CVF786)] [Aeromonas salmonicida subsp. salmonicida A449]
867 gene3602 VFG038843(gi:145297256) (flmH) flagellar modification protein FlmH [Polar flagella (CVF786)] [Aeromonas salmonicida subsp. salmonicida A449]
1171 gene3603 VFG038846(gi:145297255) (nueA) CMP-N-acetylneuraminic acid synthetase [Polar flagella (CVF786)] [Aeromonas salmonicida subsp. salmonicida A449]
1736 gene3604 VFG038847(gb|YP_858602) (flmD) FlmD protein [Polar flagella (CVF786)] [Aeromonas hydrophila subsp. hydrophila ATCC 7966]
1806 gene3605 VFG038852(gi:145297253) (nueB) sialic acid synthase [Polar flagella (CVF786)] [Aeromonas salmonicida subsp. salmonicida A449]
2032 gene3606 VFG038853(gb|YP_858604) (maf-2) Maf-2 [Polar flagella (CVF786)] [Aeromonas hydrophila subsp. hydrophila ATCC 7966]
2023 gene3796 VFG045692(gi:289163963) (htpB) molecular chaperone GroEL [Hsp60 (CVF347)] [Legionella longbeachae NSW150]
1247 gene3826 VFG000477(gi:16766230) (rpoS) sigma S (sigma 38) factor of RNA polymerase, major sigmafactor during stationary phase [RpoS (VF0112)] [Salmonella enterica subsp. enterica serovar Typhimurium str. LT2]
2852 gene3852 VFG038896(gi:507520337) (ast) enterotoxin [Heat-stable cytotonic enterotoxin, Ast (CVF789)] [Aeromonas hydrophila ML09-119]
1508 gene3878 VFG013612(gi:113461676) (hemE) uroporphyrinogen decarboxylase [Heme biosynthesis (CVF506)] [Haemophilus somnus 129PT]
1378 gene4205 VFG013197(gi:170717931) (hemB) Porphobilinogen synthase [Heme biosynthesis (CVF506)] [Haemophilus somnus 2336]
2241 gene4259 VFG013531(gi:68249838) (pgi) glucose-6-phosphate isomerase [Exopolysaccharide (CVF495)] [Haemophilus influenzae 86-028NP]
835 gene4294 VFG038407(gb|YP_856382) (vgrG) VgrG protein [T6SS (SS194)] [Aeromonas hydrophila subsp. hydrophila ATCC 7966]
455 gene4295 VFG038405(gi:117619593) (AHA_1847) PAAR motif-containing protein [T6SS (SS194)] [Aeromonas hydrophila subsp. hydrophila ATCC 7966]
2398 gene4296 VFG038403(gb|YP_856380) (AHA_1846) Type VI secretion system protein [T6SS (SS194)] [Aeromonas hydrophila subsp. hydrophila ATCC 7966]
5844 gene4297 VFG038402(gb|YP_856379) (vasK/icmF) Type VI secretion system protein [T6SS (SS194)] [Aeromonas hydrophila subsp. hydrophila ATCC 7966]
2030 gene4298 VFG038401(gb|YP_856378) (AHA_1844) Type VI secretion system protein [T6SS (SS194)] [Aeromonas hydrophila subsp. hydrophila ATCC 7966]
866 gene4299 VFG038400(gi:145299405) (ASA_2459) hypothetical protein [T6SS (CVF782)] [Aeromonas salmonicida subsp. salmonicida A449]
2633 gene4300 VFG038398(gi:145299406) (vasH) type VI secretion system sigma-54 dependent transcriptional regulator [T6SS (CVF782)] [Aeromonas salmonicida subsp. salmonicida A449]
