The objective of this paper is to study the mechanical behavior of the abdominal aortic aneurysm (AAA) created from the xenograft rat model. Based on uniaxial traction tests on arterial samples on the one hand, and histological analysis on the other, a finite element model is proposed. By considering the mechanical behavior of the AAA tissue as hyperelastic, isotropic and incompressible, the wall stresses are calculated. We show that the peak stress is localized where the thrombus created by the xenograft rat model is thinner.
abdominal aorta aneurysm, xenograft rat model, wall stresses, finite element
Ces travaux ont été soutenus par le Programme Hubert Curien Tassili no 15MDU934 dans le cadre d’un partenariat franco-algérien.
Allaire E., Muscatelli-Groux B., Guinault A.M., Pages C., Goussard A., Mandet C., Bruneval P., Becquemin J.P. (2004). Vascular smooth muscle cell endovascular therapy stabilizes already developed aneurysms in a model of aortic injury elicited by inflammation and proteolysis. Annals of Surgery, vol. 239, p. 417-427.
Anidjar S., Salzmann J.L., Gentric D., Lagneau P., Camilleri P., Michel J.B. (1990). Elastaseinduced experimental aneurysms in rats. Circulation, vol. 82, p. 973-981.
Dobrin P.B. (1989). Pathophysiology and pathogenesis of aortic aneurysms. Current concepts. Surgical Clinics of North America, vol. 69, p. 687-703.
Humphrey J.D., Taylor C.A. (2008). Intracranial and abdominal aortic aneurysms: similarities, differences, and need for a new class of computational models. Annual Review of Biomedical Engineering, vol. 10, p. 221-246.
Humphrey J.D., Holzapfel G.A. (2012). Mechanics, mechanobiology, and modeling of human abdominal aorta and aneurysms. Journal of Biomechanics, vol. 45, p. 805-814.
Humphrey J.D. (2009). Cardiovascular solid mechanics: cells, tissues, and organs. Springer-Verlag, New York.
Holzapfel G. (2000). Non linear solid mechanics. Wiley, Chichester, WestSussex, England. Marais L., Franck G., Allaire E., Zidi M. (2016). Diameter and thickness-related variations in mechanical properties of degraded arterial wall in the rat xenograft model. Journal of Biomechanics, vol. 49, no 14, p. 3467-3475.
Marais L., Zidi M. (2017). Mechanical behavior of the abdominal aortic aneurysm assessed by biaxial tests in the rat xenograft model. Journal of the Mechanical Behavior of Biomedical Materials, vol. 74, p. 28-34.
Michineau S., Dai J., Gervais M., Zidi M., Clowes A.W., Becquemin J.P., Michel J.B., Allaire E. (2009). Aortic length changes during abdominal aortic aneurysm formation, expansion and stabilization in a rat model. European Journal of Vascular and Endovascular Surgery, vol. 40, p. 468-474.
Mohand-Kaci F., Ouni A.E., Dai J., Allaire E., Zidi M. (2012). Stochastic modelling of wall stresses in abdominal aortic aneurysms treated by a gene therapy. Computer Methods in Biomechanics and Biomedical Engineering, vol. 15, p. 435-443
O’Connell M.K., Kimura H., Sho E., Sho M., Dalman R.L., Taylor C.A. (2003). Correlation of mechanical properties and microstructure of rat elastase-infusion abdominal aortic aneurysms. Summer Bioengineering Conference, Sonesta Beach Resort in Key Biscayne, Florida, p. 871-872.
Sakalihasan N., Limet R., Defawe O.D. (2005). Abdominal aortic aneurysm. Lancet, vol. 365, no 9470, p. 1577-1589.
Vorp V.A. (2007). Biomechanics of abdominal aortic aneurysm. Journal of Biomechanics, vol. 40, p. 1887-1902.
Zidi M., Allaire E. (2015). Mechanical behavior of abdominal aorta aneurysm in rat model treated by cell therapy using mesenchymal stem cells. Biomechanics and Modelling in Mechanobiology, vol. 14, no 1, p. 185-194.