4403 gene4301 VFG038396(gi:145299407) (clpB) type VI secretion system clpB chaperone [T6SS (CVF782)] [Aeromonas salmonicida subsp. salmonicida A449]
1338 gene4302 VFG038394(gi:145299408) (ASA_2462) hypothetical protein [T6SS (CVF782)] [Aeromonas salmonicida subsp. salmonicida A449]
2306 gene4303 VFG038392(gi:145299409) (ASA_2463) hypothetical protein [T6SS (CVF782)] [Aeromonas salmonicida subsp. salmonicida A449]
858 gene4304 VFG038390(gi:145299410) (ASA_2464) hypothetical protein [T6SS (CVF782)] [Aeromonas salmonicida subsp. salmonicida A449]
1985 gene4305 VFG038388(gi:145299411) (ASA_2465) hypothetical protein [T6SS (CVF782)] [Aeromonas salmonicida subsp. salmonicida A449]
1705 gene4306 VFG038386(gi:145299412) (ASA_2466) hypothetical protein [T6SS (CVF782)] [Aeromonas salmonicida subsp. salmonicida A449]
3092 gene4307 VFG038383(gb|YP_856369) (AHA_1835) Type VI secretion system protein [T6SS (SS194)] [Aeromonas hydrophila subsp. hydrophila ATCC 7966]
738 gene4308 VFG038381(gb|YP_856368) (AHA_1834) Type VI secretion system protein [T6SS (SS194)] [Aeromonas hydrophila subsp. hydrophila ATCC 7966]
2587 gene4309 VFG038380(gb|YP_856367) (AHA_1833) Type VI secretion system contractile sheath large subunit TssC/VipB [T6SS (SS194)] [Aeromonas hydrophila subsp. hydrophila ATCC 7966]
818 gene4310 VFG038379(gi:145299415) (ASA_2470) hypothetical protein [T6SS (CVF782)] [Aeromonas salmonicida subsp. salmonicida A449]
1933 gene4311 VFG038376(gb|YP_856365) (AHA_1831) Type VI secretion system protein [T6SS (SS194)] [Aeromonas hydrophila subsp. hydrophila ATCC 7966]
810 gene4312 VFG038375(gb|YP_856364) (AHA_1830) Type VI secretion system protein [T6SS (SS194)] [Aeromonas hydrophila subsp. hydrophila ATCC 7966]
1622 gene4313 VFG038374(gb|YP_856363) (AHA_1829) Type VI secretion system protein [T6SS (SS194)] [Aeromonas hydrophila subsp. hydrophila ATCC 7966]
2157 gene4314 VFG038373(gb|YP_856362) (AHA_1828) Type VI secretion system protein [T6SS (SS194)] [Aeromonas hydrophila subsp. hydrophila ATCC 7966]
1117 gene4315 VFG038371(gb|YP_856361) (vgrG) VgrG protein [T6SS (SS194)] [Aeromonas hydrophila subsp. hydrophila ATCC 7966]
1032 gene4318 VFG038905(gi:507523204) (AHML_18530) hemolysin [Hemolysin III (CVF793)] [Aeromonas hydrophila ML09-119]
181 gene4337 VFG046465(gb|YP_169203.1) (tufA) elongation factor Tu [EF-Tu (VF0460)] [Francisella tularensis subsp. tularensis SCHU S4]
143 gene4354 VFG046475 (F7308_0636) translation elongation factor Tu [EF-Tu (CVF827)] [Francisella sp. TX077308]
1509 gene4357 VFG046474 (OOM_0626) elongation factor [EF-Tu (CVF827)] [Francisella noatunensis subsp. orientalis str. Toba 04]
1389 gene4361 VFG038368(gi:507520712) (vgrG1) Rhs element Vgr protein [T6SS (VF0480)] [Aeromonas hydrophila ML09-119]

Table S10. Genome annotation by CARD(A01)

Gene ID

ARO Accession

ARO Name

gene120

ARO:3003553

CepS

gene226

ARO:3003899

Escherichia coli PtsI with mutation conferring resistance to fosfomycin

gene472

ARO:3003893

Escherichia coli UhpA with mutation conferring resistance to fosfomycin

gene910

ARO:3003099

cphA2

gene1010

ARO:3003890

Escherichia coli UhpT with mutation conferring resistance to fosfomycin

gene1250

ARO:3005069

rsmA

gene1291

ARO:3003317

Salmonella serovars parE conferring resistance to fluoroquinolones

gene1514

ARO:3003889

Escherichia coli GlpT with mutation conferring resistance to fosfomycin

gene2006

ARO:3000518

CRP

gene2015

ARO:3002985

arnA

gene2139

ARO:3004693

MCR-3.12

gene2610

ARO:3003368

Escherichia coli EF-Tu mutants conferring resistance to kirromycin

gene2772

ARO:3003930

rpsJ

gene2983

ARO:3003926

Salmonella enterica gyrA conferring resistance to fluoroquinolones

gene3584

ARO:3004837

OXA-724

gene3616

ARO:3003307

Salmonella serovars gyrB conferring resistance to fluoroquinolones

gene4032

ARO:3004049

Escherichia coli fabG mutations conferring resistance to triclosan

gene4425

ARO:3003368

Escherichia coli EF-Tu mutants conferring resistance to kirromycin

gene4428

ARO:3003395

Mycobacterium tuberculosis rpsL mutations conferring resistance to Streptomycin

gene4435

ARO:3003288

Escherichia coli rpoB mutants conferring resistance to rifampicin

gene4524

ARO:3003368

Escherichia coli EF-Tu mutants conferring resistance to kirromycin

Table S11. Genome annotation by CARD(A03)

Gene ID

ARO Accession

ARO Name

gene394

ARO:3003890

Escherichia coli UhpT with mutation conferring resistance to fosfomycin

gene622

ARO:3003889

Escherichia coli GlpT with mutation conferring resistance to fosfomycin

gene680

ARO:3003893

Escherichia coli UhpA with mutation conferring resistance to fosfomycin

gene792

ARO:3004517

MCR-7.1

gene912

ARO:3003577

ugd

gene1027

ARO:3003899

Escherichia coli PtsI with mutation conferring resistance to fosfomycin

gene1270

ARO:3000518

CRP

gene1663

ARO:3005069

rsmA

gene1740

ARO:3003317

Salmonella serovars parE conferring resistance to fluoroquinolones

gene2005

ARO:3003368

Escherichia coli EF-Tu mutants conferring resistance to kirromycin

gene2008

ARO:3003395

Mycobacterium tuberculosis rpsL mutations conferring resistance to Streptomycin

gene2015

ARO:3003288

Escherichia coli rpoB mutants conferring resistance to rifampicin

gene2022

ARO:3003368

Escherichia coli EF-Tu mutants conferring resistance to kirromycin

gene2449

ARO:3002986

bacA

gene2504

ARO:3003103

cphA7

gene2747

ARO:3004049

Escherichia coli fabG mutations conferring resistance to triclosan

gene2780

ARO:3002156

FOX-2

gene3091

ARO:3005041

mlaF

gene3205

ARO:3003303

Escherichia coli gyrB conferring resistance to aminocoumarin

gene3287

ARO:3003926

Salmonella enterica gyrA conferring resistance to fluoroquinolones

gene3502

ARO:3001407

OXA-12

gene3804

ARO:3003930

rpsJ

gene4137

ARO:3000173

tet(E)

Table S12. Genome annotation by CARD(A04)

Gene ID

ARO Accession

ARO Name

gene120

ARO:3003553

CepS

gene226

ARO:3003899

Escherichia coli PtsI with mutation conferring resistance to fosfomycin

gene471

ARO:3003893

Escherichia coli UhpA with mutation conferring resistance to fosfomycin

gene908

ARO:3003099

cphA2

gene1010

ARO:3003890

Escherichia coli UhpT with mutation conferring resistance to fosfomycin

gene1242

ARO:3003889

Escherichia coli GlpT with mutation conferring resistance to fosfomycin

gene1610

ARO:3000518

CRP

gene1619

ARO:3002985

arnA

gene2108

ARO:3004693

MCR-3.12

gene2485

ARO:3003368

Escherichia coli EF-Tu mutants conferring resistance to kirromycin

gene2492

ARO:3003288

Escherichia coli rpoB mutants conferring resistance to rifampicin

gene2499

ARO:3003395

Mycobacterium tuberculosis rpsL mutations conferring resistance to Streptomycin

gene2502

ARO:3003368

Escherichia coli EF-Tu mutants conferring resistance to kirromycin

gene2514

ARO:3005069

rsmA

gene2582

ARO:3003317

Salmonella serovars parE conferring resistance to fluoroquinolones

gene2875

ARO:3003926

Salmonella enterica gyrA conferring resistance to fluoroquinolones

gene3075

ARO:3003930

rpsJ

gene3666

ARO:3003307

Salmonella serovars gyrB conferring resistance to fluoroquinolones

gene3698

ARO:3004837

OXA-724

gene3965

ARO:3004049

Escherichia coli fabG mutations conferring resistance to triclosan

Table S13. Genome annotation by CARD(A12)

Gene ID

ARO Accession

ARO Name

gene358

ARO:3003890

Escherichia coli UhpT with mutation conferring resistance to fosfomycin

gene702

ARO:3000518

CRP

gene1141

ARO:3004517

MCR-7.1

gene1255

ARO:3003893

Escherichia coli UhpA with mutation conferring resistance to fosfomycin

gene1319

ARO:3003889

Escherichia coli GlpT with mutation conferring resistance to fosfomycin

gene1638

ARO:3005041

mlaF

gene1903

ARO:3003926

Salmonella enterica gyrA conferring resistance to fluoroquinolones

gene1993

ARO:3004049

Escherichia coli fabG mutations conferring resistance to triclosan

gene2523

ARO:3003317

Salmonella serovars parE conferring resistance to fluoroquinolones

gene2625

ARO:3003930

rpsJ

gene2707

ARO:3002986

bacA

gene2932

ARO:3005069

rsmA

gene3054

ARO:3003368

Escherichia coli EF-Tu mutants conferring resistance to kirromycin

gene3303

ARO:3003899

Escherichia coli PtsI with mutation conferring resistance to fosfomycin

gene3412

ARO:3001407

OXA-12

gene3445

ARO:3003303

Escherichia coli gyrB conferring resistance to aminocoumarin

gene3577

ARO:3003093

cphA3

gene3594

ARO:3002156

FOX-2

gene3945

ARO:3003368

Escherichia coli EF-Tu mutants conferring resistance to kirromycin

gene3948

ARO:3003395

Mycobacterium tuberculosis rpsL mutations conferring resistance to Streptomycin

gene3955

ARO:3003288

Escherichia coli rpoB mutants conferring resistance to rifampicin

gene3963

ARO:3003368

Escherichia coli EF-Tu mutants conferring resistance to kirromycin

Table S14. Genome annotation by CARD(A15)

Gene ID

ARO Accession

ARO Name

gene129

ARO:3003890

Escherichia coli UhpT with mutation conferring resistance to fosfomycin

gene768

ARO:3003899

Escherichia coli PtsI with mutation conferring resistance to fosfomycin

gene883

ARO:3003577

ugd

gene1515

ARO:3003889

Escherichia coli GlpT with mutation conferring resistance to fosfomycin

gene1572

ARO:3003893

Escherichia coli UhpA with mutation conferring resistance to fosfomycin

gene1685

ARO:3004517

MCR-7.1

gene1908

ARO:3000518

CRP

gene2237

ARO:3003926

Salmonella enterica gyrA conferring resistance to fluoroquinolones

gene2595

ARO:3005041

mlaF

gene2730

ARO:3003317

Salmonella serovars parE conferring resistance to fluoroquinolones

gene2821

ARO:3003930

rpsJ

gene2897

ARO:3002986

bacA

gene3074

ARO:3005069

rsmA

gene3146

ARO:3003303

Escherichia coli gyrB conferring resistance to aminocoumarin

gene3190

ARO:3001407

OXA-12

gene3279

ARO:3003093

cphA3

gene3679

ARO:3003368

Escherichia coli EF-Tu mutants conferring resistance to kirromycin

gene3894

ARO:3000173

tet(E)

gene3959

ARO:3003368

Escherichia coli EF-Tu mutants conferring resistance to kirromycin

gene3966

ARO:3003288

Escherichia coli rpoB mutants conferring resistance to rifampicin

gene3973

ARO:3003395

Mycobacterium tuberculosis rpsL mutations conferring resistance to Streptomycin

gene3976

ARO:3003368

Escherichia coli EF-Tu mutants conferring resistance to kirromycin

gene3984

ARO:3004049

Escherichia coli fabG mutations conferring resistance to triclosan

gene4005

ARO:3003368

Escherichia coli EF-Tu mutants conferring resistance to kirromycin

gene4007

ARO:3003368

Escherichia coli EF-Tu mutants conferring resistance to kirromycin

Table S15. Genome annotation by CARD(A16)

Gene ID

ARO Accession

ARO Name

gene182

ARO:3000775

adeB

gene703

ARO:3003317

Salmonella serovars parE conferring resistance to fluoroquinolones

gene838

ARO:3003899

Escherichia coli PtsI with mutation conferring resistance to fosfomycin

gene1000

ARO:3003893

Escherichia coli UhpA with mutation conferring resistance to fosfomycin

gene1116

ARO:3004517

MCR-7.1

gene1438

ARO:3003890

Escherichia coli UhpT with mutation conferring resistance to fosfomycin

gene2006

ARO:3005041

mlaF

gene2174

ARO:3002986

bacA

gene2250

ARO:3003930

rpsJ

gene2332

ARO:3003303

Escherichia coli gyrB conferring resistance to aminocoumarin

gene2396

ARO:3001407

OXA-12

gene2591

ARO:3003926

Salmonella enterica gyrA conferring resistance to fluoroquinolones

gene3074

ARO:3003368

Escherichia coli EF-Tu mutants conferring resistance to kirromycin

gene3081

ARO:3003288

Escherichia coli rpoB mutants conferring resistance to rifampicin

gene3088

ARO:3003395

Mycobacterium tuberculosis rpsL mutations conferring resistance to Streptomycin

gene3091

ARO:3003368

Escherichia coli EF-Tu mutants conferring resistance to kirromycin

gene3177

ARO:3004049

Escherichia coli fabG mutations conferring resistance to triclosan

gene3548

ARO:3003093

cphA3

gene3695

ARO:3000518

CRP

gene3754

ARO:3003889

Escherichia coli GlpT with mutation conferring resistance to fosfomycin

gene3833

ARO:3005069

rsmA

gene4034

ARO:3003368

Escherichia coli EF-Tu mutants conferring resistance to kirromycin

Table S16. Genome annotation by CARD(A17)

Gene ID

ARO Accession

ARO Name

gene50

ARO:3003926

Salmonella enterica gyrA conferring resistance to fluoroquinolones

gene129

ARO:3004049

Escherichia coli fabG mutations conferring resistance to triclosan

gene686

ARO:3003889

Escherichia coli GlpT with mutation conferring resistance to fosfomycin

gene928

ARO:3003890

Escherichia coli UhpT with mutation conferring resistance to fosfomycin

gene1402

ARO:3002985

arnA

gene1411

ARO:3000518

CRP

gene1755

ARO:3002156

FOX-2

gene1848

ARO:3003899

Escherichia coli PtsI with mutation conferring resistance to fosfomycin

gene2080

ARO:3003893

Escherichia coli UhpA with mutation conferring resistance to fosfomycin

gene2214

ARO:3003094

imiH

gene2657

ARO:3005041

mlaF

gene2833

ARO:3003317

Salmonella serovars parE conferring resistance to fluoroquinolones

gene2876

ARO:3005069

rsmA

gene3253

ARO:3004693

MCR-3.12

gene3471

ARO:3003368

Escherichia coli EF-Tu mutants conferring resistance to kirromycin

gene3690

ARO:3003930

rpsJ

gene3914

ARO:3003115

OXA-427

gene3946

ARO:3003303

Escherichia coli gyrB conferring resistance to aminocoumarin

gene4337

ARO:3003368

Escherichia coli EF-Tu mutants conferring resistance to kirromycin

gene4340

ARO:3003395

Mycobacterium tuberculosis rpsL mutations conferring resistance to Streptomycin

gene4347

ARO:3003288

Escherichia coli rpoB mutants conferring resistance to rifampicin

gene4354

ARO:3003368

Escherichia coli EF-Tu mutants conferring resistance to kirromycin

gene4357

ARO:3003368

Escherichia coli EF-Tu mutants conferring resistance to kirromycin
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